Detailed information of TA system TA135198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 844913..845679
• Replicon: chromosome
• Accession: NZ_CP042300
• Organism: Vibrio cholerae O1 strain AAS91

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9K2P7
• Locus tag: FKV26_RS17205
• Protein ID: WP_000982260.1
• Coordinates: 845182..845679 (+)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9K2J6
• Locus tag: FKV26_RS17200
• Protein ID: WP_000246253.1
• Coordinates: 844913..845185 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FKV26_RS17150	839946..840317	-	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
FKV26_RS17155	840565..840825	-	261	WP_032468027.1	DUF3709 domain-containing protein	-
FKV26_RS17160	840843..841003	-	161	Protein_739	DUF3709 domain-containing protein	-
FKV26_RS17165	841237..841461	-	225	WP_161571222.1	DUF3709 domain-containing protein	-
FKV26_RS17170	841791..841901	-	111	WP_076025930.1	DUF645 family protein	-
FKV26_RS17175	842286..842588	-	303	WP_000229325.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FKV26_RS17180	842576..842833	-	258	WP_070961997.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FKV26_RS17190	843306..844286	-	981	WP_000019368.1	IS5-like element ISVch5 family transposase	-
FKV26_RS17195	844356..844682	-	327	Protein_745	hypothetical protein	-
FKV26_RS17200	844913..845185	+	273	WP_000246253.1	DUF1778 domain-containing protein	Antitoxin
FKV26_RS17205	845182..845679	+	498	WP_000982260.1	GNAT family N-acetyltransferase	Toxin
FKV26_RS17210	845882..846034	-	153	WP_001884520.1	DUF645 family protein	-
FKV26_RS17215	846356..846811	-	456	WP_001245327.1	GNAT family N-acetyltransferase	-
FKV26_RS17220	846939..847226	-	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FKV26_RS17225	847216..847467	-	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FKV26_RS17230	847681..848094	-	414	WP_000049417.1	VOC family protein	-
FKV26_RS17235	848169..848312	-	144	WP_071908341.1	DUF3265 domain-containing protein	-
FKV26_RS17240	848282..848683	-	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	-
FKV26_RS17245	848683..849375	-	693	WP_001047169.1	GNAT family N-acetyltransferase	-
FKV26_RS17250	849512..849818	-	307	Protein_756	CatB-related O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	827249..947639	120390
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000174, TA000175, TA000176, TA010030 416601..417581 0.001	flank	IS/Tn	-	-	843306..844286	980
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000174, TA000175, TA000176, TA010030 416601..417581 0.001	flank	IS/Tn	-	-	849886..850866	980
	-	inside	Integron	-	-	828494..941258	112764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-86)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18527.18 Da
• Isoelectric Point: 8.7753

>T135198 WP_000982260.1 NZ_CP042300:845182-845679 [Vibrio cholerae O1]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Nucleotide

• Length: 498 bp

>T135198 NZ_CP042300:845182-845679 [Vibrio cholerae O1]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9683.22 Da
• Isoelectric Point: 6.2988

>AT135198 WP_000246253.1 NZ_CP042300:844913-845185 [Vibrio cholerae O1]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Nucleotide

• Length: 273 bp

>AT135198 NZ_CP042300:844913-845185 [Vibrio cholerae O1]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Structures

Toxin

• AlphaFold DB: A0A0Q0KGB1

Antitoxin

• AlphaFold DB: A0A0F2IC79