135199

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 846939..847467 Replicon chromosome
Accession NZ_CP042300
Organism Vibrio cholerae O1 strain AAS91

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag FKV26_RS17220 Protein ID WP_000221354.1
Coordinates 846939..847226 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag FKV26_RS17225 Protein ID WP_001250179.1
Coordinates 847216..847467 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKV26_RS17175 842286..842588 - 303 WP_000229325.1 type II toxin-antitoxin system RelE/ParE family toxin -
FKV26_RS17180 842576..842833 - 258 WP_070961997.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FKV26_RS17190 843306..844286 - 981 WP_000019368.1 IS5-like element ISVch5 family transposase -
FKV26_RS17195 844356..844682 - 327 Protein_745 hypothetical protein -
FKV26_RS17200 844913..845185 + 273 WP_000246253.1 DUF1778 domain-containing protein -
FKV26_RS17205 845182..845679 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
FKV26_RS17210 845882..846034 - 153 WP_001884520.1 DUF645 family protein -
FKV26_RS17215 846356..846811 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
FKV26_RS17220 846939..847226 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FKV26_RS17225 847216..847467 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FKV26_RS17230 847681..848094 - 414 WP_000049417.1 VOC family protein -
FKV26_RS17235 848169..848312 - 144 WP_071908341.1 DUF3265 domain-containing protein -
FKV26_RS17240 848282..848683 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
FKV26_RS17245 848683..849375 - 693 WP_001047169.1 GNAT family N-acetyltransferase -
FKV26_RS17250 849512..849818 - 307 Protein_756 CatB-related O-acetyltransferase -
FKV26_RS17255 849886..850866 + 981 WP_000019368.1 IS5-like element ISVch5 family transposase -
FKV26_RS18965 850991..851191 - 201 WP_001198130.1 hypothetical protein -
FKV26_RS17260 851551..851724 - 174 WP_001882305.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 827249..947639 120390
flank IS/Tn - - 843306..844286 980
flank IS/Tn - - 849886..850866 980
- inside Integron - - 828494..941258 112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T135199 WP_000221354.1 NZ_CP042300:c847226-846939 [Vibrio cholerae O1]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T135199 NZ_CP042300:c847226-846939 [Vibrio cholerae O1]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT135199 WP_001250179.1 NZ_CP042300:c847467-847216 [Vibrio cholerae O1]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT135199 NZ_CP042300:c847467-847216 [Vibrio cholerae O1]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References