Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 833712..834240 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag GG844_RS03780 Protein ID WP_000221354.1
Coordinates 833712..833999 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag GG844_RS03785 Protein ID WP_001250179.1
Coordinates 833989..834240 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GG844_RS03745 829213..829557 + 345 WP_001912196.1 hypothetical protein -
GG844_RS03750 829861..830196 + 336 WP_000978438.1 hypothetical protein -
GG844_RS03755 830193..831941 + 1749 WP_000063386.1 hypothetical protein -
GG844_RS03760 832154..832399 + 246 WP_001912198.1 hypothetical protein -
GG844_RS03770 832655..832807 - 153 WP_001884520.1 DUF645 family protein -
GG844_RS03775 833129..833584 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
GG844_RS03780 833712..833999 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GG844_RS03785 833989..834240 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GG844_RS03790 834454..834867 - 414 WP_000049417.1 VOC family protein -
GG844_RS03795 834942..835085 - 144 WP_071908341.1 DUF3265 domain-containing protein -
GG844_RS03800 835055..835456 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GG844_RS03805 835456..836148 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
GG844_RS03810 836319..836591 - 273 Protein_739 CatB-related O-acetyltransferase -
GG844_RS03815 836659..837639 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GG844_RS03820 837764..837919 - 156 WP_000751734.1 hypothetical protein -
GG844_RS03825 838087..838521 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
GG844_RS03830 838658..838972 - 315 WP_000071008.1 DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 833007..914523 81516
flank IS/Tn - - 836659..837639 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T142373 WP_000221354.1 NZ_CP045718:c833999-833712 [Vibrio cholerae O395]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T142373 NZ_CP060672:c4039246-4038848 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT142373 WP_001250179.1 NZ_CP045718:c834240-833989 [Vibrio cholerae O395]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT142373 NZ_CP060672:c4039473-4039246 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References