Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 11863..12629 Replicon chromosome
Accession NZ_CP046845
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GPY04_RS14070 Protein ID WP_000982260.1
Coordinates 12132..12629 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GPY04_RS14065 Protein ID WP_000246253.1
Coordinates 11863..12135 (+) Length 91 a.a.

Genomic Context

GPY04_RS14065GPY04_RS14070GPY04_RS14020GPY04_RS14025GPY04_RS14030GPY04_RS14040GPY04_RS19345GPY04_RS14050GPY04_RS14055GPY04_RS14060GPY04_RS14080GPY04_RS14085GPY04_RS14090GPY04_RS14095GPY04_RS14100GPY04_RS14105GPY04_RS14110GPY04_RS14115GPY04_RS14120
Location: 11863..12135 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 12132..12629 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 7091..8008 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 8242..8544 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 8532..8789 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 8991..9524 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 9521..9946 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 10013..10384 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 10525..10812 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 10964..11632 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 12831..12983 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 13305..13760 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 13888..14175 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 14165..14416 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 14630..15043 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 15118..15261 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 15231..15632 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 15632..16324 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 16461..16767 (307 bp)
Type: Others
Protein ID: Protein_32
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY04_RS140207091..8008-918WP_000186333.1alpha/beta hydrolase-
GPY04_RS140258242..8544-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY04_RS140308532..8789-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPY04_RS140408991..9524-534WP_000118351.1GNAT family N-acetyltransferase-
GPY04_RS193459521..9946-426WP_001882332.1DUF1778 domain-containing protein-
GPY04_RS1405010013..10384-372WP_001164080.1nucleotide pyrophosphohydrolase-
GPY04_RS1405510525..10812-288WP_000426470.1hypothetical protein-
GPY04_RS1406010964..11632-669WP_000043871.1hypothetical protein-
GPY04_RS1406511863..12135+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
GPY04_RS1407012132..12629+498WP_000982260.1GNAT family N-acetyltransferaseToxin
GPY04_RS1408012831..12983-153WP_001884520.1DUF645 family protein-
GPY04_RS1408513305..13760-456WP_001245327.1GNAT family N-acetyltransferase-
GPY04_RS1409013888..14175-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY04_RS1409514165..14416-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPY04_RS1410014630..15043-414WP_000049417.1VOC family protein-
GPY04_RS1410515118..15261-144WP_071908341.1DUF3265 domain-containing protein-
GPY04_RS1411015231..15632-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GPY04_RS1411515632..16324-693WP_001047169.1GNAT family N-acetyltransferase-
GPY04_RS1412016461..16767-307Protein_32CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegroncatB9hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA113..10702881070175
flankIS/Tn--16835..17815980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145079 WP_000982260.1 NZ_CP046845:12132-12629 [Vibrio cholerae C6706]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145079 NZ_CP062254:561755-562030 [Pectobacterium parmentieri]
ATGGAAATACGTTGGACGCAAAAGGCACAGGATGACCTTGAACGTATTTATGGGTTTGCCAGCCAGTACAGTCGGCATCA
TGCTGACGAGGTGTTAGATCGCTTGATCATCGGAACCACAGGGATTGCTGACCACCCGAGAATTGGCGTATCTCAGACAA
GATATGAACCACGCGAGGTGAGAAAGATTTTGTTTGATGATTATGAAGTTCACTATGAAATTCAGCACGATACGATTTAT
ATCGTCGATCTTTGGCATACACGAGAAGATCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145079 WP_000246253.1 NZ_CP046845:11863-12135 [Vibrio cholerae C6706]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145079 NZ_CP062254:561503-561751 [Pectobacterium parmentieri]
ATGGGACAACCTGCGAAACAGACGATCAGTGCTCAGATACCCGCCGAACTTGCGGCTGCGGTTGAAAGCCTGGCTATTGA
ATTGGATAGATCCAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCAATGATTGAAGAGAGAGAGCGGCGGCATCAGCGTG
TTTTGAAAGGTCTTGCTGATGTCGATGCGGGAAGAGTAGTAAGCCATGCAGATGTCATCGATTTCGCCAACAAACTGAAA
AAGTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References