Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 589057..590150 Replicon chromosome
Accession NZ_CP046743
Organism Vibrio cholerae strain 3569-08

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GPW72_RS02720 Protein ID WP_000351248.1
Coordinates 589057..589458 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GPW72_RS02725 Protein ID WP_001047169.1
Coordinates 589458..590150 (-) Length 231 a.a.

Genomic Context

GPW72_RS02675GPW72_RS02680GPW72_RS02735GPW72_RS02665GPW72_RS02670GPW72_RS02690GPW72_RS02695GPW72_RS02700GPW72_RS02705GPW72_RS02710GPW72_RS02715GPW72_RS02720GPW72_RS02725GPW72_RS02730GPW72_RS02740GPW72_RS02745GPW72_RS02750GPW72_RS02755GPW72_RS02765GPW72_RS02770GPW72_RS02780GPW72_RS19175GPW72_RS02785
Location: 585689..585961 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 585958..586455 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 590661..591641 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 584351..584638 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 584790..585458 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 586657..586809 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 587131..587586 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 587714..588001 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 587991..588242 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 588456..588869 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 588944..589087 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 589057..589458 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 589458..590150 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 590287..590593 (307 bp)
Type: Others
Protein ID: Protein_526
Location: 591766..591921 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 592089..592523 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 592660..592974 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 592961..593293 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 593634..593861 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 593810..593923 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 594089..594370 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 594319..594433 (115 bp)
Type: Others
Protein ID: Protein_535
Location: 594490..594867 (378 bp)
Type: Others
Protein ID: WP_000411109.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPW72_RS02665584351..584638-288WP_000426470.1hypothetical protein-
GPW72_RS02670584790..585458-669WP_000043871.1hypothetical protein-
GPW72_RS02675585689..585961+273WP_000246253.1DUF1778 domain-containing protein-
GPW72_RS02680585958..586455+498WP_000982260.1GNAT family N-acetyltransferase-
GPW72_RS02690586657..586809-153WP_001884520.1DUF645 family protein-
GPW72_RS02695587131..587586-456WP_001245327.1GNAT family N-acetyltransferase-
GPW72_RS02700587714..588001-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GPW72_RS02705587991..588242-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GPW72_RS02710588456..588869-414WP_000049417.1VOC family protein-
GPW72_RS02715588944..589087-144WP_071908341.1DUF3265 domain-containing protein-
GPW72_RS02720589057..589458-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
GPW72_RS02725589458..590150-693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
GPW72_RS02730590287..590593-307Protein_526CatB-related O-acetyltransferase-
GPW72_RS02735590661..591641+981WP_000019370.1IS5-like element ISVch5 family transposase-
GPW72_RS02740591766..591921-156WP_000751734.1hypothetical protein-
GPW72_RS02745592089..592523-435WP_000256036.1GNAT family N-acetyltransferase-
GPW72_RS02750592660..592974-315WP_000071008.1DNA-binding transcriptional regulator-
GPW72_RS02755592961..593293-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
GPW72_RS02765593634..593861-228WP_001894457.1DUF1289 domain-containing protein-
GPW72_RS02770593810..593923-114WP_001889158.1hypothetical protein-
GPW72_RS02780594089..594370-282WP_001894453.1DUF1289 domain-containing protein-
GPW72_RS19175594319..594433-115Protein_535acetyltransferase-
GPW72_RS02785594490..594867-378WP_000411109.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--575627..724145148518
-insideIntegron--575627..717201141574
flankIS/Tn--590661..591641980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T144873 WP_000351248.1 NZ_CP046743:c589458-589057 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T144873 NZ_CP062244:c2083194-2082943 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT144873 WP_001047169.1 NZ_CP046743:c590150-589458 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT144873 NZ_CP062244:c2082946-2082692 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References