Detailed information of TA system TA135197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 842286..842833
• Replicon: chromosome
• Accession: NZ_CP042300
• Organism: Vibrio cholerae O1 strain AAS91

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FKV26_RS17175
• Protein ID: WP_000229325.1
• Coordinates: 842286..842588 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FKV26_RS17180
• Protein ID: WP_070961997.1
• Coordinates: 842576..842833 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FKV26_RS17125	838175..838477	-	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FKV26_RS17130	838465..838722	-	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FKV26_RS17140	838924..839457	-	534	WP_000118351.1	GNAT family N-acetyltransferase	-
FKV26_RS17145	839454..839879	-	426	WP_001882332.1	DUF1778 domain-containing protein	-
FKV26_RS17150	839946..840317	-	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
FKV26_RS17155	840565..840825	-	261	WP_032468027.1	DUF3709 domain-containing protein	-
FKV26_RS17160	840843..841003	-	161	Protein_739	DUF3709 domain-containing protein	-
FKV26_RS17165	841237..841461	-	225	WP_161571222.1	DUF3709 domain-containing protein	-
FKV26_RS17170	841791..841901	-	111	WP_076025930.1	DUF645 family protein	-
FKV26_RS17175	842286..842588	-	303	WP_000229325.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FKV26_RS17180	842576..842833	-	258	WP_070961997.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FKV26_RS17190	843306..844286	-	981	WP_000019368.1	IS5-like element ISVch5 family transposase	-
FKV26_RS17195	844356..844682	-	327	Protein_745	hypothetical protein	-
FKV26_RS17200	844913..845185	+	273	WP_000246253.1	DUF1778 domain-containing protein	-
FKV26_RS17205	845182..845679	+	498	WP_000982260.1	GNAT family N-acetyltransferase	-
FKV26_RS17210	845882..846034	-	153	WP_001884520.1	DUF645 family protein	-
FKV26_RS17215	846356..846811	-	456	WP_001245327.1	GNAT family N-acetyltransferase	-
FKV26_RS17220	846939..847226	-	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FKV26_RS17225	847216..847467	-	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	827249..947639	120390
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000174, TA000175, TA000176, TA010030 416601..417581 0.001	flank	IS/Tn	-	-	843306..844286	980
	-	inside	Integron	-	-	828494..941258	112764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11710.64 Da
• Isoelectric Point: 5.1972

>T135197 WP_000229325.1 NZ_CP042300:c842588-842286 [Vibrio cholerae O1]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T135197 NZ_CP042300:c842588-842286 [Vibrio cholerae O1]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCTCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9629.12 Da
• Isoelectric Point: 7.3178

>AT135197 WP_070961997.1 NZ_CP042300:c842833-842576 [Vibrio cholerae O1]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRI
SKWLK

Nucleotide

• Length: 258 bp

>AT135197 NZ_CP042300:c842833-842576 [Vibrio cholerae O1]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCTTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATA
TCAAAATGGTTGAAATAA