Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 833712..834240 | Replicon | chromosome |
Accession | NZ_CP045718 | ||
Organism | Vibrio cholerae O395 substr. TCP2 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0X1KZS6 |
Locus tag | GG844_RS03780 | Protein ID | WP_000221354.1 |
Coordinates | 833712..833999 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0X1KZS8 |
Locus tag | GG844_RS03785 | Protein ID | WP_001250179.1 |
Coordinates | 833989..834240 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GG844_RS03745 | 829213..829557 | + | 345 | WP_001912196.1 | hypothetical protein | - |
GG844_RS03750 | 829861..830196 | + | 336 | WP_000978438.1 | hypothetical protein | - |
GG844_RS03755 | 830193..831941 | + | 1749 | WP_000063386.1 | hypothetical protein | - |
GG844_RS03760 | 832154..832399 | + | 246 | WP_001912198.1 | hypothetical protein | - |
GG844_RS03770 | 832655..832807 | - | 153 | WP_001884520.1 | DUF645 family protein | - |
GG844_RS03775 | 833129..833584 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
GG844_RS03780 | 833712..833999 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GG844_RS03785 | 833989..834240 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
GG844_RS03790 | 834454..834867 | - | 414 | WP_000049417.1 | VOC family protein | - |
GG844_RS03795 | 834942..835085 | - | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
GG844_RS03800 | 835055..835456 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
GG844_RS03805 | 835456..836148 | - | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
GG844_RS03810 | 836319..836591 | - | 273 | Protein_739 | CatB-related O-acetyltransferase | - |
GG844_RS03815 | 836659..837639 | + | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
GG844_RS03820 | 837764..837919 | - | 156 | WP_000751734.1 | hypothetical protein | - |
GG844_RS03825 | 838087..838521 | - | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
GG844_RS03830 | 838658..838972 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integron | - | - | 833007..914523 | 81516 | |
flank | IS/Tn | - | - | 836659..837639 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10991.96 Da Isoelectric Point: 10.4934
>T142373 WP_000221354.1 NZ_CP045718:c833999-833712 [Vibrio cholerae O395]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
Download Length: 288 bp
>T142373 NZ_CP060672:c4039246-4038848 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9136.29 Da Isoelectric Point: 4.0197
>AT142373 WP_001250179.1 NZ_CP045718:c834240-833989 [Vibrio cholerae O395]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL
Download Length: 252 bp
>AT142373 NZ_CP060672:c4039473-4039246 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0X1KZS6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0X1KZS8 |