Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 2445466..2445837 Replicon chromosome
Accession NZ_CP043199
Organism Escherichia coli O16:H48 strain PG20180060

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag FYA11_RS11915 Protein ID WP_001317028.1
Coordinates 2445643..2445837 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 2445466..2445644 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA11_RS11890 2441421..2442794 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
FYA11_RS11895 2442923..2443858 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
FYA11_RS11900 2443910..2445145 - 1236 WP_000040852.1 site-specific integrase -
FYA11_RS11905 2445147..2445362 - 216 WP_000079604.1 excisionase XisR -
FYA11_RS11910 2445441..2445650 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 2445466..2445644 + 179 NuclAT_0 - Antitoxin
- 2445466..2445644 + 179 NuclAT_0 - Antitoxin
- 2445466..2445644 + 179 NuclAT_0 - Antitoxin
- 2445466..2445644 + 179 NuclAT_0 - Antitoxin
FYA11_RS11915 2445643..2445837 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
FYA11_RS11920 2445894..2446703 - 810 WP_000166319.1 recombination protein RecT -
FYA11_RS11925 2446696..2449296 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
FYA11_RS11930 2449398..2449673 - 276 WP_000632297.1 protein RacC -
FYA11_RS11935 2449748..2449918 - 171 WP_001352098.1 conserved protein, Rac prophage -
FYA11_RS11940 2449918..2450139 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2443910..2465584 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T137666 WP_001317028.1 NZ_CP043199:c2445837-2445643 [Escherichia coli O16:H48]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T137666 NZ_CP056883:c5174597-5174214 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 179 bp

>AT137666 NZ_CP043199:2445466-2445644 [Escherichia coli O16:H48]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References