145918

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 430996..431555 Replicon chromosome
Accession NZ_CP047306
Organism Vibrio cholerae O37 strain ATCC 25872

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GTH07_RS15690 Protein ID WP_000578476.1
Coordinates 430996..431274 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GTH07_RS15695 Protein ID WP_000381183.1
Coordinates 431271..431555 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTH07_RS15645 (GTH07_15725) 426296..426733 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GTH07_RS15650 (GTH07_15730) 426794..427015 + 222 Protein_482 GNAT family N-acetyltransferase -
GTH07_RS15655 (GTH07_15735) 427190..428062 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GTH07_RS15660 (GTH07_15740) 428212..428811 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GTH07_RS15665 (GTH07_15745) 428868..428936 + 69 Protein_485 acetyltransferase -
GTH07_RS15670 (GTH07_15750) 429003..429272 + 270 WP_001114075.1 DUF4160 domain-containing protein -
GTH07_RS15675 (GTH07_15755) 429266..429787 + 522 WP_000921691.1 DUF2442 domain-containing protein -
GTH07_RS15680 (GTH07_15760) 430086..430211 + 126 WP_001905700.1 DUF645 family protein -
GTH07_RS15685 (GTH07_15765) 430462..430857 + 396 WP_001000867.1 hypothetical protein -
GTH07_RS15690 (GTH07_15770) 430996..431274 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GTH07_RS15695 (GTH07_15775) 431271..431555 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTH07_RS15700 (GTH07_15780) 431749..432264 + 516 WP_000343779.1 GNAT family protein -
GTH07_RS15705 (GTH07_15790) 432448..432861 + 414 WP_000049420.1 VOC family protein -
GTH07_RS15710 (GTH07_15800) 433416..434593 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 307620..433724 126104
- inside Integron - - 312700..433348 120648
flank IS/Tn - - 426296..426733 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145918 WP_000578476.1 NZ_CP047306:c431274-430996 [Vibrio cholerae O37]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145918 NZ_CP062708:c5060537-5060364 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145918 WP_000381183.1 NZ_CP047306:c431555-431271 [Vibrio cholerae O37]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145918 NZ_CP062708:c5060861-5060565 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References