Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1397603..1397974 Replicon chromosome
Accession NZ_CP053603
Organism Escherichia coli strain Dam/Dcm

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag HO395_RS06785 Protein ID WP_001317028.1
Coordinates 1397780..1397974 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1397603..1397781 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO395_RS06760 1393558..1394931 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
HO395_RS06765 1395060..1395995 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
HO395_RS06770 1396047..1397282 - 1236 WP_000040852.1 site-specific integrase -
HO395_RS06775 1397284..1397499 - 216 WP_000079604.1 excisionase XisR -
HO395_RS06780 1397578..1397787 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1397603..1397781 + 179 NuclAT_0 - Antitoxin
- 1397603..1397781 + 179 NuclAT_0 - Antitoxin
- 1397603..1397781 + 179 NuclAT_0 - Antitoxin
- 1397603..1397781 + 179 NuclAT_0 - Antitoxin
HO395_RS06785 1397780..1397974 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
HO395_RS06790 1398031..1398840 - 810 WP_000166319.1 recombination protein RecT -
HO395_RS06795 1398833..1401433 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
HO395_RS06800 1401535..1401810 - 276 WP_000632297.1 protein RacC -
HO395_RS06805 1401885..1402055 - 171 WP_001352098.1 conserved protein, Rac prophage -
HO395_RS06810 1402055..1402276 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1396047..1417720 21673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T157059 WP_001317028.1 NZ_CP053603:c1397974-1397780 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T157059 NZ_CP069075:c3077967-3077551 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 179 bp

>AT157059 NZ_CP053603:1397603-1397781 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References