MGE detailed information
MGE type: Conjugative plasmid MGE length: 128932 bp
Accession: NZ_CP027802 Location: 1..128932 Organism: Klebsiella pneumoniae subsp. pneumoniae strain VH1-2 Replicon: plasmid pVH1-2-KPC
Accession: NZ_CP027802 Location: 1..128932 Organism: Klebsiella pneumoniae subsp. pneumoniae strain VH1-2 Replicon: plasmid pVH1-2-KPC
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C7K65_RS27035 (968) | 968..1984 | + | 1017 | Protein_1 | RepB family plasmid replication initiator protein | - |
| C7K65_RS27040 (2189) | 2189..2929 | - | 741 | WP_001066952.1 | tyrosine-type recombinase/integrase | - |
| C7K65_RS27045 (3051) | 3051..3239 | - | 189 | WP_001309252.1 | hypothetical protein | - |
| C7K65_RS27050 (3606) | 3606..4775 | + | 1170 | WP_001072358.1 | hypothetical protein | - |
| C7K65_RS27060 (5721) | 5721..5953 | - | 233 | Protein_6 | hypothetical protein | - |
| C7K65_RS27065 (6399) | 6399..6671 | - | 273 | WP_001322642.1 | Major pilu subunit operon regulatory protein PapB | VF |
| C7K65_RS27070 (7208) | 7208..7632 | - | 425 | Protein_8 | IS3 family transposase IS2 | Transposase |
| C7K65_RS27075 (7914) | 7914..9884 | + | 1971 | WP_001496335.1 | Hemin receptor | VF |
| C7K65_RS27080 (9891) | 9891..10682 | + | 792 | WP_000977394.1 | DUF4198 domain-containing protein | - |
| C7K65_RS27085 (10745) | 10745..11353 | - | 609 | Protein_11 | IS66 family transposase ISEc22 | Transposase |
| C7K65_RS27090 (11421) | 11421..12203 | - | 783 | WP_001317493.1 | IS21 family transposase IS100kyp | Transposase |
| C7K65_RS27095 (12200) | 12200..13135 | - | 936 | Protein_13 | IS21 family transposase IS100kyp | Transposase |
| C7K65_RS27100 (13185) | 13185..13889 | - | 705 | WP_001067845.1 | IS6 family transposase IS26 | Transposase |
| C7K65_RS27105 (14236) | 14236..15249 | - | 1014 | WP_000845048.1 | IS91 family transposase ISAzo26 | Transposase |
| C7K65_RS27110 (15429) | 15429..15983 | + | 555 | WP_032488579.1 | aminoglycoside N-acetyltransferase AAC(6')-Ib3 | - |
| C7K65_RS27115 (16250) | 16250..17509 | + | 1260 | Protein_17 | Inner membrane transport protein YdhC | ARG |
| C7K65_RS27120 (17733) | 17733..18701 | + | 969 | WP_013362812.1 | IS5 family transposase IS903B | Transposase |
| C7K65_RS27125 (18758) | 18758..19855 | + | 1098 | Protein_19 | TonB-dependent receptor | - |
| C7K65_RS27130 (19923) | 19923..20399 | - | 477 | Protein_20 | PAS domain-containing protein | - |
| C7K65_RS27135 (20452) | 20452..21156 | - | 705 | WP_001067845.1 | IS6 family transposase IS26 | Transposase |
| C7K65_RS27140 (21193) | 21193..21382 | - | 190 | Protein_22 | Tn3 family transposase | - |
| C7K65_RS27145 (21712) | 21712..22572 | - | 861 | WP_000027057.1 | Beta-lactamase TEM | ARG |
| C7K65_RS27150 (22755) | 22755..23153 | - | 399 | Protein_24 | Tn3 family transposase TnpR_Tn3 | Transposase |
| C7K65_RS27155 (23216) | 23216..23920 | + | 705 | WP_001067845.1 | IS6 family transposase IS26 | Transposase |
| C7K65_RS27160 (24007) | 24007..24354 | - | 348 | WP_000142451.1 | DUF6404 family protein | - |
| C7K65_RS27165 (24483) | 24483..24818 | + | 336 | WP_001080730.1 | colicin 1A immunity protein | - |
| C7K65_RS27170 (24840) | 24840..25208 | - | 369 | Protein_28 | colicin-like pore-forming protein | - |
| C7K65_RS27175 (25273) | 25273..25970 | + | 698 | WP_095033700.1 | IS1 family transposase IS1R | Transposase |
| C7K65_RS27180 (26020) | 26020..26295 | - | 276 | WP_000421257.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin Detail |
