145077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 8242..8789 Replicon chromosome
Accession NZ_CP046845
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GPY04_RS14025 Protein ID WP_000229317.1
Coordinates 8242..8544 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GPY04_RS14030 Protein ID WP_000861987.1
Coordinates 8532..8789 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY04_RS13985 3405..3509 - 105 WP_099607150.1 acetyltransferase -
GPY04_RS13990 3566..4165 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GPY04_RS13995 4315..5187 - 873 WP_000254716.1 DUF3800 domain-containing protein -
GPY04_RS14000 5362..5580 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
GPY04_RS14005 5644..6081 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GPY04_RS14010 6200..6409 - 210 Protein_12 GNAT family N-acetyltransferase -
GPY04_RS14015 6545..6934 - 390 WP_001081302.1 hypothetical protein -
GPY04_RS14020 7091..8008 - 918 WP_000186333.1 alpha/beta hydrolase -
GPY04_RS14025 8242..8544 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY04_RS14030 8532..8789 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY04_RS14040 8991..9524 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
GPY04_RS19345 9521..9946 - 426 WP_001882332.1 DUF1778 domain-containing protein -
GPY04_RS14050 10013..10384 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GPY04_RS14055 10525..10812 - 288 WP_000426470.1 hypothetical protein -
GPY04_RS14060 10964..11632 - 669 WP_000043871.1 hypothetical protein -
GPY04_RS14065 11863..12135 + 273 WP_000246253.1 DUF1778 domain-containing protein -
GPY04_RS14070 12132..12629 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
GPY04_RS14080 12831..12983 - 153 WP_001884520.1 DUF645 family protein -
GPY04_RS14085 13305..13760 - 456 WP_001245327.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron catB9 hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 113..1070288 1070175
flank IS/Tn - - 5644..6081 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145077 WP_000229317.1 NZ_CP046845:c8544-8242 [Vibrio cholerae C6706]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145077 NZ_CP062254:489553-489858 [Pectobacterium parmentieri]
GTGTTCTCCCGTGCACCTTTTGACACTGCAATCGCCCAATTCCCGAATCAGGCGGCAGCACTGGCTGACCTATACCGGAC
GATAAAGCGTGAAATATATGCAACGCCGGACGATATGAAAAAACGTTTCCCCAGCTTAGACAGGATGAAGTACAGGGAAA
AGTGGTGGGTTATTGATATTGGTGGTGGGCATCTTCGGGTGATGTTTTTCGCTGATTTTGAGCGAGGGAAAATTTTTATC
AAACACATCACATCCCATGCAGAGTACGGCAGTCTGACAGAATATTACCGGAGGAATAAAGAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145077 WP_000861987.1 NZ_CP046845:c8789-8532 [Vibrio cholerae C6706]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145077 NZ_CP062254:489855-490178 [Pectobacterium parmentieri]
ATGATGTACGCAGACGCAATCAAGGCCGCTAACAATCTGACGAGTATCGTACCGCTCCTCGGAGGTAGCACCTCTTGTAA
AGATTATGAGGATGCGCCAGAGTTTGTAGCTTTCAACGAGCGTATTAAAGCGCTCCCTGCTGGTATCGCTTTGCTGCGCA
TACTTATGGATCAGCATGGGCTAACGCAAAGTGACTTTGAAGCTGAGATCGGTAAAAAATCTCTGGTATCCCGAATTCTA
AATGGTGAGCGTACACTAACGGTTGATCACATGAGCGCACTTGCTAAACGATTTGATATTCCCGTGAGTGCTTTTGTTGA
TTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References