Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 375663..376210 | Replicon | chromosome |
| Accession | NZ_CP036500 | ||
| Organism | Vibrio cholerae strain 20000 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | EZZ25_RS15850 | Protein ID | WP_131476981.1 |
| Coordinates | 375908..376210 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | EZZ25_RS15845 | Protein ID | WP_000861987.1 |
| Coordinates | 375663..375920 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EZZ25_RS15810 | 371385..372574 | + | 1190 | WP_131477000.1 | IS3 family transposase | - |
| EZZ25_RS15815 | 372602..373108 | + | 507 | WP_131476979.1 | GNAT family N-acetyltransferase | - |
| EZZ25_RS15820 | 373165..373251 | + | 87 | WP_080385990.1 | acetyltransferase | - |
| EZZ25_RS15825 | 373248..373544 | + | 297 | WP_000617997.1 | Dabb family protein | - |
| EZZ25_RS15830 | 373818..374243 | + | 426 | WP_000415750.1 | hypothetical protein | - |
| EZZ25_RS15835 | 374441..374938 | + | 498 | WP_000259905.1 | GNAT family N-acetyltransferase | - |
| EZZ25_RS15840 | 375233..375412 | + | 180 | WP_025998961.1 | DUF645 family protein | - |
| EZZ25_RS15845 | 375663..375920 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| EZZ25_RS15850 | 375908..376210 | + | 303 | WP_131476981.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EZZ25_RS15865 | 376533..376703 | + | 171 | WP_000483444.1 | DUF645 family protein | - |
| EZZ25_RS15870 | 376882..377542 | + | 661 | Protein_366 | Vat family streptogramin A O-acetyltransferase | - |
| EZZ25_RS15875 | 377679..378185 | + | 507 | Protein_367 | GNAT family N-acetyltransferase | - |
| EZZ25_RS15880 | 378304..378741 | + | 438 | WP_000503164.1 | IS200/IS605-like element IS1004 family transposase | - |
| EZZ25_RS15885 | 378823..378993 | + | 171 | WP_001080654.1 | hypothetical protein | - |
| EZZ25_RS15890 | 378993..379394 | + | 402 | Protein_370 | type II toxin-antitoxin system death-on-curing family toxin | - |
| EZZ25_RS15895 | 379364..379507 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| EZZ25_RS15900 | 379592..379843 | + | 252 | WP_088124792.1 | TIGR03643 family protein | - |
| EZZ25_RS15905 | 379977..380432 | + | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
| EZZ25_RS15910 | 380754..380906 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| flank | IS/Tn | - | - | 378304..378741 | 437 | ||
| - | inside | Integron | - | - | 322986..403614 | 80628 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11739.64 Da Isoelectric Point: 4.8838
>T119900 WP_131476981.1 NZ_CP036500:375908-376210 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNLCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNLCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T119900 NZ_CP036500:375908-376210 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCTGTGTCGTGTTTTCTACAAGTATGATGATGCAAATGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCTGTGTCGTGTTTTCTACAAGTATGATGATGCAAATGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT119900 WP_000861987.1 NZ_CP036500:375663-375920 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT119900 NZ_CP036500:375663-375920 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|