Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 11863..12629 | Replicon | chromosome |
| Accession | NZ_CP046845 | ||
| Organism | Vibrio cholerae C6706 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9K2P7 |
| Locus tag | GPY04_RS14070 | Protein ID | WP_000982260.1 |
| Coordinates | 12132..12629 (+) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | Q9K2J6 |
| Locus tag | GPY04_RS14065 | Protein ID | WP_000246253.1 |
| Coordinates | 11863..12135 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY04_RS14020 | 7091..8008 | - | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
| GPY04_RS14025 | 8242..8544 | - | 303 | WP_000229317.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY04_RS14030 | 8532..8789 | - | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY04_RS14040 | 8991..9524 | - | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS19345 | 9521..9946 | - | 426 | WP_001882332.1 | DUF1778 domain-containing protein | - |
| GPY04_RS14050 | 10013..10384 | - | 372 | WP_001164080.1 | nucleotide pyrophosphohydrolase | - |
| GPY04_RS14055 | 10525..10812 | - | 288 | WP_000426470.1 | hypothetical protein | - |
| GPY04_RS14060 | 10964..11632 | - | 669 | WP_000043871.1 | hypothetical protein | - |
| GPY04_RS14065 | 11863..12135 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | Antitoxin |
| GPY04_RS14070 | 12132..12629 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | Toxin |
| GPY04_RS14080 | 12831..12983 | - | 153 | WP_001884520.1 | DUF645 family protein | - |
| GPY04_RS14085 | 13305..13760 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS14090 | 13888..14175 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY04_RS14095 | 14165..14416 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY04_RS14100 | 14630..15043 | - | 414 | WP_000049417.1 | VOC family protein | - |
| GPY04_RS14105 | 15118..15261 | - | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14110 | 15231..15632 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| GPY04_RS14115 | 15632..16324 | - | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS14120 | 16461..16767 | - | 307 | Protein_32 | CatB-related O-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | catB9 | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 113..1070288 | 1070175 | |
| flank | IS/Tn | - | - | 16835..17815 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18527.18 Da Isoelectric Point: 8.7753
>T145079 WP_000982260.1 NZ_CP046845:12132-12629 [Vibrio cholerae C6706]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T145079 NZ_CP062254:561755-562030 [Pectobacterium parmentieri]
ATGGAAATACGTTGGACGCAAAAGGCACAGGATGACCTTGAACGTATTTATGGGTTTGCCAGCCAGTACAGTCGGCATCA
TGCTGACGAGGTGTTAGATCGCTTGATCATCGGAACCACAGGGATTGCTGACCACCCGAGAATTGGCGTATCTCAGACAA
GATATGAACCACGCGAGGTGAGAAAGATTTTGTTTGATGATTATGAAGTTCACTATGAAATTCAGCACGATACGATTTAT
ATCGTCGATCTTTGGCATACACGAGAAGATCGCTGA
ATGGAAATACGTTGGACGCAAAAGGCACAGGATGACCTTGAACGTATTTATGGGTTTGCCAGCCAGTACAGTCGGCATCA
TGCTGACGAGGTGTTAGATCGCTTGATCATCGGAACCACAGGGATTGCTGACCACCCGAGAATTGGCGTATCTCAGACAA
GATATGAACCACGCGAGGTGAGAAAGATTTTGTTTGATGATTATGAAGTTCACTATGAAATTCAGCACGATACGATTTAT
ATCGTCGATCTTTGGCATACACGAGAAGATCGCTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 9683.22 Da Isoelectric Point: 6.2988
>AT145079 WP_000246253.1 NZ_CP046845:11863-12135 [Vibrio cholerae C6706]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT145079 NZ_CP062254:561503-561751 [Pectobacterium parmentieri]
ATGGGACAACCTGCGAAACAGACGATCAGTGCTCAGATACCCGCCGAACTTGCGGCTGCGGTTGAAAGCCTGGCTATTGA
ATTGGATAGATCCAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCAATGATTGAAGAGAGAGAGCGGCGGCATCAGCGTG
TTTTGAAAGGTCTTGCTGATGTCGATGCGGGAAGAGTAGTAAGCCATGCAGATGTCATCGATTTCGCCAACAAACTGAAA
AAGTCATAA
ATGGGACAACCTGCGAAACAGACGATCAGTGCTCAGATACCCGCCGAACTTGCGGCTGCGGTTGAAAGCCTGGCTATTGA
ATTGGATAGATCCAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCAATGATTGAAGAGAGAGAGCGGCGGCATCAGCGTG
TTTTGAAAGGTCTTGCTGATGTCGATGCGGGAAGAGTAGTAAGCCATGCAGATGTCATCGATTTCGCCAACAAACTGAAA
AAGTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0KGB1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F2IC79 |