Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-DinJ |
Location | 521490..521975 | Replicon | chromosome |
Accession | NZ_CP046267 | ||
Organism | Lacticaseibacillus rhamnosus strain BIO5326 |
Toxin (Protein)
Gene name | yafQ | Uniprot ID | C2K0Y1 |
Locus tag | GMB04_RS02515 | Protein ID | WP_005691636.1 |
Coordinates | 521490..521675 (-) | Length | 62 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | A0A508YYT1 |
Locus tag | GMB04_RS02520 | Protein ID | WP_014571130.1 |
Coordinates | 521703..521975 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GMB04_RS02490 | 516497..517186 | + | 690 | WP_005691628.1 | rhomboid family intramembrane serine protease | - |
GMB04_RS02495 | 517678..518286 | - | 609 | WP_005691630.1 | hypothetical protein | - |
GMB04_RS02505 | 518733..519608 | + | 876 | WP_025014074.1 | Rgg/GadR/MutR family transcriptional regulator | - |
GMB04_RS02510 | 519851..521266 | - | 1416 | WP_005691634.1 | DNA polymerase III subunit epsilon | - |
GMB04_RS02515 | 521490..521675 | - | 186 | WP_005691636.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
GMB04_RS02520 | 521703..521975 | - | 273 | WP_014571130.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
GMB04_RS02525 | 522537..522785 | + | 249 | WP_005691639.1 | hypothetical protein | - |
GMB04_RS02530 | 523028..523321 | + | 294 | WP_005684269.1 | metalloregulator ArsR/SmtB family transcription factor | - |
GMB04_RS02535 | 523403..524566 | + | 1164 | WP_005691640.1 | MFS transporter | - |
GMB04_RS02540 | 524720..525295 | + | 576 | WP_014571131.1 | DNA-3-methyladenine glycosylase I | - |
GMB04_RS02545 | 525438..526034 | + | 597 | WP_005691643.1 | IS607 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 517678..527700 | 10022 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6781.86 Da Isoelectric Point: 7.4698
>T143788 WP_005691636.1 NZ_CP046267:c521675-521490 [Lacticaseibacillus rhamnosus]
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE
MQRQGHVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALILMLLATGTHRDTLNIE
Download Length: 186 bp
>T143788 NZ_CP061367:4442100-4442318 [Shigella sonnei]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10005.62 Da Isoelectric Point: 9.5939
>AT143788 WP_014571130.1 NZ_CP046267:c521975-521703 [Lacticaseibacillus rhamnosus]
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD
MTKKSRISVRIDTKTKERALHVLNSMGLDISSAINMYLKRIGDTGALPFTPPMSFVDQLQVAEADVKAGRIKSFKTVDAL
MKDLYSDVDD
Download Length: 273 bp
>AT143788 NZ_CP061367:4441700-4442074 [Shigella sonnei]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7X2J6C9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A508YYT1 |