| C7K65_RS27185 (26295) | 26295..26579 | - | 285 | WP_001178089.1 | ribbon-helix-helix domain-containing protein | Antitoxin Detail |
| C7K65_RS27190 (27090) | 27090..27794 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| C7K65_RS27195 (28200) | 28200..28817 | + | 618 | Protein_33 | replication protein | - |
| C7K65_RS27200 (29351) | 29351..29629 | + | 279 | WP_013213990.1 | hypothetical protein | - |
| C7K65_RS27205 (29740) | 29740..30165 | + | 426 | WP_013213989.1 | antirestriction protein | - |
| C7K65_RS27210 (30293) | 30293..30448 | + | 156 | WP_013213988.1 | hypothetical protein | - |
| C7K65_RS27215 (30494) | 30494..30790 | + | 297 | WP_013213987.1 | transcriptional regulator | - |
| C7K65_RS27220 (30894) | 30894..31775 | + | 882 | Protein_38 | IS1182 family transposase ISKpn6 | Transposase |
| C7K65_RS27225 (32025) | 32025..32906 | - | 882 | WP_004199234.1 | Carbapenem-hydrolyzing beta-lactamase KPC | ARG |
| C7K65_RS27230 (33182) | 33182..34162 | - | 981 | WP_013213985.1 | IS481 family transposase ISKpn27 | Transposase |
| C7K65_RS27235 (34285) | 34285..34746 | - | 462 | Protein_41 | Tn3 family transposase TnpR_Tn3 | Transposase |
| C7K65_RS27240 (34798) | 34798..35502 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| C7K65_RS27245 (35971) | 35971..36534 | - | 564 | WP_155082050.1 | hypothetical protein | - |
| C7K65_RS27250 (36656) | 36656..37198 | - | 543 | WP_077273850.1 | restriction endonuclease | - |
| C7K65_RS27255 (37180) | 37180..38160 | - | 981 | WP_000019445.1 | IS5 family transposase ISKpn26 | Transposase |
| C7K65_RS27260 (38491) | 38491..38892 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| C7K65_RS27265 (38825) | 38825..39082 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| C7K65_RS27270 (39175) | 39175..39828 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| C7K65_RS27275 (40767) | 40767..41624 | - | 858 | WP_016240488.1 | incFII family plasmid replication initiator RepA | - |
| C7K65_RS27280 (41617) | 41617..41691 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| C7K65_RS27285 (41936) | 41936..42184 | - | 249 | WP_000083839.1 | replication regulatory protein RepA | - |
| C7K65_RS27290 (42469) | 42469..42618 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin Detail |
| - (42663) | 42663..42722 | + | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (42663) | 42663..42722 | + | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (42663) | 42663..42722 | + | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (42663) | 42663..42722 | + | 60 | NuclAT_1 | - | Antitoxin Detail |
| C7K65_RS27295 (42865) | 42865..43338 | - | 474 | WP_016240489.1 | hypothetical protein | - |
| C7K65_RS27300 (43493) | 43493..44083 | - | 591 | WP_033807967.1 | DUF2726 domain-containing protein | - |
| C7K65_RS27305 (44121) | 44121..44330 | - | 210 | WP_001298565.1 | hemolysin expression modulator Hha | - |
| C7K65_RS27310 (44376) | 44376..44837 | - | 462 | WP_001233838.1 | thermonuclease family protein | - |
| C7K65_RS27315 (45082) | 45082..45294 | - | 213 | WP_001309245.1 | ANR family transcriptional regulator | - |
| C7K65_RS27320 (45423) | 45423..45983 | - | 561 | WP_000139321.1 | fertility inhibition protein FinO | - |
| C7K65_RS27325 (46086) | 46086..46946 | - | 861 | WP_000704523.1 | putative protein YcjY | VF |
| C7K65_RS27330 (47005) | 47005..47751 | - | 747 | WP_059338983.1 | conjugal transfer pilus acetylase TraX | - |
| C7K65_RS27335 (47771) | 47771..53041 | - | 5271 | WP_172691999.1 | Multifunctional conjugation protein TraI | Relaxase |
