Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1401434..1401805 Replicon chromosome
Accession NZ_CP040664
Organism Escherichia coli strain KR2009

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag FE384_RS06910 Protein ID WP_001317028.1
Coordinates 1401611..1401805 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1401434..1401612 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE384_RS06885 1397389..1398762 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
FE384_RS06890 1398891..1399826 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
FE384_RS06895 1399878..1401113 - 1236 WP_000040852.1 site-specific integrase -
FE384_RS06900 1401115..1401330 - 216 WP_000079604.1 excisionase XisR -
FE384_RS06905 1401409..1401618 - 210 WP_138817846.1 double-strand break reduction protein RcbA -
- 1401434..1401612 + 179 NuclAT_0 - Antitoxin
- 1401434..1401612 + 179 NuclAT_0 - Antitoxin
- 1401434..1401612 + 179 NuclAT_0 - Antitoxin
- 1401434..1401612 + 179 NuclAT_0 - Antitoxin
FE384_RS06910 1401611..1401805 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
FE384_RS06915 1401862..1402671 - 810 WP_000166319.1 recombination protein RecT -
FE384_RS06920 1402664..1405264 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
FE384_RS06925 1405366..1405640 - 275 Protein_1344 hypothetical protein -
FE384_RS06930 1405715..1405885 - 171 WP_001352098.1 conserved protein, Rac prophage -
FE384_RS06935 1405885..1406106 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1399878..1421551 21673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T126389 WP_001317028.1 NZ_CP040664:c1401805-1401611 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T126389 NZ_CP040664:c1401805-1401611 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT126389 NZ_CP040664:1401434-1401612 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References