Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1547520..1547891 Replicon chromosome
Accession NZ_CP040643
Organism Escherichia coli strain BE104

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag FGC38_RS07775 Protein ID WP_001317028.1
Coordinates 1547697..1547891 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1547520..1547698 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGC38_RS07750 1543475..1544848 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
FGC38_RS07755 1544977..1545912 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
FGC38_RS07760 1545964..1547199 - 1236 WP_000040852.1 site-specific integrase -
FGC38_RS07765 1547201..1547416 - 216 WP_000079604.1 excisionase XisR -
FGC38_RS07770 1547495..1547704 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1547520..1547698 + 179 NuclAT_0 - Antitoxin
- 1547520..1547698 + 179 NuclAT_0 - Antitoxin
- 1547520..1547698 + 179 NuclAT_0 - Antitoxin
- 1547520..1547698 + 179 NuclAT_0 - Antitoxin
FGC38_RS07775 1547697..1547891 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
FGC38_RS07780 1547948..1548757 - 810 WP_000166319.1 recombination protein RecT -
FGC38_RS07785 1548750..1551350 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
FGC38_RS07790 1551452..1551727 - 276 WP_000632297.1 protein RacC -
FGC38_RS07795 1551802..1551972 - 171 WP_001352098.1 conserved protein, Rac prophage -
FGC38_RS07800 1551972..1552193 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1545964..1567638 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T126259 WP_001317028.1 NZ_CP040643:c1547891-1547697 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T126259 NZ_CP040643:c1547891-1547697 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT126259 NZ_CP040643:1547520-1547698 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References