145080

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 13888..14416 Replicon chromosome
Accession NZ_CP046845
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag GPY04_RS14090 Protein ID WP_000221354.1
Coordinates 13888..14175 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag GPY04_RS14095 Protein ID WP_001250179.1
Coordinates 14165..14416 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY04_RS14040 8991..9524 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
GPY04_RS19345 9521..9946 - 426 WP_001882332.1 DUF1778 domain-containing protein -
GPY04_RS14050 10013..10384 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GPY04_RS14055 10525..10812 - 288 WP_000426470.1 hypothetical protein -
GPY04_RS14060 10964..11632 - 669 WP_000043871.1 hypothetical protein -
GPY04_RS14065 11863..12135 + 273 WP_000246253.1 DUF1778 domain-containing protein -
GPY04_RS14070 12132..12629 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
GPY04_RS14080 12831..12983 - 153 WP_001884520.1 DUF645 family protein -
GPY04_RS14085 13305..13760 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
GPY04_RS14090 13888..14175 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY04_RS14095 14165..14416 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY04_RS14100 14630..15043 - 414 WP_000049417.1 VOC family protein -
GPY04_RS14105 15118..15261 - 144 WP_071908341.1 DUF3265 domain-containing protein -
GPY04_RS14110 15231..15632 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GPY04_RS14115 15632..16324 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
GPY04_RS14120 16461..16767 - 307 Protein_32 CatB-related O-acetyltransferase -
GPY04_RS14125 16835..17815 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GPY04_RS14130 17940..18095 - 156 WP_000751734.1 hypothetical protein -
GPY04_RS14135 18263..18697 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
GPY04_RS14140 18834..19148 - 315 WP_000071008.1 DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron catB9 hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 113..1070288 1070175
flank IS/Tn - - 16835..17815 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T145080 WP_000221354.1 NZ_CP046845:c14175-13888 [Vibrio cholerae C6706]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T145080 NZ_CP046845:c14175-13888 [Vibrio cholerae C6706]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT145080 WP_001250179.1 NZ_CP046845:c14416-14165 [Vibrio cholerae C6706]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT145080 NZ_CP046845:c14416-14165 [Vibrio cholerae C6706]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References