Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE-RelB |
Location | 822..1381 | Replicon | chromosome |
Accession | NZ_CP046845 | ||
Organism | Vibrio cholerae C6706 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q9K2M8 |
Locus tag | GPY04_RS13955 | Protein ID | WP_000578476.1 |
Coordinates | 1103..1381 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9L991 |
Locus tag | GPY04_RS13950 | Protein ID | WP_000381183.1 |
Coordinates | 822..1106 (+) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GPY04_RS13945 | 113..628 | - | 516 | WP_000343779.1 | GNAT family N-acetyltransferase | - |
GPY04_RS13950 | 822..1106 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
GPY04_RS13955 | 1103..1381 | + | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
GPY04_RS13960 | 1520..1915 | - | 396 | WP_001000867.1 | hypothetical protein | - |
GPY04_RS13970 | 2166..2291 | - | 126 | WP_001905700.1 | DUF645 family protein | - |
GPY04_RS13975 | 2590..3111 | - | 522 | WP_000921691.1 | DUF2442 domain-containing protein | - |
GPY04_RS13980 | 3105..3374 | - | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
GPY04_RS13985 | 3405..3509 | - | 105 | WP_099607150.1 | acetyltransferase | - |
GPY04_RS13990 | 3566..4165 | - | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
GPY04_RS13995 | 4315..5187 | - | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
GPY04_RS14000 | 5362..5580 | - | 219 | WP_071908318.1 | GNAT family N-acetyltransferase | - |
GPY04_RS14005 | 5644..6081 | - | 438 | WP_000503169.1 | IS200/IS605-like element IS1004 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integron | catB9 | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 113..1070288 | 1070175 | |
flank | IS/Tn | - | - | 5644..6081 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T145074 WP_000578476.1 NZ_CP046845:1103-1381 [Vibrio cholerae C6706]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T145074 NZ_CP062253:c5382525-5382181 [Pseudomonas gozinkensis]
ATGAGAACAGTATTCTTTGAAACCACACTATTCACCGCAAACCTGGGTCACTACCTCACGGACGACGAATATCGTGAGCT
GCAGACCTACATGCAAAGCAATCCGCATGCGGGCGATGTCATGCCACGAACAGGCGGCTTCCGAAAATTGCGTTGGGTTG
ATGTTCGTCGTGGCAAGGGCAGGCGAGGCGGCTTGCGAGTTATCTATTATTGGCTTATGAATGATGGCCAGTTCTGGATG
TTTGCGATTTATGACAAAGATGAGCTTGAGAATTTGACCGCCGAGCAAGAGAAGGCGCTCAAGGGAGCTATAGAGAAAGA
GTTGAAAACACGAGGTACCCCATGA
ATGAGAACAGTATTCTTTGAAACCACACTATTCACCGCAAACCTGGGTCACTACCTCACGGACGACGAATATCGTGAGCT
GCAGACCTACATGCAAAGCAATCCGCATGCGGGCGATGTCATGCCACGAACAGGCGGCTTCCGAAAATTGCGTTGGGTTG
ATGTTCGTCGTGGCAAGGGCAGGCGAGGCGGCTTGCGAGTTATCTATTATTGGCTTATGAATGATGGCCAGTTCTGGATG
TTTGCGATTTATGACAAAGATGAGCTTGAGAATTTGACCGCCGAGCAAGAGAAGGCGCTCAAGGGAGCTATAGAGAAAGA
GTTGAAAACACGAGGTACCCCATGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT145074 WP_000381183.1 NZ_CP046845:822-1106 [Vibrio cholerae C6706]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT145074 NZ_CP062253:c5382184-5381870 [Pseudomonas gozinkensis]
ATGAAAAAACGCGACCTGTTTGCAGAATTGATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAAGGAAAAATCACGCT
ACGTAATACGACACTTGAGGACAAACCAGCGCCCGAAGTCGGTGCTCAGGAAATCGTAGCGCTACGGGAAAAACTGCACA
TGTCACAGGCGGTTTTTGCCAGGCGAATCAGGACAAGTCCAAGCACCCTTAGAAACTGGGAGCAGGAGAAATCAAAGCCC
AACGCTCAGGCTGCCTTGCTGATCCGTTTGGTGGAAAAATTCCCTGATATGGTCGAGCGATTGAGCGCTGTTTAA
ATGAAAAAACGCGACCTGTTTGCAGAATTGATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAAGGAAAAATCACGCT
ACGTAATACGACACTTGAGGACAAACCAGCGCCCGAAGTCGGTGCTCAGGAAATCGTAGCGCTACGGGAAAAACTGCACA
TGTCACAGGCGGTTTTTGCCAGGCGAATCAGGACAAGTCCAAGCACCCTTAGAAACTGGGAGCAGGAGAAATCAAAGCCC
AACGCTCAGGCTGCCTTGCTGATCCGTTTGGTGGAAAAATTCCCTGATATGGTCGAGCGATTGAGCGCTGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q9K2M8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A067BL33 |