142367

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 801200..801759 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GG844_RS03530 Protein ID WP_000578476.1
Coordinates 801481..801759 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GG844_RS03525 Protein ID WP_000381183.1
Coordinates 801200..801484 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GG844_RS03485 796331..796738 + 408 WP_000022491.1 hypothetical protein -
GG844_RS03490 796855..797799 + 945 WP_001027829.1 hypothetical protein -
GG844_RS03495 797813..798082 + 270 WP_000402869.1 hypothetical protein -
GG844_RS03515 799894..800307 - 414 WP_000049420.1 VOC family protein -
GG844_RS03520 800491..801006 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
GG844_RS03525 801200..801484 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GG844_RS03530 801481..801759 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GG844_RS03535 801898..802293 - 396 WP_001000867.1 hypothetical protein -
GG844_RS03545 802544..802669 - 126 WP_001905700.1 DUF645 family protein -
GG844_RS03550 802968..803489 - 522 WP_000921691.1 DUF2442 domain-containing protein -
GG844_RS03555 803483..803752 - 270 WP_001114075.1 DUF4160 domain-containing protein -
GG844_RS03560 803783..803887 - 105 WP_099607150.1 acetyltransferase -
GG844_RS03565 803944..804543 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GG844_RS03570 804693..805565 - 873 WP_000254716.1 DUF3800 domain-containing protein -
GG844_RS03575 805740..805958 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
GG844_RS03580 806022..806459 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 791552..816242 24690
- inside Integron - - 799407..812981 13574
flank IS/Tn - - 806022..806459 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T142367 WP_000578476.1 NZ_CP045718:801481-801759 [Vibrio cholerae O395]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T142367 NZ_CP060672:886906-887193 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT142367 WP_000381183.1 NZ_CP045718:801200-801484 [Vibrio cholerae O395]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT142367 NZ_CP060672:887180-887482 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References