Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 443341..443869 Replicon chromosome
Accession NZ_CP037923
Organism Shigella flexneri 5a str. M90T

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EKN05_RS02315 Protein ID WP_005061113.1
Coordinates 443341..443571 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q32DW6
Locus tag EKN05_RS02320 Protein ID WP_000147081.1
Coordinates 443561..443869 (+) Length 103 a.a.

Genomic Context

EKN05_RS02315EKN05_RS02320EKN05_RS02280EKN05_RS02285EKN05_RS02290EKN05_RS02295EKN05_RS02300EKN05_RS02305EKN05_RS25530EKN05_RS25535EKN05_RS02325EKN05_RS02330EKN05_RS02335EKN05_RS02340EKN05_RS02345
Location: 443341..443571 (231 bp)
Type: Toxin
Protein ID: WP_005061113.1
Location: 443561..443869 (309 bp)
Type: Antitoxin
Protein ID: WP_000147081.1
Location: 438409..438609 (201 bp)
Type: Others
Protein ID: WP_000111769.1
Location: 438704..438961 (258 bp)
Type: Others
Protein ID: WP_001064799.1
Location: 438958..440349 (1392 bp)
Type: Others
Protein ID: WP_000211321.1
Location: 440346..441224 (879 bp)
Type: Others
Protein ID: WP_000988183.1
Location: 441235..442143 (909 bp)
Type: Others
Protein ID: WP_001247829.1
Location: 442130..442363 (234 bp)
Type: Others
Protein ID: WP_000618003.1
Location: 442360..442812 (453 bp)
Type: Others
Protein ID: WP_232626950.1
Location: 442870..443328 (459 bp)
Type: Others
Protein ID: WP_000961309.1
Location: 443911..444087 (177 bp)
Type: Others
Protein ID: WP_024260406.1
Location: 444084..444494 (411 bp)
Type: Others
Protein ID: WP_000814621.1
Location: 444491..444769 (279 bp)
Type: Others
Protein ID: WP_005061104.1
Location: 444844..447750 (2907 bp)
Type: Others
Protein ID: WP_005105712.1
Location: 447858..447974 (117 bp)
Type: Others
Protein ID: Protein_450
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EKN05_RS02280 (EKN05_002290)438409..438609-201WP_000111769.1protein ninH-
EKN05_RS02285 (EKN05_002295)438704..438961-258WP_001064799.1hypothetical protein-
EKN05_RS02290 (EKN05_002300)438958..440349-1392WP_000211321.1replicative DNA helicase-
EKN05_RS02295 (EKN05_002305)440346..441224-879WP_000988183.1ATP-binding protein-
EKN05_RS02300 (EKN05_002310)441235..442143-909WP_001247829.1hypothetical protein-
EKN05_RS02305 (EKN05_002315)442130..442363-234WP_000618003.1hypothetical protein-
EKN05_RS25530442360..442812-453WP_232626950.1Rha family transcriptional regulator-
EKN05_RS25535442870..443328-459WP_000961309.1ash family protein-
EKN05_RS02315 (EKN05_002325)443341..443571+231WP_005061113.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EKN05_RS02320 (EKN05_002330)443561..443869+309WP_000147081.1helix-turn-helix transcriptional regulatorAntitoxin
EKN05_RS02325 (EKN05_002335)443911..444087-177WP_024260406.1NinE family protein-
EKN05_RS02330 (EKN05_002340)444084..444494-411WP_000814621.1recombination protein NinB-
EKN05_RS02335 (EKN05_002345)444491..444769-279WP_005061104.1hypothetical protein-
EKN05_RS02340 (EKN05_002350)444844..447750-2907WP_005105712.1toprim domain-containing protein-
EKN05_RS02345 (EKN05_002355)447858..447974-117Protein_450helix-turn-helix domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--407819..45634748528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(5-70)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8665.12 Da        Isoelectric Point: 10.5308

>T120361 WP_005061113.1 NZ_CP037923:443341-443571 [Shigella flexneri 5a str. M90T]
MKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIMLHSFVKKAQKTPPAERKKAETRMKEVKHDW

Download         Length: 231 bp

>T120361 NZ_CP037923:443341-443571 [Shigella flexneri 5a str. M90T]
ATGAAGGTATACGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGACGGGCTTTTCGAACTCAGAATTAAAGG
CAACGATGGGATCGCGCGTGTTTTTTACTGCACTCTGACAGGGAAACGCATCATCATGCTGCATAGTTTTGTAAAGAAAG
CGCAGAAAACACCGCCAGCCGAACGCAAGAAAGCTGAAACCAGAATGAAGGAGGTTAAGCATGACTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11185.94 Da        Isoelectric Point: 8.5840

>AT120361 WP_000147081.1 NZ_CP037923:443561-443869 [Shigella flexneri 5a str. M90T]
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV

Download         Length: 309 bp

>AT120361 NZ_CP037923:443561-443869 [Shigella flexneri 5a str. M90T]
ATGACTGGTAAACGCACTCTCCCCACCATGACACACGACGAAATGGCAGCCAAATGGATGGAAGACCCGGCTTTTAAAGC
AGAATACGACGCTATCGCTGACGAATTCGCACTGCTTGATGAAATGCTGGCAGCACGCAAAGAAGCTGGCTTAACTCAGG
CTGAAGTTGCCGAGCGAATGGGAACAAAAGCGACCGCGATCACCAGAATGGAAAGTAATCTCGCATCAGGTATCAGCGGC
CCATCATTTGCCACACTAAAAAAATTCGCCCGCGCTACTGGAAAAAAACTCCAGATCCGCTTCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A4P7TJC1

References