| Effector Protein ID: 33594638 |
 T4SS name [ID] | Ptl [386] |
| Gene symbol | ptxA |
| Locus tag | BP3783 |
| Strain | Bordetella pertussis Tohama I |
| Replicon | chromosome [GenBank: NC_002929] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 3988258..3989067 [+] |
| Product | toxin subunit 1 |
| Effector type | Protein |
| Descripton | PtxA |
| T4CP requirement | T4CP Indepedent |
| Target/Effection | A subunit of pertussis toxin (PT). PT is involved in the colonization of the respiratory tract and the establishment of infection of Bordetella pertussis causing whooping cough |
| UniProt ID | P04977 |
| KEGG ID | bpe:BP3783 |
| PDB ID | 1PTO, 1BCP, 1PRT |
| Domain hit(s) vs Pfam | Pertussis_S1 [PF02917], Evalue: 5.1e-132, Aligned region: 36..268 |
| Protein Sequence: 269 a.a. [Download] |
| >gi|33594638|ref|NP_882282.1| toxin subunit 1 [Bordetella pertussis Tohama I] MRCTRAIRQTARTGWLTWLAILAVTAPVTSPAWADDPPATVYRYDSRPPEDVFQNGFTAWGNNDNVLDHL TGRSCQVGSSNSAFVSTSSSRRYTEVYLEHRMQEAVEAERAGRGTGHFIGYIYEVRADNNFYGAASSYFE YVDTYGDNAGRILAGALATYQSEYLAHRRIPPENIRRVTRVYHNGITGETTTTEYSNARYVSQQTRANPN PYTSRRSVASIVGTLVRMAPVIGACMARQAESSEAMAAWSERAGEAMVLVYYESIAYSF |
| - |
| Nucleotide Sequence: 810 bp [Download] |
| >gi|33591275|ref|NC_002929.2|:3988258-3989067 Bordetella pertussis Tohama I chromosome, complete genome ATGCGTTGCACTCGGGCAATTCGCCAAACCGCAAGAACAGGCTGGCTGACGTGGCTGGCGATTCTTGCCG TCACGGCGCCCGTGACTTCGCCGGCATGGGCCGACGATCCTCCCGCCACCGTATACCGCTATGACTCCCG CCCGCCGGAGGACGTTTTCCAGAACGGATTCACGGCGTGGGGAAACAACGACAATGTGCTCGACCATCTG ACCGGACGTTCCTGCCAGGTCGGCAGCAGCAACAGCGCTTTCGTCTCCACCAGCAGCAGCCGGCGCTATA CCGAGGTCTATCTCGAACATCGCATGCAGGAAGCGGTCGAGGCCGAACGCGCCGGCAGGGGCACCGGCCA CTTCATCGGCTACATCTACGAAGTCCGCGCCGACAACAATTTCTACGGCGCCGCCAGCTCGTACTTCGAA TACGTCGACACTTATGGCGACAATGCCGGCCGTATCCTCGCCGGCGCGCTGGCCACCTACCAGAGCGAAT ATCTGGCACACCGGCGCATTCCGCCCGAAAACATCCGCAGGGTAACGCGGGTCTATCACAACGGCATCAC CGGCGAGACCACGACCACGGAGTATTCCAACGCTCGCTACGTCAGCCAGCAGACTCGCGCCAATCCCAAC CCCTACACATCGCGAAGGTCCGTAGCGTCGATCGTCGGCACATTGGTGCGCATGGCGCCGGTGATAGGCG CTTGCATGGCGCGGCAGGCCGAAAGCTCCGAGGCCATGGCAGCCTGGTCCGAACGCGCCGGCGAGGCGAT GGTTCTCGTGTACTACGAAAGCATCGCGTATTCGTTCTAG |
| Reference |
(1) Rambow-Larsen AA; Weiss AA (2004). Temporal expression of pertussis toxin and Ptl secretion proteins by Bordetella pertussis. J Bacteriol. 186(1):43-50. [PudMed:14679223] 
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| experimental literature |