Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 417492..418020 Replicon chromosome
Accession NZ_CP047306
Organism Vibrio cholerae O37 strain ATCC 25872

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag GTH07_RS15565 Protein ID WP_000221354.1
Coordinates 417733..418020 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag GTH07_RS15560 Protein ID WP_001250179.1
Coordinates 417492..417743 (+) Length 84 a.a.

Genomic Context

GTH07_RS15520GTH07_RS15525GTH07_RS15530GTH07_RS15540GTH07_RS18715GTH07_RS18720GTH07_RS15550GTH07_RS18725GTH07_RS15555GTH07_RS15560GTH07_RS15565GTH07_RS15570GTH07_RS18730GTH07_RS15575GTH07_RS18735GTH07_RS15590GTH07_RS15595GTH07_RS15600GTH07_RS18740GTH07_RS15610GTH07_RS15535GTH07_RS15580GTH07_RS15585
Location: 412761..413075 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 413212..413646 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 413814..413969 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 415142..415448 (307 bp)
Type: Others
Protein ID: Protein_455
Location: 415585..415983 (399 bp)
Type: Others
Protein ID: Protein_456
Location: 416107..416277 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 416277..416678 (402 bp)
Type: Others
Protein ID: WP_000351251.1
Location: 416648..416790 (143 bp)
Type: Others
Protein ID: Protein_459
Location: 416865..417278 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 417492..417743 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 417733..418020 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 418148..418603 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 418660..418782 (123 bp)
Type: Others
Protein ID: Protein_464
Location: 418953..419077 (125 bp)
Type: Others
Protein ID: Protein_465
Location: 420198..420260 (63 bp)
Type: Others
Protein ID: Protein_468
Location: 420277..420945 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421097..421384 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 421525..421896 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 422119..422388 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 422385..422918 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 414094..415074 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 419280..419777 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 419774..420046 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTH07_RS15520 (GTH07_15595)412761..413075+315WP_000071008.1DNA-binding transcriptional regulator-
GTH07_RS15525 (GTH07_15600)413212..413646+435WP_000256036.1GNAT family N-acetyltransferase-
GTH07_RS15530 (GTH07_15605)413814..413969+156WP_000751734.1hypothetical protein-
GTH07_RS15535 (GTH07_15610)414094..415074-981WP_000019370.1IS5-like element ISVch5 family transposase-
GTH07_RS15540 (GTH07_15615)415142..415448+307Protein_455CatB-related O-acetyltransferase-
GTH07_RS18715415585..415983+399Protein_456GNAT family N-acetyltransferase-
GTH07_RS18720416107..416277+171WP_001080654.1hypothetical protein-
GTH07_RS15550 (GTH07_15625)416277..416678+402WP_000351251.1type II toxin-antitoxin system death-on-curing family toxin-
GTH07_RS18725416648..416790+143Protein_459DUF3265 domain-containing protein-
GTH07_RS15555 (GTH07_15630)416865..417278+414WP_000049417.1VOC family protein-
GTH07_RS15560 (GTH07_15635)417492..417743+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GTH07_RS15565 (GTH07_15640)417733..418020+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTH07_RS15570 (GTH07_15645)418148..418603+456WP_001245327.1GNAT family N-acetyltransferase-
GTH07_RS18730418660..418782+123Protein_464acetyltransferase-
GTH07_RS15575 (GTH07_15650)418953..419077+125Protein_465DUF645 family protein-
GTH07_RS15580 (GTH07_15655)419280..419777-498WP_000982260.1GNAT family N-acetyltransferase-
GTH07_RS15585 (GTH07_15660)419774..420046-273WP_000246253.1DUF1778 domain-containing protein-
GTH07_RS18735420198..420260+63Protein_468acetyltransferase-
GTH07_RS15590 (GTH07_15665)420277..420945+669WP_000043871.1hypothetical protein-
GTH07_RS15595 (GTH07_15670)421097..421384+288WP_000426470.1hypothetical protein-
GTH07_RS15600 (GTH07_15675)421525..421896+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
GTH07_RS18740 (GTH07_15680)422119..422388+270WP_000179600.1DUF1778 domain-containing protein-
GTH07_RS15610 (GTH07_15685)422385..422918+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--307620..433724126104
-insideIntegron--312700..433348120648
flankIS/Tn--414094..415074980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T145913 WP_000221354.1 NZ_CP047306:417733-418020 [Vibrio cholerae O37]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T145913 NZ_CP062708:c4475591-4475193 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT145913 WP_001250179.1 NZ_CP047306:417492-417743 [Vibrio cholerae O37]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT145913 NZ_CP062708:c4475887-4475594 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References