Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 832570..832974 Replicon chromosome
Accession NZ_CP042300
Organism Vibrio cholerae O1 strain AAS91

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag FKV26_RS17075 Protein ID WP_001114075.1
Coordinates 832570..832839 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag FKV26_RS17080 Protein ID WP_099607150.1
Coordinates 832870..832974 (-) Length 35 a.a.

Genomic Context

FKV26_RS17050FKV26_RS17055FKV26_RS17040FKV26_RS17045FKV26_RS17060FKV26_RS17065FKV26_RS17070FKV26_RS17075FKV26_RS17080FKV26_RS17085FKV26_RS17090FKV26_RS17095FKV26_RS17100FKV26_RS17105FKV26_RS17110FKV26_RS17115FKV26_RS17120
Location: 830287..830571 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 830568..830846 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 828981..829394 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 829578..830093 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 830985..831380 (396 bp)
Type: Others
Protein ID: WP_001000868.1
Location: 831631..831756 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 832055..832576 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 832570..832839 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 832870..832974 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 833031..833630 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 833780..834652 (873 bp)
Type: Others
Protein ID: WP_000254717.1
Location: 834827..835045 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 835109..835546 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 835665..835874 (210 bp)
Type: Others
Protein ID: Protein_729
Location: 836010..836399 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 836574..836816 (243 bp)
Type: Others
Protein ID: WP_000107462.1
Location: 837024..837941 (918 bp)
Type: Others
Protein ID: WP_033935911.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FKV26_RS17040828981..829394-414WP_000049420.1VOC family protein-
FKV26_RS17045829578..830093-516WP_000343779.1GNAT family N-acetyltransferase-
FKV26_RS17050830287..830571+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
FKV26_RS17055830568..830846+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
FKV26_RS17060830985..831380-396WP_001000868.1hypothetical protein-
FKV26_RS17065831631..831756-126WP_001905700.1DUF645 family protein-
FKV26_RS17070832055..832576-522WP_000921691.1DUF2442 domain-containing protein-
FKV26_RS17075832570..832839-270WP_001114075.1DUF4160 domain-containing proteinToxin
FKV26_RS17080832870..832974-105WP_099607150.1acetyltransferaseAntitoxin
FKV26_RS17085833031..833630-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
FKV26_RS17090833780..834652-873WP_000254717.1DUF3800 domain-containing protein-
FKV26_RS17095834827..835045-219WP_071908318.1GNAT family N-acetyltransferase-
FKV26_RS17100835109..835546-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
FKV26_RS17105835665..835874-210Protein_729GNAT family N-acetyltransferase-
FKV26_RS17110836010..836399-390WP_001081302.1hypothetical protein-
FKV26_RS17115836574..836816-243WP_000107462.1hypothetical protein-
FKV26_RS17120837024..837941-918WP_033935911.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-827249..947639120390
flankIS/Tn--835109..835546437
-insideIntegron--828494..941258112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T135194 WP_001114075.1 NZ_CP042300:c832839-832570 [Vibrio cholerae O1]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T135194 NZ_CP042300:c832839-832570 [Vibrio cholerae O1]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT135194 WP_099607150.1 NZ_CP042300:c832974-832870 [Vibrio cholerae O1]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT135194 NZ_CP042300:c832974-832870 [Vibrio cholerae O1]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References