Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1402473..1402844 Replicon chromosome
Accession NZ_CP040663
Organism Escherichia coli strain EK2009

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag FE383_RS06910 Protein ID WP_001317028.1
Coordinates 1402650..1402844 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1402473..1402651 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE383_RS06885 1398428..1399801 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
FE383_RS06890 1399930..1400865 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
FE383_RS06895 1400917..1402152 - 1236 WP_000040852.1 site-specific integrase -
FE383_RS06900 1402154..1402369 - 216 WP_000079604.1 excisionase XisR -
FE383_RS06905 1402448..1402657 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1402473..1402651 + 179 NuclAT_0 - Antitoxin
- 1402473..1402651 + 179 NuclAT_0 - Antitoxin
- 1402473..1402651 + 179 NuclAT_0 - Antitoxin
- 1402473..1402651 + 179 NuclAT_0 - Antitoxin
FE383_RS06910 1402650..1402844 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
FE383_RS06915 1402901..1403710 - 810 WP_000166319.1 recombination protein RecT -
FE383_RS06920 1403703..1406303 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
FE383_RS06925 1406405..1406680 - 276 WP_000632297.1 protein RacC -
FE383_RS06930 1406755..1406925 - 171 WP_001352098.1 conserved protein, Rac prophage -
FE383_RS06935 1406925..1407146 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1400917..1422591 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T126346 WP_001317028.1 NZ_CP040663:c1402844-1402650 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T126346 NZ_CP040663:c1402844-1402650 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT126346 NZ_CP040663:1402473-1402651 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References