Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 381109..381875 Replicon chromosome
Accession NZ_CP036500
Organism Vibrio cholerae strain 20000

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag EZZ25_RS15920 Protein ID WP_000982260.1
Coordinates 381109..381606 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag EZZ25_RS15925 Protein ID WP_000246253.1
Coordinates 381603..381875 (-) Length 91 a.a.

Genomic Context

EZZ25_RS15865EZZ25_RS15870EZZ25_RS15875EZZ25_RS15880EZZ25_RS15885EZZ25_RS15890EZZ25_RS15895EZZ25_RS15900EZZ25_RS15905EZZ25_RS15910EZZ25_RS15930EZZ25_RS15935EZZ25_RS19430EZZ25_RS15940EZZ25_RS15955EZZ25_RS19355EZZ25_RS15970EZZ25_RS15975EZZ25_RS15985EZZ25_RS15920EZZ25_RS15925
Location: 376533..376703 (171 bp)
Type: Others
Protein ID: WP_000483444.1
Location: 376882..377542 (661 bp)
Type: Others
Protein ID: Protein_366
Location: 377679..378185 (507 bp)
Type: Others
Protein ID: Protein_367
Location: 378304..378741 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 378823..378993 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 378993..379394 (402 bp)
Type: Others
Protein ID: Protein_370
Location: 379364..379507 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 379592..379843 (252 bp)
Type: Others
Protein ID: WP_088124792.1
Location: 379977..380432 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 380754..380906 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 382106..382774 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 382926..383213 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 383373..383477 (105 bp)
Type: Others
Protein ID: Protein_379
Location: 383535..383969 (435 bp)
Type: Others
Protein ID: WP_000453958.1
Location: 384124..384627 (504 bp)
Type: Others
Protein ID: WP_001898452.1
Location: 384819..385322 (504 bp)
Type: Others
Protein ID: WP_001898452.1
Location: 385550..385807 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 385795..386097 (303 bp)
Type: Others
Protein ID: WP_000229325.1
Location: 386482..386592 (111 bp)
Type: Others
Protein ID: WP_076025930.1
Location: 381109..381606 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 381603..381875 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EZZ25_RS15865376533..376703+171WP_000483444.1DUF645 family protein-
EZZ25_RS15870376882..377542+661Protein_366Vat family streptogramin A O-acetyltransferase-
EZZ25_RS15875377679..378185+507Protein_367GNAT family N-acetyltransferase-
EZZ25_RS15880378304..378741+438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
EZZ25_RS15885378823..378993+171WP_001080654.1hypothetical protein-
EZZ25_RS15890378993..379394+402Protein_370type II toxin-antitoxin system death-on-curing family toxin-
EZZ25_RS15895379364..379507+144WP_071908341.1DUF3265 domain-containing protein-
EZZ25_RS15900379592..379843+252WP_088124792.1TIGR03643 family protein-
EZZ25_RS15905379977..380432+456WP_001245327.1GNAT family N-acetyltransferase-
EZZ25_RS15910380754..380906+153WP_001884520.1DUF645 family protein-
EZZ25_RS15920381109..381606-498WP_000982260.1GNAT family N-acetyltransferaseToxin
EZZ25_RS15925381603..381875-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
EZZ25_RS15930382106..382774+669WP_000043871.1hypothetical protein-
EZZ25_RS15935382926..383213+288WP_000426470.1hypothetical protein-
EZZ25_RS19430383373..383477+105Protein_379PhzF family phenazine biosynthesis protein-
EZZ25_RS15940383535..383969+435WP_000453958.1GNAT family N-acetyltransferase-
EZZ25_RS15955384124..384627+504WP_001898452.1hypothetical protein-
EZZ25_RS19355384819..385322+504WP_001898452.1hypothetical protein-
EZZ25_RS15970385550..385807+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
EZZ25_RS15975385795..386097+303WP_000229325.1type II toxin-antitoxin system RelE/ParE family toxin-
EZZ25_RS15985386482..386592+111WP_076025930.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
flankIS/Tn--378304..378741437
-insideIntegron--322986..40361480628


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T119901 WP_000982260.1 NZ_CP036500:c381606-381109 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T119901 NZ_CP036500:c381606-381109 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT119901 WP_000246253.1 NZ_CP036500:c381875-381603 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT119901 NZ_CP036500:c381875-381603 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References