Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 423120..423667 Replicon chromosome
Accession NZ_CP047306
Organism Vibrio cholerae O37 strain ATCC 25872

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GTH07_RS15620 Protein ID WP_000229317.1
Coordinates 423365..423667 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GTH07_RS15615 Protein ID WP_000861987.1
Coordinates 423120..423377 (+) Length 86 a.a.

Genomic Context

GTH07_RS15570GTH07_RS18730GTH07_RS15575GTH07_RS18735GTH07_RS15590GTH07_RS15595GTH07_RS15600GTH07_RS18740GTH07_RS15610GTH07_RS18745GTH07_RS15615GTH07_RS15620GTH07_RS15625GTH07_RS15630GTH07_RS15635GTH07_RS15640GTH07_RS15645GTH07_RS15650GTH07_RS15655GTH07_RS15580GTH07_RS15585
Location: 418148..418603 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 418660..418782 (123 bp)
Type: Others
Protein ID: Protein_464
Location: 418953..419077 (125 bp)
Type: Others
Protein ID: Protein_465
Location: 420198..420260 (63 bp)
Type: Others
Protein ID: Protein_468
Location: 420277..420945 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421097..421384 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 421525..421896 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 422119..422388 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 422385..422918 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 422928..423038 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 423120..423377 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 423365..423667 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 423901..424818 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 425026..425268 (243 bp)
Type: Others
Protein ID: WP_000107462.1
Location: 425443..425832 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 425968..426177 (210 bp)
Type: Others
Protein ID: Protein_480
Location: 426296..426733 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 426794..427015 (222 bp)
Type: Others
Protein ID: Protein_482
Location: 427190..428062 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 419280..419777 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 419774..420046 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTH07_RS15570 (GTH07_15645)418148..418603+456WP_001245327.1GNAT family N-acetyltransferase-
GTH07_RS18730418660..418782+123Protein_464acetyltransferase-
GTH07_RS15575 (GTH07_15650)418953..419077+125Protein_465DUF645 family protein-
GTH07_RS15580 (GTH07_15655)419280..419777-498WP_000982260.1GNAT family N-acetyltransferase-
GTH07_RS15585 (GTH07_15660)419774..420046-273WP_000246253.1DUF1778 domain-containing protein-
GTH07_RS18735420198..420260+63Protein_468acetyltransferase-
GTH07_RS15590 (GTH07_15665)420277..420945+669WP_000043871.1hypothetical protein-
GTH07_RS15595 (GTH07_15670)421097..421384+288WP_000426470.1hypothetical protein-
GTH07_RS15600 (GTH07_15675)421525..421896+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
GTH07_RS18740 (GTH07_15680)422119..422388+270WP_000179600.1DUF1778 domain-containing protein-
GTH07_RS15610 (GTH07_15685)422385..422918+534WP_000118351.1GNAT family N-acetyltransferase-
GTH07_RS18745 (GTH07_15690)422928..423038+111WP_086010065.1DUF3265 domain-containing protein-
GTH07_RS15615 (GTH07_15695)423120..423377+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GTH07_RS15620 (GTH07_15700)423365..423667+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTH07_RS15625 (GTH07_15705)423901..424818+918WP_000186333.1alpha/beta hydrolase-
GTH07_RS15630 (GTH07_15710)425026..425268+243WP_000107462.1hypothetical protein-
GTH07_RS15635 (GTH07_15715)425443..425832+390WP_001081302.1hypothetical protein-
GTH07_RS15640 (GTH07_15720)425968..426177+210Protein_480GNAT family N-acetyltransferase-
GTH07_RS15645 (GTH07_15725)426296..426733+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
GTH07_RS15650 (GTH07_15730)426794..427015+222Protein_482GNAT family N-acetyltransferase-
GTH07_RS15655 (GTH07_15735)427190..428062+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--307620..433724126104
-insideIntegron--312700..433348120648
flankIS/Tn--426296..426733437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145916 WP_000229317.1 NZ_CP047306:423365-423667 [Vibrio cholerae O37]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145916 NZ_CP062708:4829169-4829510 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145916 WP_000861987.1 NZ_CP047306:423120-423377 [Vibrio cholerae O37]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145916 NZ_CP062708:c4829174-4829098 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References