Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 846939..847467 Replicon chromosome
Accession NZ_CP042300
Organism Vibrio cholerae O1 strain AAS91

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag FKV26_RS17220 Protein ID WP_000221354.1
Coordinates 846939..847226 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag FKV26_RS17225 Protein ID WP_001250179.1
Coordinates 847216..847467 (-) Length 84 a.a.

Genomic Context

FKV26_RS17200FKV26_RS17205FKV26_RS17255FKV26_RS17175FKV26_RS17180FKV26_RS17190FKV26_RS17195FKV26_RS17210FKV26_RS17215FKV26_RS17220FKV26_RS17225FKV26_RS17230FKV26_RS17235FKV26_RS17240FKV26_RS17245FKV26_RS17250FKV26_RS18965FKV26_RS17260
Location: 844913..845185 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 845182..845679 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 849886..850866 (981 bp)
Type: Others
Protein ID: WP_000019368.1
Location: 842286..842588 (303 bp)
Type: Others
Protein ID: WP_000229325.1
Location: 842576..842833 (258 bp)
Type: Others
Protein ID: WP_070961997.1
Location: 843306..844286 (981 bp)
Type: Others
Protein ID: WP_000019368.1
Location: 844356..844682 (327 bp)
Type: Others
Protein ID: Protein_745
Location: 845882..846034 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 846356..846811 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 846939..847226 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 847216..847467 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 847681..848094 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 848169..848312 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 848282..848683 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 848683..849375 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 849512..849818 (307 bp)
Type: Others
Protein ID: Protein_756
Location: 850991..851191 (201 bp)
Type: Others
Protein ID: WP_001198130.1
Location: 851551..851724 (174 bp)
Type: Others
Protein ID: WP_001882305.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FKV26_RS17175842286..842588-303WP_000229325.1type II toxin-antitoxin system RelE/ParE family toxin-
FKV26_RS17180842576..842833-258WP_070961997.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FKV26_RS17190843306..844286-981WP_000019368.1IS5-like element ISVch5 family transposase-
FKV26_RS17195844356..844682-327Protein_745hypothetical protein-
FKV26_RS17200844913..845185+273WP_000246253.1DUF1778 domain-containing protein-
FKV26_RS17205845182..845679+498WP_000982260.1GNAT family N-acetyltransferase-
FKV26_RS17210845882..846034-153WP_001884520.1DUF645 family protein-
FKV26_RS17215846356..846811-456WP_001245327.1GNAT family N-acetyltransferase-
FKV26_RS17220846939..847226-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FKV26_RS17225847216..847467-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
FKV26_RS17230847681..848094-414WP_000049417.1VOC family protein-
FKV26_RS17235848169..848312-144WP_071908341.1DUF3265 domain-containing protein-
FKV26_RS17240848282..848683-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
FKV26_RS17245848683..849375-693WP_001047169.1GNAT family N-acetyltransferase-
FKV26_RS17250849512..849818-307Protein_756CatB-related O-acetyltransferase-
FKV26_RS17255849886..850866+981WP_000019368.1IS5-like element ISVch5 family transposase-
FKV26_RS18965850991..851191-201WP_001198130.1hypothetical protein-
FKV26_RS17260851551..851724-174WP_001882305.1DUF3709 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-827249..947639120390
flankIS/Tn--843306..844286980
flankIS/Tn--849886..850866980
-insideIntegron--828494..941258112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T135199 WP_000221354.1 NZ_CP042300:c847226-846939 [Vibrio cholerae O1]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T135199 NZ_CP042300:c847226-846939 [Vibrio cholerae O1]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT135199 WP_001250179.1 NZ_CP042300:c847467-847216 [Vibrio cholerae O1]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT135199 NZ_CP042300:c847467-847216 [Vibrio cholerae O1]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References