Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 830287..830846 Replicon chromosome
Accession NZ_CP042300
Organism Vibrio cholerae O1 strain AAS91

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag FKV26_RS17055 Protein ID WP_000578476.1
Coordinates 830568..830846 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag FKV26_RS17050 Protein ID WP_000381183.1
Coordinates 830287..830571 (+) Length 95 a.a.

Genomic Context

FKV26_RS17025FKV26_RS17050FKV26_RS17055FKV26_RS17020FKV26_RS17040FKV26_RS17045FKV26_RS17060FKV26_RS17065FKV26_RS17070FKV26_RS17075FKV26_RS17080FKV26_RS17085FKV26_RS17090FKV26_RS17095FKV26_RS17100
Location: 826363..826950 (588 bp)
Type: Others
Protein ID: WP_001131372.1
Location: 830287..830571 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 830568..830846 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 825498..826127 (630 bp)
Type: Others
Protein ID: WP_001284008.1
Location: 828981..829394 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 829578..830093 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 830985..831380 (396 bp)
Type: Others
Protein ID: WP_001000868.1
Location: 831631..831756 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 832055..832576 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 832570..832839 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 832870..832974 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 833031..833630 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 833780..834652 (873 bp)
Type: Others
Protein ID: WP_000254717.1
Location: 834827..835045 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 835109..835546 (438 bp)
Type: Others
Protein ID: WP_000503169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FKV26_RS17020825498..826127-630WP_001284008.1DnaJ domain-containing protein-
FKV26_RS17025826363..826950+588WP_001131372.1DUF2238 domain-containing protein-
FKV26_RS17040828981..829394-414WP_000049420.1VOC family protein-
FKV26_RS17045829578..830093-516WP_000343779.1GNAT family N-acetyltransferase-
FKV26_RS17050830287..830571+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
FKV26_RS17055830568..830846+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
FKV26_RS17060830985..831380-396WP_001000868.1hypothetical protein-
FKV26_RS17065831631..831756-126WP_001905700.1DUF645 family protein-
FKV26_RS17070832055..832576-522WP_000921691.1DUF2442 domain-containing protein-
FKV26_RS17075832570..832839-270WP_001114075.1DUF4160 domain-containing protein-
FKV26_RS17080832870..832974-105WP_099607150.1acetyltransferase-
FKV26_RS17085833031..833630-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
FKV26_RS17090833780..834652-873WP_000254717.1DUF3800 domain-containing protein-
FKV26_RS17095834827..835045-219WP_071908318.1GNAT family N-acetyltransferase-
FKV26_RS17100835109..835546-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-827249..947639120390
flankIS/Tn--835109..835546437
-insideIntegron--828494..941258112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T135192 WP_000578476.1 NZ_CP042300:830568-830846 [Vibrio cholerae O1]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T135192 NZ_CP042300:830568-830846 [Vibrio cholerae O1]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT135192 WP_000381183.1 NZ_CP042300:830287-830571 [Vibrio cholerae O1]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT135192 NZ_CP042300:830287-830571 [Vibrio cholerae O1]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References