| C7K65_RS27340 (53041) | 53041..55320 | - | 2280 | WP_087760849.1 | Coupling protein TraD | VF |
| C7K65_RS27345 (55371) | 55371..56108 | - | 738 | WP_000199905.1 | hypothetical protein | - |
| C7K65_RS27350 (56311) | 56311..57042 | - | 732 | WP_000782451.1 | conjugal transfer complement resistance protein TraT | - |
| C7K65_RS27355 (57091) | 57091..57576 | - | 486 | WP_000605870.1 | hypothetical protein | - |
| C7K65_RS27360 (57592) | 57592..60414 | - | 2823 | WP_001007039.1 | conjugal transfer mating-pair stabilization protein TraG | - |
| C7K65_RS27365 (60411) | 60411..61793 | - | 1383 | WP_001309243.1 | conjugal transfer pilus assembly protein TraH | - |
| C7K65_RS27370 (61771) | 61771..62163 | - | 393 | WP_000660699.1 | F-type conjugal transfer protein TrbF | - |
| C7K65_RS27375 (62144) | 62144..62491 | - | 348 | WP_001309242.1 | P-type conjugative transfer protein TrbJ | - |
| C7K65_RS27380 (62421) | 62421..62966 | - | 546 | WP_000059831.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| C7K65_RS27385 (62953) | 62953..63237 | - | 285 | WP_000624194.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| C7K65_RS27390 (63356) | 63356..63700 | - | 345 | WP_000556796.1 | conjugal transfer protein TrbA | - |
| C7K65_RS27395 (63714) | 63714..64463 | - | 750 | WP_001336806.1 | type-F conjugative transfer system pilin assembly protein TraF | - |
| C7K65_RS27400 (64450) | 64450..64707 | - | 258 | WP_000864353.1 | conjugal transfer protein TrbE | - |
| C7K65_RS27405 (64734) | 64734..66584 | - | 1851 | WP_000821856.1 | type-F conjugative transfer system mating-pair stabilization protein TraN | - |
| C7K65_RS27410 (66581) | 66581..67219 | - | 639 | WP_001080256.1 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| C7K65_RS27415 (67228) | 67228..67533 | - | 306 | WP_000224416.1 | hypothetical protein | - |
| C7K65_RS27420 (67563) | 67563..68555 | - | 993 | WP_000830838.1 | conjugal transfer pilus assembly protein TraU | - |
| C7K65_RS27425 (68552) | 68552..69184 | - | 633 | WP_001203728.1 | type-F conjugative transfer system protein TraW | - |
| C7K65_RS27430 (69181) | 69181..69567 | - | 387 | WP_000214084.1 | type-F conjugative transfer system protein TrbI | - |
| C7K65_RS27435 (69564) | 69564..72194 | - | 2631 | WP_000069777.1 | type IV secretion system protein TraC | - |
| C7K65_RS27440 (72320) | 72320..72667 | - | 348 | WP_000836682.1 | hypothetical protein | - |
| C7K65_RS27445 (72695) | 72695..72913 | - | 219 | WP_000556745.1 | hypothetical protein | - |
| C7K65_RS27450 (72993) | 72993..73469 | - | 477 | WP_000549587.1 | hypothetical protein | - |
| C7K65_RS27455 (73462) | 73462..73683 | - | 222 | WP_001278683.1 | conjugal transfer protein TraR | - |
| C7K65_RS27460 (73818) | 73818..74333 | - | 516 | WP_000809881.1 | type IV conjugative transfer system lipoprotein TraV | - |
| C7K65_RS27465 (74330) | 74330..74650 | - | 321 | WP_001057307.1 | conjugal transfer protein TrbD | - |
| C7K65_RS27470 (74637) | 74637..75203 | - | 567 | WP_000896599.1 | conjugal transfer pilus-stabilizing protein TraP | - |
| C7K65_RS27475 (75193) | 75193..76644 | - | 1452 | WP_000146675.1 | F-type conjugal transfer pilus assembly protein TraB | - |
| C7K65_RS27480 (76644) | 76644..77372 | - | 729 | WP_001230772.1 | type-F conjugative transfer system secretin TraK | - |
| C7K65_RS27485 (77359) | 77359..77925 | - | 567 | WP_000399780.1 | type IV conjugative transfer system protein TraE | - |
| C7K65_RS27490 (77947) | 77947..78258 | - | 312 | WP_000012113.1 | type IV conjugative transfer system protein TraL | - |
