Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 833712..834240 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag GG844_RS03780 Protein ID WP_000221354.1
Coordinates 833712..833999 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag GG844_RS03785 Protein ID WP_001250179.1
Coordinates 833989..834240 (-) Length 84 a.a.

Genomic Context

GG844_RS03745GG844_RS03750GG844_RS03755GG844_RS03760GG844_RS03815GG844_RS03770GG844_RS03775GG844_RS03780GG844_RS03785GG844_RS03790GG844_RS03795GG844_RS03800GG844_RS03805GG844_RS03810GG844_RS03820GG844_RS03825GG844_RS03830
Location: 829213..829557 (345 bp)
Type: Others
Protein ID: WP_001912196.1
Location: 829861..830196 (336 bp)
Type: Others
Protein ID: WP_000978438.1
Location: 830193..831941 (1749 bp)
Type: Others
Protein ID: WP_000063386.1
Location: 832154..832399 (246 bp)
Type: Others
Protein ID: WP_001912198.1
Location: 836659..837639 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 832655..832807 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 833129..833584 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 833712..833999 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 833989..834240 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 834454..834867 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 834942..835085 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 835055..835456 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 835456..836148 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 836319..836591 (273 bp)
Type: Others
Protein ID: Protein_739
Location: 837764..837919 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 838087..838521 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 838658..838972 (315 bp)
Type: Others
Protein ID: WP_000071008.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GG844_RS03745829213..829557+345WP_001912196.1hypothetical protein-
GG844_RS03750829861..830196+336WP_000978438.1hypothetical protein-
GG844_RS03755830193..831941+1749WP_000063386.1hypothetical protein-
GG844_RS03760832154..832399+246WP_001912198.1hypothetical protein-
GG844_RS03770832655..832807-153WP_001884520.1DUF645 family protein-
GG844_RS03775833129..833584-456WP_001245327.1GNAT family N-acetyltransferase-
GG844_RS03780833712..833999-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GG844_RS03785833989..834240-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GG844_RS03790834454..834867-414WP_000049417.1VOC family protein-
GG844_RS03795834942..835085-144WP_071908341.1DUF3265 domain-containing protein-
GG844_RS03800835055..835456-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GG844_RS03805835456..836148-693WP_001047169.1GNAT family N-acetyltransferase-
GG844_RS03810836319..836591-273Protein_739CatB-related O-acetyltransferase-
GG844_RS03815836659..837639+981WP_000019370.1IS5-like element ISVch5 family transposase-
GG844_RS03820837764..837919-156WP_000751734.1hypothetical protein-
GG844_RS03825838087..838521-435WP_000256036.1GNAT family N-acetyltransferase-
GG844_RS03830838658..838972-315WP_000071008.1DNA-binding transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegron--833007..91452381516
flankIS/Tn--836659..837639980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T142373 WP_000221354.1 NZ_CP045718:c833999-833712 [Vibrio cholerae O395]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T142373 NZ_CP060672:c4039246-4038848 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT142373 WP_001250179.1 NZ_CP045718:c834240-833989 [Vibrio cholerae O395]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT142373 NZ_CP060672:c4039473-4039246 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References