139009

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 1063089..1063667 Replicon chromosome
Accession NZ_CP043556
Organism Vibrio cholerae strain RFB16

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag F0316_RS19470 Protein ID WP_172626091.1
Coordinates 1063089..1063406 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A366AI09
Locus tag F0316_RS19475 Protein ID WP_000557291.1
Coordinates 1063425..1063667 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0316_RS19420 1058597..1059517 - 921 WP_149560805.1 IS5-like element ISVch8 family transposase -
F0316_RS19425 1059561..1060217 + 657 WP_149560852.1 LysE family translocator -
F0316_RS19430 1060365..1061168 + 804 WP_149560853.1 class I SAM-dependent methyltransferase -
F0316_RS19435 1061321..1061809 + 489 WP_149560854.1 hypothetical protein -
F0316_RS19440 1061928..1062209 + 282 WP_080368113.1 DUF1289 domain-containing protein -
F0316_RS19455 1062408..1062594 + 187 Protein_989 DUF3709 domain-containing protein -
F0316_RS19460 1062591..1062824 + 234 WP_148520751.1 DUF3709 domain-containing protein -
F0316_RS19470 1063089..1063406 - 318 WP_172626091.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0316_RS19475 1063425..1063667 - 243 WP_000557291.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F0316_RS19480 1063911..1064258 + 348 WP_000933409.1 hypothetical protein -
F0316_RS19485 1064547..1065671 + 1125 WP_095474076.1 right-handed parallel beta-helix repeat-containing protein -
F0316_RS19490 1065827..1066264 + 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
F0316_RS19495 1066548..1067030 + 483 WP_149560857.1 GNAT family N-acetyltransferase -
F0316_RS19500 1067171..1067557 + 387 WP_001015087.1 MmcQ/YjbR family DNA-binding protein -
F0316_RS19505 1067694..1067816 - 123 Protein_998 type II toxin-antitoxin system YafQ family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1058597..1059517 920
flank IS/Tn - - 1065827..1066264 437
- inside Integron - - 981561..1071623 90062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12201.01 Da        Isoelectric Point: 9.5425

>T139009 WP_172626091.1 NZ_CP043556:c1063406-1063089 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPELGKNCDDIYQNGFYFPVGKHMAYYTKEAG
FILIIAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T139009 NZ_CP058331:c704346-704065 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8931.22 Da        Isoelectric Point: 5.6630

>AT139009 WP_000557291.1 NZ_CP043556:c1063667-1063425 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL

Download         Length: 243 bp

>AT139009 NZ_CP043556:c1063667-1063425 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAGCGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCCATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCGCTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A366AI09

References