149484

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 34174..34428 Replicon plasmid putative_pEcol1
Accession NZ_CP048440
Organism Escherichia coli strain NBRC 3301

Toxin (Protein)


Gene name srnB Uniprot ID -
Locus tag GXM24_RS22670 Protein ID WP_001362723.1
Coordinates 34174..34380 (-) Length 69 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 34367..34428 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GXM24_RS22650 30283..30834 + 552 WP_001235704.1 recombinase family protein -
GXM24_RS22655 30850..32946 + 2097 WP_000422420.1 hypothetical protein -
GXM24_RS22660 33325..33399 - 75 WP_001442103.1 RepA leader peptide Tap -
GXM24_RS22665 33633..33890 - 258 WP_000083834.1 replication regulatory protein RepA -
GXM24_RS22670 34174..34380 - 207 WP_001362723.1 type I toxin-antitoxin system Hok family toxin Toxin
- 34367..34428 + 62 NuclAT_1 - Antitoxin
- 34367..34428 + 62 NuclAT_1 - Antitoxin
- 34367..34428 + 62 NuclAT_1 - Antitoxin
- 34367..34428 + 62 NuclAT_1 - Antitoxin
GXM24_RS22675 34724..35035 + 312 WP_000802277.1 hypothetical protein -
GXM24_RS23145 35216..35302 - 87 Protein_26 endonuclease -
GXM24_RS22680 35500..35688 - 189 WP_001345829.1 hypothetical protein -
GXM24_RS22685 35823..35990 - 168 Protein_28 conjugal transfer protein -
GXM24_RS22700 37252..37644 - 393 Protein_30 fertility inhibition protein FinO -
GXM24_RS22705 37699..38445 - 747 WP_000205776.1 conjugal transfer pilus acetylase TraX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Conjugative plasmid - - 1..98786 98786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(23-64)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7792.29 Da        Isoelectric Point: 8.8807

>T149484 WP_001362723.1 NZ_CP048440:c34380-34174 [Escherichia coli]
MKYLNTTDCSLFLAERSKFMTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 207 bp

>T149484 NZ_CP064117:2331631-2332089 [Yersinia pestis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin


Download         Length: 62 bp

>AT149484 NZ_CP048440:34367-34428 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References