144871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 585689..586455 Replicon chromosome
Accession NZ_CP046743
Organism Vibrio cholerae strain 3569-08

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GPW72_RS02680 Protein ID WP_000982260.1
Coordinates 585958..586455 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GPW72_RS02675 Protein ID WP_000246253.1
Coordinates 585689..585961 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPW72_RS02630 580913..581797 - 885 WP_000842472.1 DUF3800 domain-containing protein -
GPW72_RS02635 582068..582370 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPW72_RS02640 582358..582615 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPW72_RS02650 582817..583350 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
GPW72_RS19170 583347..583772 - 426 WP_001882332.1 DUF1778 domain-containing protein -
GPW72_RS02660 583839..584210 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GPW72_RS02665 584351..584638 - 288 WP_000426470.1 hypothetical protein -
GPW72_RS02670 584790..585458 - 669 WP_000043871.1 hypothetical protein -
GPW72_RS02675 585689..585961 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
GPW72_RS02680 585958..586455 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GPW72_RS02690 586657..586809 - 153 WP_001884520.1 DUF645 family protein -
GPW72_RS02695 587131..587586 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
GPW72_RS02700 587714..588001 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPW72_RS02705 587991..588242 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPW72_RS02710 588456..588869 - 414 WP_000049417.1 VOC family protein -
GPW72_RS02715 588944..589087 - 144 WP_071908341.1 DUF3265 domain-containing protein -
GPW72_RS02720 589057..589458 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GPW72_RS02725 589458..590150 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
GPW72_RS02730 590287..590593 - 307 Protein_526 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 575627..724145 148518
- inside Integron - - 575627..717201 141574
flank IS/Tn - - 590661..591641 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T144871 WP_000982260.1 NZ_CP046743:585958-586455 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T144871 NZ_CP062244:2071050-2071424 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT144871 WP_000246253.1 NZ_CP046743:585689-585961 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT144871 NZ_CP062244:2070593-2070961 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References