Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1503595..1503966 Replicon chromosome
Accession NZ_CP053604
Organism Escherichia coli strain NEB10-beta

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag HO394_RS07370 Protein ID WP_001317028.1
Coordinates 1503772..1503966 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1503595..1503773 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO394_RS07345 1499550..1500923 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
HO394_RS07350 1501052..1501987 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
HO394_RS07355 1502039..1503274 - 1236 WP_000040852.1 site-specific integrase -
HO394_RS07360 1503276..1503491 - 216 WP_000079604.1 excisionase XisR -
HO394_RS07365 1503570..1503779 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1503595..1503773 + 179 NuclAT_0 - Antitoxin
- 1503595..1503773 + 179 NuclAT_0 - Antitoxin
- 1503595..1503773 + 179 NuclAT_0 - Antitoxin
- 1503595..1503773 + 179 NuclAT_0 - Antitoxin
HO394_RS07370 1503772..1503966 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
HO394_RS07375 1504023..1504832 - 810 WP_000166319.1 recombination protein RecT -
HO394_RS07380 1504825..1507425 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
HO394_RS07385 1507527..1507802 - 276 WP_000632297.1 protein RacC -
HO394_RS07390 1507877..1508047 - 171 WP_001352098.1 conserved protein, Rac prophage -
HO394_RS07395 1508047..1508268 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1502039..1523712 21673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T157096 WP_001317028.1 NZ_CP053604:c1503966-1503772 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T157096 NZ_CP069076:c1575042-1574641 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 179 bp

>AT157096 NZ_CP053604:1503595-1503773 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References