| C7K65_RS27495 (78273) | 78273..78632 | - | 360 | WP_001098992.1 | type IV conjugative transfer system pilin TraA | - |
| C7K65_RS27500 (78665) | 78665..78892 | - | 228 | WP_000089263.1 | conjugal transfer relaxosome protein TraY | - |
| C7K65_RS27505 (79029) | 79029..79700 | - | 672 | WP_000283561.1 | conjugal transfer transcriptional regulator TraJ | - |
| C7K65_RS27510 (79894) | 79894..80277 | - | 384 | WP_001354030.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| C7K65_RS27515 (80612) | 80612..81202 | + | 591 | WP_000252683.1 | hypothetical protein | VF |
| C7K65_RS27520 (81499) | 81499..82320 | - | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
| C7K65_RS27525 (82431) | 82431..82727 | - | 297 | WP_001272251.1 | hypothetical protein | - |
| C7K65_RS27530 (83027) | 83027..83323 | + | 297 | Protein_100 | hypothetical protein | - |
| C7K65_RS27535 (83642) | 83642..83767 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| C7K65_RS27540 (83709) | 83709..83858 | - | 150 | Protein_102 | plasmid maintenance protein Mok | - |
| - (83844) | 83844..84068 | - | 225 | NuclAT_0 | - | Antitoxin Detail |
| - (83844) | 83844..84068 | - | 225 | NuclAT_0 | - | Antitoxin Detail |
| - (83844) | 83844..84068 | - | 225 | NuclAT_0 | - | Antitoxin Detail |
| - (83844) | 83844..84068 | - | 225 | NuclAT_0 | - | Antitoxin Detail |
| C7K65_RS27545 (84080) | 84080..84799 | - | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
| C7K65_RS27550 (84796) | 84796..85230 | - | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
| C7K65_RS27555 (85299) | 85299..87322 | - | 2024 | Protein_105 | ParB/RepB/Spo0J family partition protein | - |
| C7K65_RS27560 (87383) | 87383..87616 | - | 234 | WP_000006003.1 | DUF905 family protein | - |
| C7K65_RS27565 (87674) | 87674..88201 | - | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
| C7K65_RS27570 (88503) | 88503..88952 | + | 450 | Protein_108 | hypothetical protein | - |
| C7K65_RS27575 (89038) | 89038..89601 | - | 564 | WP_001298559.1 | class I SAM-dependent methyltransferase | - |
| C7K65_RS27580 (89648) | 89648..91009 | - | 1362 | WP_000170695.1 | DUF3560 domain-containing protein | - |
| C7K65_RS27585 (91061) | 91061..91291 | - | 231 | WP_000218642.1 | hypothetical protein | - |
| C7K65_RS27590 (91808) | 91808..91962 | + | 155 | Protein_112 | hypothetical protein | - |
| C7K65_RS27595 (92691) | 92691..94358 | + | 1668 | WP_012372796.1 | group II intron reverse transcriptase/maturase | - |
| C7K65_RS27600 (94672) | 94672..94863 | - | 192 | WP_001027495.1 | hypothetical protein | - |
| C7K65_RS27605 (94860) | 94860..95282 | - | 423 | WP_000271762.1 | DUF1380 family protein | - |
| C7K65_RS27610 (95329) | 95329..95754 | - | 426 | WP_089079046.1 | antirestriction protein | - |
| C7K65_RS27615 (96168) | 96168..96938 | - | 771 | WP_001006225.1 | hypothetical protein | - |
| C7K65_RS27620 (96983) | 96983..97469 | - | 487 | Protein_118 | DUF1380 domain-containing protein | - |
| C7K65_RS27625 (97429) | 97429..97650 | - | 222 | WP_001104887.1 | hypothetical protein | - |
| C7K65_RS27630 (97651) | 97651..98334 | - | 684 | WP_000086160.1 | DNA methylase | - |
| C7K65_RS27635 (98410) | 98410..98715 | - | 306 | WP_032155763.1 | hypothetical protein | - |
| C7K65_RS27640 (98719) | 98719..99621 | - | 903 | WP_001302618.1 | DUF1281 domain-containing protein | - |
| C7K65_RS27645 (100039) | 100039..100287 | + | 249 | WP_000618110.1 | DinI-like family protein | - |
| C7K65_RS27650 (100284) | 100284..100721 | + | 438 | WP_000109071.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| C7K65_RS27655 (100721) | 100721..101992 | + | 1272 | WP_000457496.1 | Y-family DNA polymerase | - |
