142371

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 809837..810792 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag GG844_RS03620 Protein ID WP_000118351.1
Coordinates 809837..810370 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GG844_RS19640 Protein ID WP_001882332.1
Coordinates 810367..810792 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GG844_RS03575 805740..805958 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
GG844_RS03580 806022..806459 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
GG844_RS03585 806578..806787 - 210 Protein_694 GNAT family N-acetyltransferase -
GG844_RS03590 806923..807312 - 390 WP_001081302.1 hypothetical protein -
GG844_RS03595 807487..807729 - 243 WP_000107462.1 hypothetical protein -
GG844_RS03600 807937..808854 - 918 WP_000186333.1 alpha/beta hydrolase -
GG844_RS03605 809088..809390 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
GG844_RS03610 809378..809635 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GG844_RS03620 809837..810370 - 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
GG844_RS19640 810367..810792 - 426 WP_001882332.1 DUF1778 domain-containing protein Antitoxin
GG844_RS03630 810859..811230 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GG844_RS03635 811371..811658 - 288 WP_000426470.1 hypothetical protein -
GG844_RS03640 811810..812478 - 669 WP_000043871.1 hypothetical protein -
GG844_RS03645 812709..812981 + 273 WP_000246253.1 DUF1778 domain-containing protein -
GG844_RS03650 812978..813475 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
GG844_RS03655 813772..814266 + 495 WP_000477435.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 791552..816242 24690
- inside Integron - - 799407..812981 13574
flank IS/Tn - - 806022..806459 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T142371 WP_000118351.1 NZ_CP045718:c810370-809837 [Vibrio cholerae O395]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T142371 NZ_CP060672:2431314-2431469 [Salmonella enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT142371 WP_001882332.1 NZ_CP045718:c810792-810367 [Vibrio cholerae O395]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT142371 NZ_CP060672:c2431302-2431244 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM94

Antitoxin

Source ID Structure

References