 T4SS ID | 386 |
| Strain | Bordetella pertussis Tohama I |
| Replicon | chromosome [Browse all T4SS(s) in this replicon] |
| Accession | NC_002929 |
| Location | 3991435..3999743 |
| Name | Ptl |
| Function | effector translocation |
| Classification | Type IVA; Type P |
 Experimental investigation has been performed on this T4SS. | |
T4SS components |
| Component | PtlA | PtlB | PtlC | PtlD | PtlI | PtlE | PtlF | PtlG | PtlH |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
The information of T4SS components from NC_002929 | ||||||
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| # | Locus tag (Gene) | Coordinates [+/-], size (bp) | Protein GI | Product | Component | |
| 1 | BP3782 | 3987011..3987991 [+], 981 | 33594637 | hypothetical protein | ||
| 2 | BP3783 (ptxA) | 3988258..3989067 [+], 810 | 33594638 | toxin subunit 1 | ||
| 3 | BP3784 (ptxB) | 3989107..3989787 [+], 681 | 33594639 | toxin subunit 2 | ||
| 4 | BP3785 (ptxD) | 3989781..3990239 [+], 459 | 33594640 | toxin subunit 4 | ||
| 5 | BP3786 (ptxE) | 3990212..3990613 [+], 402 | 33594641 | toxin subunit 5 | ||
| 6 | BP3787 (ptxC) | 3990696..3991379 [+], 684 | 33594642 | toxin subunit 3 | ||
| 7 | BP3788 (ptlA) | 3991435..3991743 [+], 309 | 33594643 | toxin transport protein | PtlA | |
| 8 | BP3789 (ptlB) | 3991762..3992076 [+], 315 | 33594644 | toxin transport protein | PtlB | |
| 9 | BP3790 | 3992073..3994547 [+], 2475 | 33594645 | secretion system protein | PtlC | |
| 10 | BP3791 | 3994555..3995946 [+], 1392 | 33594646 | hypothetical protein | PtlD | |
| 11 | BP3792 | 3995943..3996128 [+], 186 | 33594647 | secretion system protein | PtlI | |
| 12 | BP3793 | 3996107..3996808 [+], 702 | 33594648 | secretion system protein | PtlE | |
| 13 | BP3794 | 3996805..3997626 [+], 822 | 33594649 | secretion system protein | PtlF | |
| 14 | BP3795 | 3997607..3998731 [+], 1125 | 33594650 | secretion system protein | PtlG | |
| 15 | BP3796 | 3998724..3999743 [+], 1020 | 33594651 | secretion system protein | PtlH | |
| 16 | BP3797 | 3999949..4000839 [-], 891 | 33594652 | hypothetical protein | ||
| 17 | BP3798 | 4000982..4001875 [+], 894 | 33594653 | AraC family transcriptional regulator | ||
| 18 | BP3799 | 4001958..4002332 [+], 375 | 33594654 | hypothetical protein | ||
| 19 | BP3800 | 4002310..4003719 [+], 1410 | 33594655 | hypothetical protein | ||
 Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any. |
Download FASTA format files |
| Proteins Genes |
Effectors |
| PtxA, PtxB, PtxD, PtxE, PtxC |
The information of protein effectors | ||||||
| # | Locus tag (Gene) | Coordinates [+/-], size (bp) | Protein GI | Product | * | |
| 1 | BP3783 (ptxA) | 3988258..3989067 [+], 810 | 33594638 | toxin subunit 1 | PtxA | |
| 2 | BP3784 (ptxB) | 3989107..3989787 [+], 681 | 33594639 | toxin subunit 2 | PtxB | |
| 3 | BP3785 (ptxD) | 3989781..3990239 [+], 459 | 33594640 | toxin subunit 4 | PtxD | |
| 4 | BP3786 (ptxE) | 3990212..3990613 [+], 402 | 33594641 | toxin subunit 5 | PtxE | |
| 5 | BP3787 (ptxC) | 3990696..3991379 [+], 684 | 33594642 | toxin subunit 3 | PtxC | |
T4SE derived from experimental literature.Download FASTA format files |
| Proteins Genes |
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(1) Verma A; Cheung AM; Burns DL (2008). Stabilization of the pertussis toxin secretion apparatus by the C terminus of PtlD. J Bacteriol. 190(21):7285-90. [PudMed:18723610]
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(2) Rambow-Larsen AA; Weiss AA (2004). Temporal expression of pertussis toxin and Ptl secretion proteins by Bordetella pertussis. J Bacteriol. 186(1):43-50. [PudMed:14679223]
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| (3) Parkhill J; Sebaihia M; Preston A; Murphy LD; Thomson N; Harris DE; Holden MT; Churcher CM; Bentley SD; Mungall KL; Cerdeno-Tarraga AM; Temple L; James K; Harris B; Quail MA; Achtman M; Atkin R; Baker S; Basham D; Bason N; Cherevach I; Chillingworth T; Collins M; Cronin A; Davis P; Doggett J; Feltwell T; Goble A; Hamlin N; Hauser H; Holroyd S; Jagels K; Leather S; Moule S; Norberczak H; O'Neil S; Ormond D; Price C; Rabbinowitsch E; Rutter S; Sanders M; Saunders D; Seeger K; Sharp S; Simmonds M; Skelton J; Squares R; Squares S; Stevens K; Unwin L; Whitehead S; Barrell BG; Maskell DJ (2003). Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet. 35(1):32-40. [PudMed:12910271] |
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(4) Rambow-Larsen AA; Weiss AA (2002). The PtlE protein of Bordetella pertussis has peptidoglycanase activity required for Ptl-mediated pertussis toxin secretion. J Bacteriol. 184(11):2863-9. [PudMed:12003925]
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| This literature contains experimental investigation |