Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 809837..810792 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag GG844_RS03620 Protein ID WP_000118351.1
Coordinates 809837..810370 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GG844_RS19640 Protein ID WP_001882332.1
Coordinates 810367..810792 (-) Length 142 a.a.

Genomic Context

GG844_RS03645GG844_RS03650GG844_RS03655GG844_RS03575GG844_RS03580GG844_RS03585GG844_RS03590GG844_RS03595GG844_RS03600GG844_RS03605GG844_RS03610GG844_RS03620GG844_RS19640GG844_RS03630GG844_RS03635GG844_RS03640
Location: 812709..812981 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 812978..813475 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 813772..814266 (495 bp)
Type: Others
Protein ID: WP_000477435.1
Location: 805740..805958 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 806022..806459 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 806578..806787 (210 bp)
Type: Others
Protein ID: Protein_694
Location: 806923..807312 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 807487..807729 (243 bp)
Type: Others
Protein ID: WP_000107462.1
Location: 807937..808854 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 809088..809390 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 809378..809635 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 809837..810370 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 810367..810792 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 810859..811230 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 811371..811658 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 811810..812478 (669 bp)
Type: Others
Protein ID: WP_000043871.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GG844_RS03575805740..805958-219WP_071908318.1GNAT family N-acetyltransferase-
GG844_RS03580806022..806459-438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
GG844_RS03585806578..806787-210Protein_694GNAT family N-acetyltransferase-
GG844_RS03590806923..807312-390WP_001081302.1hypothetical protein-
GG844_RS03595807487..807729-243WP_000107462.1hypothetical protein-
GG844_RS03600807937..808854-918WP_000186333.1alpha/beta hydrolase-
GG844_RS03605809088..809390-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
GG844_RS03610809378..809635-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GG844_RS03620809837..810370-534WP_000118351.1GNAT family N-acetyltransferaseToxin
GG844_RS19640810367..810792-426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
GG844_RS03630810859..811230-372WP_001164080.1nucleotide pyrophosphohydrolase-
GG844_RS03635811371..811658-288WP_000426470.1hypothetical protein-
GG844_RS03640811810..812478-669WP_000043871.1hypothetical protein-
GG844_RS03645812709..812981+273WP_000246253.1DUF1778 domain-containing protein-
GG844_RS03650812978..813475+498WP_000982260.1GNAT family N-acetyltransferase-
GG844_RS03655813772..814266+495WP_000477435.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--791552..81624224690
-insideIntegron--799407..81298113574
flankIS/Tn--806022..806459437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T142371 WP_000118351.1 NZ_CP045718:c810370-809837 [Vibrio cholerae O395]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T142371 NZ_CP060672:2431314-2431469 [Salmonella enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT142371 WP_001882332.1 NZ_CP045718:c810792-810367 [Vibrio cholerae O395]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT142371 NZ_CP060672:c2431302-2431244 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References