Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1407475..1407846 Replicon chromosome
Accession NZ_CP037857
Organism Escherichia coli BW25113 strain AM187

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag E1A98_RS06940 Protein ID WP_001317028.1
Coordinates 1407652..1407846 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1407475..1407653 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1A98_RS06915 1403430..1404803 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
E1A98_RS06920 1404932..1405867 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
E1A98_RS06925 1405919..1407154 - 1236 WP_000040852.1 site-specific integrase -
E1A98_RS06930 1407156..1407371 - 216 WP_000079604.1 excisionase XisR -
E1A98_RS06935 1407450..1407659 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1407475..1407653 + 179 NuclAT_0 - Antitoxin
- 1407475..1407653 + 179 NuclAT_0 - Antitoxin
- 1407475..1407653 + 179 NuclAT_0 - Antitoxin
- 1407475..1407653 + 179 NuclAT_0 - Antitoxin
E1A98_RS06940 1407652..1407846 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
E1A98_RS06945 1407903..1408712 - 810 WP_000166319.1 recombination protein RecT -
E1A98_RS06950 1408705..1411305 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
E1A98_RS06955 1411407..1411682 - 276 WP_000632297.1 protein RacC -
E1A98_RS06960 1411757..1411927 - 171 WP_001352098.1 conserved protein, Rac prophage -
E1A98_RS06965 1411927..1412148 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1405919..1427593 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T120207 WP_001317028.1 NZ_CP037857:c1407846-1407652 [Escherichia coli BW25113]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T120207 NZ_CP037857:c1407846-1407652 [Escherichia coli BW25113]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT120207 NZ_CP037857:1407475-1407653 [Escherichia coli BW25113]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References