Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 844913..845679 Replicon chromosome
Accession NZ_CP042300
Organism Vibrio cholerae O1 strain AAS91

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag FKV26_RS17205 Protein ID WP_000982260.1
Coordinates 845182..845679 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag FKV26_RS17200 Protein ID WP_000246253.1
Coordinates 844913..845185 (+) Length 91 a.a.

Genomic Context

FKV26_RS17200FKV26_RS17205FKV26_RS17150FKV26_RS17155FKV26_RS17160FKV26_RS17165FKV26_RS17170FKV26_RS17175FKV26_RS17180FKV26_RS17190FKV26_RS17195FKV26_RS17210FKV26_RS17215FKV26_RS17220FKV26_RS17225FKV26_RS17230FKV26_RS17235FKV26_RS17240FKV26_RS17245FKV26_RS17250
Location: 844913..845185 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 845182..845679 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 839946..840317 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 840565..840825 (261 bp)
Type: Others
Protein ID: WP_032468027.1
Location: 840843..841003 (161 bp)
Type: Others
Protein ID: Protein_739
Location: 841237..841461 (225 bp)
Type: Others
Protein ID: WP_161571222.1
Location: 841791..841901 (111 bp)
Type: Others
Protein ID: WP_076025930.1
Location: 842286..842588 (303 bp)
Type: Others
Protein ID: WP_000229325.1
Location: 842576..842833 (258 bp)
Type: Others
Protein ID: WP_070961997.1
Location: 843306..844286 (981 bp)
Type: Others
Protein ID: WP_000019368.1
Location: 844356..844682 (327 bp)
Type: Others
Protein ID: Protein_745
Location: 845882..846034 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 846356..846811 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 846939..847226 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 847216..847467 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 847681..848094 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 848169..848312 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 848282..848683 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 848683..849375 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 849512..849818 (307 bp)
Type: Others
Protein ID: Protein_756
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FKV26_RS17150839946..840317-372WP_001164080.1nucleotide pyrophosphohydrolase-
FKV26_RS17155840565..840825-261WP_032468027.1DUF3709 domain-containing protein-
FKV26_RS17160840843..841003-161Protein_739DUF3709 domain-containing protein-
FKV26_RS17165841237..841461-225WP_161571222.1DUF3709 domain-containing protein-
FKV26_RS17170841791..841901-111WP_076025930.1DUF645 family protein-
FKV26_RS17175842286..842588-303WP_000229325.1type II toxin-antitoxin system RelE/ParE family toxin-
FKV26_RS17180842576..842833-258WP_070961997.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FKV26_RS17190843306..844286-981WP_000019368.1IS5-like element ISVch5 family transposase-
FKV26_RS17195844356..844682-327Protein_745hypothetical protein-
FKV26_RS17200844913..845185+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
FKV26_RS17205845182..845679+498WP_000982260.1GNAT family N-acetyltransferaseToxin
FKV26_RS17210845882..846034-153WP_001884520.1DUF645 family protein-
FKV26_RS17215846356..846811-456WP_001245327.1GNAT family N-acetyltransferase-
FKV26_RS17220846939..847226-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
FKV26_RS17225847216..847467-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FKV26_RS17230847681..848094-414WP_000049417.1VOC family protein-
FKV26_RS17235848169..848312-144WP_071908341.1DUF3265 domain-containing protein-
FKV26_RS17240848282..848683-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
FKV26_RS17245848683..849375-693WP_001047169.1GNAT family N-acetyltransferase-
FKV26_RS17250849512..849818-307Protein_756CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-827249..947639120390
flankIS/Tn--843306..844286980
flankIS/Tn--849886..850866980
-insideIntegron--828494..941258112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T135198 WP_000982260.1 NZ_CP042300:845182-845679 [Vibrio cholerae O1]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T135198 NZ_CP042300:845182-845679 [Vibrio cholerae O1]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT135198 WP_000246253.1 NZ_CP042300:844913-845185 [Vibrio cholerae O1]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT135198 NZ_CP042300:844913-845185 [Vibrio cholerae O1]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References