142368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 802968..803752 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GG844_RS03555 Protein ID WP_001114075.1
Coordinates 803483..803752 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag GG844_RS03550 Protein ID WP_000921691.1
Coordinates 802968..803489 (-) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GG844_RS03515 799894..800307 - 414 WP_000049420.1 VOC family protein -
GG844_RS03520 800491..801006 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
GG844_RS03525 801200..801484 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GG844_RS03530 801481..801759 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GG844_RS03535 801898..802293 - 396 WP_001000867.1 hypothetical protein -
GG844_RS03545 802544..802669 - 126 WP_001905700.1 DUF645 family protein -
GG844_RS03550 802968..803489 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
GG844_RS03555 803483..803752 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
GG844_RS03560 803783..803887 - 105 WP_099607150.1 acetyltransferase -
GG844_RS03565 803944..804543 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GG844_RS03570 804693..805565 - 873 WP_000254716.1 DUF3800 domain-containing protein -
GG844_RS03575 805740..805958 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
GG844_RS03580 806022..806459 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
GG844_RS03585 806578..806787 - 210 Protein_694 GNAT family N-acetyltransferase -
GG844_RS03590 806923..807312 - 390 WP_001081302.1 hypothetical protein -
GG844_RS03595 807487..807729 - 243 WP_000107462.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 791552..816242 24690
- inside Integron - - 799407..812981 13574
flank IS/Tn - - 806022..806459 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T142368 WP_001114075.1 NZ_CP045718:c803752-803483 [Vibrio cholerae O395]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T142368 NZ_CP060672:c1272203-1271946 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT142368 WP_000921691.1 NZ_CP045718:c803489-802968 [Vibrio cholerae O395]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT142368 NZ_CP060672:1272028-1272360 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References