Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 423120..423667 | Replicon | chromosome |
| Accession | NZ_CP047306 | ||
| Organism | Vibrio cholerae O37 strain ATCC 25872 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q9KM92 |
| Locus tag | GTH07_RS15620 | Protein ID | WP_000229317.1 |
| Coordinates | 423365..423667 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | GTH07_RS15615 | Protein ID | WP_000861987.1 |
| Coordinates | 423120..423377 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GTH07_RS15570 (GTH07_15645) | 418148..418603 | + | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
| GTH07_RS18730 | 418660..418782 | + | 123 | Protein_464 | acetyltransferase | - |
| GTH07_RS15575 (GTH07_15650) | 418953..419077 | + | 125 | Protein_465 | DUF645 family protein | - |
| GTH07_RS15580 (GTH07_15655) | 419280..419777 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| GTH07_RS15585 (GTH07_15660) | 419774..420046 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| GTH07_RS18735 | 420198..420260 | + | 63 | Protein_468 | acetyltransferase | - |
| GTH07_RS15590 (GTH07_15665) | 420277..420945 | + | 669 | WP_000043871.1 | hypothetical protein | - |
| GTH07_RS15595 (GTH07_15670) | 421097..421384 | + | 288 | WP_000426470.1 | hypothetical protein | - |
| GTH07_RS15600 (GTH07_15675) | 421525..421896 | + | 372 | WP_001164080.1 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
| GTH07_RS18740 (GTH07_15680) | 422119..422388 | + | 270 | WP_000179600.1 | DUF1778 domain-containing protein | - |
| GTH07_RS15610 (GTH07_15685) | 422385..422918 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
| GTH07_RS18745 (GTH07_15690) | 422928..423038 | + | 111 | WP_086010065.1 | DUF3265 domain-containing protein | - |
| GTH07_RS15615 (GTH07_15695) | 423120..423377 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GTH07_RS15620 (GTH07_15700) | 423365..423667 | + | 303 | WP_000229317.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GTH07_RS15625 (GTH07_15705) | 423901..424818 | + | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
| GTH07_RS15630 (GTH07_15710) | 425026..425268 | + | 243 | WP_000107462.1 | hypothetical protein | - |
| GTH07_RS15635 (GTH07_15715) | 425443..425832 | + | 390 | WP_001081302.1 | hypothetical protein | - |
| GTH07_RS15640 (GTH07_15720) | 425968..426177 | + | 210 | Protein_480 | GNAT family N-acetyltransferase | - |
| GTH07_RS15645 (GTH07_15725) | 426296..426733 | + | 438 | WP_000503169.1 | IS200/IS605-like element IS1004 family transposase | - |
| GTH07_RS15650 (GTH07_15730) | 426794..427015 | + | 222 | Protein_482 | GNAT family N-acetyltransferase | - |
| GTH07_RS15655 (GTH07_15735) | 427190..428062 | + | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 307620..433724 | 126104 | |
| - | inside | Integron | - | - | 312700..433348 | 120648 | |
| flank | IS/Tn | - | - | 426296..426733 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11726.68 Da Isoelectric Point: 5.1972
>T145916 WP_000229317.1 NZ_CP047306:423365-423667 [Vibrio cholerae O37]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T145916 NZ_CP062708:4829169-4829510 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT145916 WP_000861987.1 NZ_CP047306:423120-423377 [Vibrio cholerae O37]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT145916 NZ_CP062708:c4829174-4829098 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9KM92 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SLM9 |