Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 1063089..1063667 Replicon chromosome
Accession NZ_CP043556
Organism Vibrio cholerae strain RFB16

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag F0316_RS19470 Protein ID WP_172626091.1
Coordinates 1063089..1063406 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A366AI09
Locus tag F0316_RS19475 Protein ID WP_000557291.1
Coordinates 1063425..1063667 (-) Length 81 a.a.

Genomic Context

F0316_RS19425F0316_RS19430F0316_RS19435F0316_RS19440F0316_RS19455F0316_RS19460F0316_RS19480F0316_RS19485F0316_RS19490F0316_RS19495F0316_RS19500F0316_RS19420F0316_RS19470F0316_RS19475F0316_RS19505
Location: 1059561..1060217 (657 bp)
Type: Others
Protein ID: WP_149560852.1
Location: 1060365..1061168 (804 bp)
Type: Others
Protein ID: WP_149560853.1
Location: 1061321..1061809 (489 bp)
Type: Others
Protein ID: WP_149560854.1
Location: 1061928..1062209 (282 bp)
Type: Others
Protein ID: WP_080368113.1
Location: 1062408..1062594 (187 bp)
Type: Others
Protein ID: Protein_989
Location: 1062591..1062824 (234 bp)
Type: Others
Protein ID: WP_148520751.1
Location: 1063911..1064258 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 1064547..1065671 (1125 bp)
Type: Others
Protein ID: WP_095474076.1
Location: 1065827..1066264 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 1066548..1067030 (483 bp)
Type: Others
Protein ID: WP_149560857.1
Location: 1067171..1067557 (387 bp)
Type: Others
Protein ID: WP_001015087.1
Location: 1058597..1059517 (921 bp)
Type: Others
Protein ID: WP_149560805.1
Location: 1063089..1063406 (318 bp)
Type: Toxin
Protein ID: WP_172626091.1
Location: 1063425..1063667 (243 bp)
Type: Antitoxin
Protein ID: WP_000557291.1
Location: 1067694..1067816 (123 bp)
Type: Others
Protein ID: Protein_998
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
F0316_RS194201058597..1059517-921WP_149560805.1IS5-like element ISVch8 family transposase-
F0316_RS194251059561..1060217+657WP_149560852.1LysE family translocator-
F0316_RS194301060365..1061168+804WP_149560853.1class I SAM-dependent methyltransferase-
F0316_RS194351061321..1061809+489WP_149560854.1hypothetical protein-
F0316_RS194401061928..1062209+282WP_080368113.1DUF1289 domain-containing protein-
F0316_RS194551062408..1062594+187Protein_989DUF3709 domain-containing protein-
F0316_RS194601062591..1062824+234WP_148520751.1DUF3709 domain-containing protein-
F0316_RS194701063089..1063406-318WP_172626091.1type II toxin-antitoxin system RelE/ParE family toxinToxin
F0316_RS194751063425..1063667-243WP_000557291.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
F0316_RS194801063911..1064258+348WP_000933409.1hypothetical protein-
F0316_RS194851064547..1065671+1125WP_095474076.1right-handed parallel beta-helix repeat-containing protein-
F0316_RS194901065827..1066264+438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
F0316_RS194951066548..1067030+483WP_149560857.1GNAT family N-acetyltransferase-
F0316_RS195001067171..1067557+387WP_001015087.1MmcQ/YjbR family DNA-binding protein-
F0316_RS195051067694..1067816-123Protein_998type II toxin-antitoxin system YafQ family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--1058597..1059517920
flankIS/Tn--1065827..1066264437
-insideIntegron--981561..107162390062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12201.01 Da        Isoelectric Point: 9.5425

>T139009 WP_172626091.1 NZ_CP043556:c1063406-1063089 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPELGKNCDDIYQNGFYFPVGKHMAYYTKEAG
FILIIAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T139009 NZ_CP058331:c704346-704065 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8931.22 Da        Isoelectric Point: 5.6630

>AT139009 WP_000557291.1 NZ_CP043556:c1063667-1063425 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL

Download         Length: 243 bp

>AT139009 NZ_CP043556:c1063667-1063425 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAGCGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCCATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCGCTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366AI09

References