Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 835055..836148 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GG844_RS03800 Protein ID WP_000351248.1
Coordinates 835055..835456 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GG844_RS03805 Protein ID WP_001047169.1
Coordinates 835456..836148 (-) Length 231 a.a.

Genomic Context

GG844_RS03755GG844_RS03760GG844_RS03815GG844_RS03770GG844_RS03775GG844_RS03780GG844_RS03785GG844_RS03790GG844_RS03795GG844_RS03800GG844_RS03805GG844_RS03810GG844_RS03820GG844_RS03825GG844_RS03830GG844_RS03835GG844_RS03845GG844_RS19655GG844_RS03850GG844_RS03855
Location: 830193..831941 (1749 bp)
Type: Others
Protein ID: WP_000063386.1
Location: 832154..832399 (246 bp)
Type: Others
Protein ID: WP_001912198.1
Location: 836659..837639 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 832655..832807 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 833129..833584 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 833712..833999 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 833989..834240 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 834454..834867 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 834942..835085 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 835055..835456 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 835456..836148 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 836319..836591 (273 bp)
Type: Others
Protein ID: Protein_739
Location: 837764..837919 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 838087..838521 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 838658..838972 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 838959..839291 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 839632..839859 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 839808..839922 (115 bp)
Type: Others
Protein ID: Protein_746
Location: 840039..840210 (172 bp)
Type: Others
Protein ID: Protein_747
Location: 840528..840797 (270 bp)
Type: Others
Protein ID: WP_001198131.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GG844_RS03755830193..831941+1749WP_000063386.1hypothetical protein-
GG844_RS03760832154..832399+246WP_001912198.1hypothetical protein-
GG844_RS03770832655..832807-153WP_001884520.1DUF645 family protein-
GG844_RS03775833129..833584-456WP_001245327.1GNAT family N-acetyltransferase-
GG844_RS03780833712..833999-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GG844_RS03785833989..834240-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GG844_RS03790834454..834867-414WP_000049417.1VOC family protein-
GG844_RS03795834942..835085-144WP_071908341.1DUF3265 domain-containing protein-
GG844_RS03800835055..835456-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
GG844_RS03805835456..836148-693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
GG844_RS03810836319..836591-273Protein_739CatB-related O-acetyltransferase-
GG844_RS03815836659..837639+981WP_000019370.1IS5-like element ISVch5 family transposase-
GG844_RS03820837764..837919-156WP_000751734.1hypothetical protein-
GG844_RS03825838087..838521-435WP_000256036.1GNAT family N-acetyltransferase-
GG844_RS03830838658..838972-315WP_000071008.1DNA-binding transcriptional regulator-
GG844_RS03835838959..839291-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
GG844_RS03845839632..839859-228WP_001894457.1DUF1289 domain-containing protein-
GG844_RS19655839808..839922-115Protein_746acetyltransferase-
GG844_RS03850840039..840210-172Protein_747DUF645 family protein-
GG844_RS03855840528..840797-270WP_001198131.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron--833007..91452381516
flankIS/Tn--836659..837639980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T142374 WP_000351248.1 NZ_CP045718:c835456-835055 [Vibrio cholerae O395]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T142374 NZ_CP060672:c4050150-4049737 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT142374 WP_001047169.1 NZ_CP045718:c836148-835456 [Vibrio cholerae O395]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT142374 NZ_CP060672:c4050397-4050131 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References