135192

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 830287..830846 Replicon chromosome
Accession NZ_CP042300
Organism Vibrio cholerae O1 strain AAS91

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag FKV26_RS17055 Protein ID WP_000578476.1
Coordinates 830568..830846 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag FKV26_RS17050 Protein ID WP_000381183.1
Coordinates 830287..830571 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKV26_RS17020 825498..826127 - 630 WP_001284008.1 DnaJ domain-containing protein -
FKV26_RS17025 826363..826950 + 588 WP_001131372.1 DUF2238 domain-containing protein -
FKV26_RS17040 828981..829394 - 414 WP_000049420.1 VOC family protein -
FKV26_RS17045 829578..830093 - 516 WP_000343779.1 GNAT family N-acetyltransferase -
FKV26_RS17050 830287..830571 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FKV26_RS17055 830568..830846 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FKV26_RS17060 830985..831380 - 396 WP_001000868.1 hypothetical protein -
FKV26_RS17065 831631..831756 - 126 WP_001905700.1 DUF645 family protein -
FKV26_RS17070 832055..832576 - 522 WP_000921691.1 DUF2442 domain-containing protein -
FKV26_RS17075 832570..832839 - 270 WP_001114075.1 DUF4160 domain-containing protein -
FKV26_RS17080 832870..832974 - 105 WP_099607150.1 acetyltransferase -
FKV26_RS17085 833031..833630 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
FKV26_RS17090 833780..834652 - 873 WP_000254717.1 DUF3800 domain-containing protein -
FKV26_RS17095 834827..835045 - 219 WP_071908318.1 GNAT family N-acetyltransferase -
FKV26_RS17100 835109..835546 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 827249..947639 120390
flank IS/Tn - - 835109..835546 437
- inside Integron - - 828494..941258 112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T135192 WP_000578476.1 NZ_CP042300:830568-830846 [Vibrio cholerae O1]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T135192 NZ_CP042300:830568-830846 [Vibrio cholerae O1]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT135192 WP_000381183.1 NZ_CP042300:830287-830571 [Vibrio cholerae O1]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT135192 NZ_CP042300:830287-830571 [Vibrio cholerae O1]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References