Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 8991..9946 Replicon chromosome
Accession NZ_CP046845
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag GPY04_RS14040 Protein ID WP_000118351.1
Coordinates 8991..9524 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GPY04_RS19345 Protein ID WP_001882332.1
Coordinates 9521..9946 (-) Length 142 a.a.

Genomic Context

GPY04_RS14065GPY04_RS14070GPY04_RS13995GPY04_RS14000GPY04_RS14005GPY04_RS14010GPY04_RS14015GPY04_RS14020GPY04_RS14025GPY04_RS14030GPY04_RS14040GPY04_RS19345GPY04_RS14050GPY04_RS14055GPY04_RS14060GPY04_RS14080GPY04_RS14085GPY04_RS14090GPY04_RS14095
Location: 11863..12135 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 12132..12629 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 4315..5187 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 5362..5580 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 5644..6081 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 6200..6409 (210 bp)
Type: Others
Protein ID: Protein_12
Location: 6545..6934 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 7091..8008 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 8242..8544 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 8532..8789 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 8991..9524 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 9521..9946 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 10013..10384 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 10525..10812 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 10964..11632 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 12831..12983 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 13305..13760 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 13888..14175 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 14165..14416 (252 bp)
Type: Others
Protein ID: WP_001250179.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY04_RS139954315..5187-873WP_000254716.1DUF3800 domain-containing protein-
GPY04_RS140005362..5580-219WP_071908318.1GNAT family N-acetyltransferase-
GPY04_RS140055644..6081-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
GPY04_RS140106200..6409-210Protein_12GNAT family N-acetyltransferase-
GPY04_RS140156545..6934-390WP_001081302.1hypothetical protein-
GPY04_RS140207091..8008-918WP_000186333.1alpha/beta hydrolase-
GPY04_RS140258242..8544-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY04_RS140308532..8789-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPY04_RS140408991..9524-534WP_000118351.1GNAT family N-acetyltransferaseToxin
GPY04_RS193459521..9946-426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
GPY04_RS1405010013..10384-372WP_001164080.1nucleotide pyrophosphohydrolase-
GPY04_RS1405510525..10812-288WP_000426470.1hypothetical protein-
GPY04_RS1406010964..11632-669WP_000043871.1hypothetical protein-
GPY04_RS1406511863..12135+273WP_000246253.1DUF1778 domain-containing protein-
GPY04_RS1407012132..12629+498WP_000982260.1GNAT family N-acetyltransferase-
GPY04_RS1408012831..12983-153WP_001884520.1DUF645 family protein-
GPY04_RS1408513305..13760-456WP_001245327.1GNAT family N-acetyltransferase-
GPY04_RS1409013888..14175-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GPY04_RS1409514165..14416-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegroncatB9hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA113..10702881070175
flankIS/Tn--5644..6081437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T145078 WP_000118351.1 NZ_CP046845:c9524-8991 [Vibrio cholerae C6706]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T145078 NZ_CP062254:560122-560442 [Pectobacterium parmentieri]
ATGCAAACATCACCTGCAATCCCGCCACGGGAGGATAACCCCTGTCCGTCACCCATAGCCGCCTGGCAGCAACTGCTGAC
CTACCTGCTGGAAAAGCACTACGGCCTGACGCTGAACGACACGCCGTTCTGTGAGGAAAACGTGATTCAGGAACATATCG
ATGCTGGCATCACATTGGTCAATGCCGTGAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGACCGCGACGGTTTT
AACTGGCAGGAGCAATCACCGTTTCTTACTGCCGTTGATGTTCTCCGTGCCAGACGTGCTAACGGCTTGCTCAAAGCATA
A

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT145078 WP_001882332.1 NZ_CP046845:c9946-9521 [Vibrio cholerae C6706]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT145078 NZ_CP062254:559728-560063 [Pectobacterium parmentieri]
ATGTCATTATCGGATACCCCGGAATGGGGACTAAAAAGTGCCATCACTCCGCGATTCGGAGCCAGACTGGTGCAGGAGGG
TAACCGTCTGCATTATCTGGCAGACCGGGTCAGCTTTATCGGTACGTTTAGCAAAACAGAAGCCCAAAGTCTGGAACGTT
GCTTCCCTGAGCTAATTAAGCTGTTGGAACAGAAGCTACGCATGGGGGAACTGAATCCCCGGCAGCAGGGTTGCATCACG
TTGTATTGCAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTTTTGGCTACGTGTATATTGCTATTTATCCCTCTTC
AGCGGCAACACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References