Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 15231..16324 Replicon chromosome
Accession NZ_CP046845
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GPY04_RS14110 Protein ID WP_000351248.1
Coordinates 15231..15632 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GPY04_RS14115 Protein ID WP_001047169.1
Coordinates 15632..16324 (-) Length 231 a.a.

Genomic Context

GPY04_RS14065GPY04_RS14070GPY04_RS14125GPY04_RS14055GPY04_RS14060GPY04_RS14080GPY04_RS14085GPY04_RS14090GPY04_RS14095GPY04_RS14100GPY04_RS14105GPY04_RS14110GPY04_RS14115GPY04_RS14120GPY04_RS14130GPY04_RS14135GPY04_RS14140GPY04_RS14145GPY04_RS14155GPY04_RS14160GPY04_RS14170GPY04_RS19350GPY04_RS14175
Location: 11863..12135 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 12132..12629 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 16835..17815 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 10525..10812 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 10964..11632 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 12831..12983 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 13305..13760 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 13888..14175 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 14165..14416 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 14630..15043 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 15118..15261 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 15231..15632 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 15632..16324 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 16461..16767 (307 bp)
Type: Others
Protein ID: Protein_32
Location: 17940..18095 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 18263..18697 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 18834..19148 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 19135..19467 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 19808..20035 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 19984..20097 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 20263..20544 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 20493..20607 (115 bp)
Type: Others
Protein ID: Protein_41
Location: 20664..21041 (378 bp)
Type: Others
Protein ID: WP_000411109.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY04_RS1405510525..10812-288WP_000426470.1hypothetical protein-
GPY04_RS1406010964..11632-669WP_000043871.1hypothetical protein-
GPY04_RS1406511863..12135+273WP_000246253.1DUF1778 domain-containing protein-
GPY04_RS1407012132..12629+498WP_000982260.1GNAT family N-acetyltransferase-
GPY04_RS1408012831..12983-153WP_001884520.1DUF645 family protein-
GPY04_RS1408513305..13760-456WP_001245327.1GNAT family N-acetyltransferase-
GPY04_RS1409013888..14175-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY04_RS1409514165..14416-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPY04_RS1410014630..15043-414WP_000049417.1VOC family protein-
GPY04_RS1410515118..15261-144WP_071908341.1DUF3265 domain-containing protein-
GPY04_RS1411015231..15632-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
GPY04_RS1411515632..16324-693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
GPY04_RS1412016461..16767-307Protein_32CatB-related O-acetyltransferase-
GPY04_RS1412516835..17815+981WP_000019370.1IS5-like element ISVch5 family transposase-
GPY04_RS1413017940..18095-156WP_000751734.1hypothetical protein-
GPY04_RS1413518263..18697-435WP_000256036.1GNAT family N-acetyltransferase-
GPY04_RS1414018834..19148-315WP_000071008.1DNA-binding transcriptional regulator-
GPY04_RS1414519135..19467-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY04_RS1415519808..20035-228WP_001894457.1DUF1289 domain-containing protein-
GPY04_RS1416019984..20097-114WP_001889158.1hypothetical protein-
GPY04_RS1417020263..20544-282WP_001894453.1DUF1289 domain-containing protein-
GPY04_RS1935020493..20607-115Protein_41acetyltransferase-
GPY04_RS1417520664..21041-378WP_000411109.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegroncatB9hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA113..10702881070175
flankIS/Tn--16835..17815980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T145081 WP_000351248.1 NZ_CP046845:c15632-15231 [Vibrio cholerae C6706]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T145081 NZ_CP062254:c623192-622941 [Pectobacterium parmentieri]
ATGCGTACAATTAGCTACAGCGAAGCCCGCCAAAACCTATCAGCAACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGCGAAGCCTGTGTGCTGATGTCTCTGGAAGAGTATAACTCTCTAGAAGAAACCGCGTATT
TACTGCGTTCTCCCGCCAATGCCAAAAGACTGATGAATGCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT145081 WP_001047169.1 NZ_CP046845:c16324-15632 [Vibrio cholerae C6706]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT145081 NZ_CP062254:c622944-622690 [Pectobacterium parmentieri]
GTGAAGCCAATCTGGTCAGAAGCAGCATGGGAAGACTACCTGTACTGGCAGGATATCGATAATCGGATAGTCAAAAAAAT
CAATGAATTAATAAAAGAAATTCGCAGAACGCCTTTTGAGGGAAAAGGAAAACCAGAGCCGCTTAAACATAATCTTGCTG
GCTTCTGGTCACGCCGTATCACCGAAGAACATCGTCTGGTCTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References