Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 416107..416678 Replicon chromosome
Accession NZ_CP047306
Organism Vibrio cholerae O37 strain ATCC 25872

Toxin (Protein)


Gene name doc Uniprot ID A0A0F2H0W6
Locus tag GTH07_RS15550 Protein ID WP_000351251.1
Coordinates 416277..416678 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag GTH07_RS18720 Protein ID WP_001080654.1
Coordinates 416107..416277 (+) Length 57 a.a.

Genomic Context

GTH07_RS15495GTH07_RS15500GTH07_RS15505GTH07_RS15510GTH07_RS15515GTH07_RS15520GTH07_RS15525GTH07_RS15530GTH07_RS15540GTH07_RS18715GTH07_RS18720GTH07_RS15550GTH07_RS18725GTH07_RS15555GTH07_RS15560GTH07_RS15565GTH07_RS15570GTH07_RS18730GTH07_RS15575GTH07_RS18735GTH07_RS15590GTH07_RS15595GTH07_RS15535GTH07_RS15580GTH07_RS15585
Location: 411302..411416 (115 bp)
Type: Others
Protein ID: Protein_446
Location: 411425..411646 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 411812..411925 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 411874..412101 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 412442..412774 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 412761..413075 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 413212..413646 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 413814..413969 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 415142..415448 (307 bp)
Type: Others
Protein ID: Protein_455
Location: 415585..415983 (399 bp)
Type: Others
Protein ID: Protein_456
Location: 416107..416277 (171 bp)
Type: Antitoxin
Protein ID: WP_001080654.1
Location: 416277..416678 (402 bp)
Type: Toxin
Protein ID: WP_000351251.1
Location: 416648..416790 (143 bp)
Type: Others
Protein ID: Protein_459
Location: 416865..417278 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 417492..417743 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 417733..418020 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 418148..418603 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 418660..418782 (123 bp)
Type: Others
Protein ID: Protein_464
Location: 418953..419077 (125 bp)
Type: Others
Protein ID: Protein_465
Location: 420198..420260 (63 bp)
Type: Others
Protein ID: Protein_468
Location: 420277..420945 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421097..421384 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 414094..415074 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 419280..419777 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 419774..420046 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTH07_RS15495411302..411416+115Protein_446acetyltransferase-
GTH07_RS15500 (GTH07_15565)411425..411646+222WP_032468461.1DUF1289 domain-containing protein-
GTH07_RS15505 (GTH07_15575)411812..411925+114WP_001889158.1hypothetical protein-
GTH07_RS15510 (GTH07_15580)411874..412101+228WP_001894457.1DUF1289 domain-containing protein-
GTH07_RS15515 (GTH07_15590)412442..412774+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
GTH07_RS15520 (GTH07_15595)412761..413075+315WP_000071008.1DNA-binding transcriptional regulator-
GTH07_RS15525 (GTH07_15600)413212..413646+435WP_000256036.1GNAT family N-acetyltransferase-
GTH07_RS15530 (GTH07_15605)413814..413969+156WP_000751734.1hypothetical protein-
GTH07_RS15535 (GTH07_15610)414094..415074-981WP_000019370.1IS5-like element ISVch5 family transposase-
GTH07_RS15540 (GTH07_15615)415142..415448+307Protein_455CatB-related O-acetyltransferase-
GTH07_RS18715415585..415983+399Protein_456GNAT family N-acetyltransferase-
GTH07_RS18720416107..416277+171WP_001080654.1hypothetical proteinAntitoxin
GTH07_RS15550 (GTH07_15625)416277..416678+402WP_000351251.1type II toxin-antitoxin system death-on-curing family toxinToxin
GTH07_RS18725416648..416790+143Protein_459DUF3265 domain-containing protein-
GTH07_RS15555 (GTH07_15630)416865..417278+414WP_000049417.1VOC family protein-
GTH07_RS15560 (GTH07_15635)417492..417743+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTH07_RS15565 (GTH07_15640)417733..418020+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GTH07_RS15570 (GTH07_15645)418148..418603+456WP_001245327.1GNAT family N-acetyltransferase-
GTH07_RS18730418660..418782+123Protein_464acetyltransferase-
GTH07_RS15575 (GTH07_15650)418953..419077+125Protein_465DUF645 family protein-
GTH07_RS15580 (GTH07_15655)419280..419777-498WP_000982260.1GNAT family N-acetyltransferase-
GTH07_RS15585 (GTH07_15660)419774..420046-273WP_000246253.1DUF1778 domain-containing protein-
GTH07_RS18735420198..420260+63Protein_468acetyltransferase-
GTH07_RS15590 (GTH07_15665)420277..420945+669WP_000043871.1hypothetical protein-
GTH07_RS15595 (GTH07_15670)421097..421384+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--307620..433724126104
-insideIntegron--312700..433348120648
flankIS/Tn--414094..415074980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(10-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14574.70 Da        Isoelectric Point: 4.0128

>T145912 WP_000351251.1 NZ_CP047306:416277-416678 [Vibrio cholerae O37]
MDIICFPFERVIEINALILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T145912 NZ_CP062708:4218091-4218309 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT145912 WP_001080654.1 NZ_CP047306:416107-416277 [Vibrio cholerae O37]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT145912 NZ_CP062708:4217691-4218065 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2H0W6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SJJ1

References