145075

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 2590..3374 Replicon chromosome
Accession NZ_CP046845
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GPY04_RS13980 Protein ID WP_001114075.1
Coordinates 3105..3374 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag GPY04_RS13975 Protein ID WP_000921691.1
Coordinates 2590..3111 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY04_RS13945 113..628 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
GPY04_RS13950 822..1106 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GPY04_RS13955 1103..1381 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GPY04_RS13960 1520..1915 - 396 WP_001000867.1 hypothetical protein -
GPY04_RS13970 2166..2291 - 126 WP_001905700.1 DUF645 family protein -
GPY04_RS13975 2590..3111 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
GPY04_RS13980 3105..3374 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
GPY04_RS13985 3405..3509 - 105 WP_099607150.1 acetyltransferase -
GPY04_RS13990 3566..4165 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GPY04_RS13995 4315..5187 - 873 WP_000254716.1 DUF3800 domain-containing protein -
GPY04_RS14000 5362..5580 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
GPY04_RS14005 5644..6081 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GPY04_RS14010 6200..6409 - 210 Protein_12 GNAT family N-acetyltransferase -
GPY04_RS14015 6545..6934 - 390 WP_001081302.1 hypothetical protein -
GPY04_RS14020 7091..8008 - 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron catB9 hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 113..1070288 1070175
flank IS/Tn - - 5644..6081 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T145075 WP_001114075.1 NZ_CP046845:c3374-3105 [Vibrio cholerae C6706]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T145075 NZ_CP062253:5657403-5657681 [Pseudomonas gozinkensis]
ATGATCAAATCCTTTCAGCACAAAGGCCTTCGCGGCTTCTATGAAACCGGTTCGACTCGCGGGATTCGTGCCGATCACGC
TAAACGGCTGTCGCGCATGCTGCAGTTCATGGATCGGGCCGCCGTTCCGGGGGATCTGGATCTTCCCGGTTGGCGTATGC
ATCCACTGAAAGGGGAGCTTTGCGAGTACTGGTCACTCAGTGTGTCCGGGAACTGGCGGGTTATCTTTCGATTTGCAGGT
TCGGATATCGAACTGATCGACTATCTGGATTACCACTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT145075 WP_000921691.1 NZ_CP046845:c3111-2590 [Vibrio cholerae C6706]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT145075 NZ_CP062253:5657696-5657983 [Pseudomonas gozinkensis]
ATGCCCATGCACAACCCGCCACACCCCGGTGAAACACTGTTGATGGATGTATTGCCGGAACTTGGCATCAGCGTTACCGA
ATTGGCTCGGCATCTGGGATTCGCTCGTCCTCATCTATCTCGCGTCTTGCACGGACATGCGCCGATCAGCCCGGATCTGG
CCGTACGACTGGAACGCGCGGGGATTGGCAAGGCTCGCATGTGGCTAGGGGTTCAAACAGATTACGACCTCTGGCAAGCC
GAGCATCGTGAGCAACCAGCCATTCAGCCAATCGCTGCTCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References