Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 801200..801759 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GG844_RS03530 Protein ID WP_000578476.1
Coordinates 801481..801759 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GG844_RS03525 Protein ID WP_000381183.1
Coordinates 801200..801484 (+) Length 95 a.a.

Genomic Context

GG844_RS03485GG844_RS03490GG844_RS03495GG844_RS03525GG844_RS03530GG844_RS03515GG844_RS03520GG844_RS03535GG844_RS03545GG844_RS03550GG844_RS03555GG844_RS03560GG844_RS03565GG844_RS03570GG844_RS03575GG844_RS03580
Location: 796331..796738 (408 bp)
Type: Others
Protein ID: WP_000022491.1
Location: 796855..797799 (945 bp)
Type: Others
Protein ID: WP_001027829.1
Location: 797813..798082 (270 bp)
Type: Others
Protein ID: WP_000402869.1
Location: 801200..801484 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 801481..801759 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 799894..800307 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 800491..801006 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 801898..802293 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 802544..802669 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 802968..803489 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 803483..803752 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 803783..803887 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 803944..804543 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 804693..805565 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 805740..805958 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 806022..806459 (438 bp)
Type: Others
Protein ID: WP_000503164.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GG844_RS03485796331..796738+408WP_000022491.1hypothetical protein-
GG844_RS03490796855..797799+945WP_001027829.1hypothetical protein-
GG844_RS03495797813..798082+270WP_000402869.1hypothetical protein-
GG844_RS03515799894..800307-414WP_000049420.1VOC family protein-
GG844_RS03520800491..801006-516WP_000343779.1GNAT family N-acetyltransferase-
GG844_RS03525801200..801484+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GG844_RS03530801481..801759+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
GG844_RS03535801898..802293-396WP_001000867.1hypothetical protein-
GG844_RS03545802544..802669-126WP_001905700.1DUF645 family protein-
GG844_RS03550802968..803489-522WP_000921691.1DUF2442 domain-containing protein-
GG844_RS03555803483..803752-270WP_001114075.1DUF4160 domain-containing protein-
GG844_RS03560803783..803887-105WP_099607150.1acetyltransferase-
GG844_RS03565803944..804543-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GG844_RS03570804693..805565-873WP_000254716.1DUF3800 domain-containing protein-
GG844_RS03575805740..805958-219WP_071908318.1GNAT family N-acetyltransferase-
GG844_RS03580806022..806459-438WP_000503164.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--791552..81624224690
-insideIntegron--799407..81298113574
flankIS/Tn--806022..806459437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T142367 WP_000578476.1 NZ_CP045718:801481-801759 [Vibrio cholerae O395]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T142367 NZ_CP060672:886906-887193 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT142367 WP_000381183.1 NZ_CP045718:801200-801484 [Vibrio cholerae O395]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT142367 NZ_CP060672:887180-887482 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References