| C7K65_RS27660 (101997) | 101997..102389 | - | 393 | WP_000340829.1 | plasmid partitioning/stability family protein | - |
| C7K65_RS27665 (102394) | 102394..103365 | - | 972 | WP_001103697.1 | plasmid segregation protein ParM | - |
| C7K65_RS27670 (103594) | 103594..104238 | + | 645 | WP_000633913.1 | division plane positioning ATPase MipZ | - |
| C7K65_RS27675 (104232) | 104232..104507 | + | 276 | WP_000239529.1 | hypothetical protein | - |
| C7K65_RS27680 (104699) | 104699..105125 | - | 427 | Protein_130 | site-specific integrase | - |
| C7K65_RS27685 (105305) | 105305..105895 | + | 591 | Protein_131 | colicin-B | - |
| C7K65_RS27695 (106664) | 106664..106858 | - | 195 | Protein_133 | colicin M immunity protein | - |
| C7K65_RS27700 (107030) | 107030..107839 | - | 810 | WP_000016963.1 | site-specific integrase | - |
| C7K65_RS27705 (107840) | 107840..108145 | - | 306 | WP_001159871.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| C7K65_RS27710 (108147) | 108147..108365 | - | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin Detail |
| C7K65_RS27715 (108926) | 108926..109156 | + | 231 | WP_001261286.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin Detail |
| C7K65_RS27720 (109153) | 109153..109569 | + | 417 | WP_001034044.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| C7K65_RS27725 (109644) | 109644..111209 | + | 1566 | WP_001128474.1 | AAA family ATPase | - |
| C7K65_RS27730 (111194) | 111194..112216 | + | 1023 | WP_000361402.1 | helicase UvrD | - |
| C7K65_RS27735 (112470) | 112470..113156 | - | 687 | Protein_141 | IS1 family transposase IS1S | Transposase |
| C7K65_RS27740 (113211) | 113211..114371 | - | 1161 | Protein_142 | Ferric aerobactin receptor | VF |
| C7K65_RS27745 (114403) | 114403..115736 | - | 1334 | Protein_143 | L-lysine N6-monooxygenase | VF |
| C7K65_RS27750 (115733) | 115733..117475 | - | 1743 | WP_001015721.1 | Aerobactin synthase | VF |
| C7K65_RS27755 (117475) | 117475..118422 | - | 948 | WP_000011908.1 | N(6)-hydroxylysine O-acetyltransferase | VF |
| C7K65_RS27760 (118423) | 118423..120147 | - | 1725 | WP_000602863.1 | N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase | VF |
| C7K65_RS27765 (120283) | 120283..121476 | + | 1194 | WP_000095526.1 | MFS transporter | - |
| C7K65_RS27770 (121856) | 121856..122236 | - | 381 | WP_001318207.1 | fluoride efflux transporter CrcB | - |
| C7K65_RS27775 (122577) | 122577..122990 | - | 414 | Protein_149 | phosphopyruvate hydratase | - |
| C7K65_RS27780 (122988) | 122988..123245 | + | 258 | Protein_150 | transposase | - |
| C7K65_RS27785 (123479) | 123479..124336 | - | 858 | WP_000968139.1 | Manganese transport system membrane protein MntB | ARG |
| C7K65_RS27790 (124333) | 124333..125190 | - | 858 | WP_001101723.1 | Manganese transport system membrane protein MntB | ARG |
| C7K65_RS27795 (125187) | 125187..126014 | - | 828 | WP_000983710.1 | Iron(3+)-hydroxamate import ATP-binding protein FhuC | VF |
| C7K65_RS27800 (126014) | 126014..126928 | - | 915 | WP_000949005.1 | Putative metal ABC transporter substrate-binding protein Hpf | VF |
| C7K65_RS27805 (127284) | 127284..127970 | + | 687 | Protein_155 | IS1 family transposase | - |
| C7K65_RS27810 (128150) | 128150..128663 | - | 514 | Protein_156 | DUF4113 domain-containing protein | - |
| C7K65_RS27815 (128724) | 128724..128828 | - | 105 | Protein_157 | AAA family ATPase | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|