| Effector Protein ID: 33594640 |
 T4SS name [ID] | Ptl [386] |
| Gene symbol | ptxD |
| Locus tag | BP3785 |
| Strain | Bordetella pertussis Tohama I |
| Replicon | chromosome [GenBank: NC_002929] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 3989781..3990239 [+] |
| Product | toxin subunit 4 |
| Effector type | Protein |
| Descripton | PtxD |
| T4CP requirement | T4CP Indepedent |
| Target/Effection | A subunit of pertussis toxin (PT). PT is involved in the colonization of the respiratory tract and the establishment of infection of Bordetella pertussis causing whooping cough |
| UniProt ID | P0A3R5 |
| KEGG ID | bpe:BP3785 |
| PDB ID | 1PTO, 1BCP, 1PRT |
| Domain hit(s) vs Pfam | Pertus-S4-tox [PF09275], Evalue: 7.3e-77, Aligned region: 43..152 |
| Protein Sequence: 152 a.a. [Download] |
| >gi|33594640|ref|NP_882284.1| toxin subunit 4 [Bordetella pertussis Tohama I] MLRRFPTRTTAPGQGGARRSRVRALAWLLASGAMTHLSPALADVPYVLVKTNMVVTSVAMKPYEVTPTRM LVCGIAAKLGAAASSPDAHVPFCFGKDLKRPGSSPMEVMLRAVFMQQRPLRMFLGPKQLTFEGKPALELI RMVECSGKQDCP |
| - |
| Nucleotide Sequence: 459 bp [Download] |
| >gi|33591275|ref|NC_002929.2|:3989781-3990239 Bordetella pertussis Tohama I chromosome, complete genome ATGCTGAGACGCTTCCCCACTCGAACCACCGCCCCGGGACAGGGCGGCGCCCGGCGGTCGCGCGTGCGCG CCCTGGCGTGGTTGCTGGCATCCGGCGCGATGACGCATCTTTCCCCCGCCCTGGCCGACGTTCCTTATGT GCTGGTGAAGACCAATATGGTGGTCACCAGCGTAGCCATGAAGCCGTATGAAGTCACCCCGACGCGCATG CTGGTCTGCGGCATCGCCGCCAAACTGGGCGCCGCGGCCAGCAGCCCGGACGCGCACGTGCCGTTCTGCT TCGGCAAGGATCTCAAGCGTCCCGGCAGCAGTCCCATGGAAGTCATGTTGCGCGCCGTCTTCATGCAACA ACGGCCGCTGCGCATGTTTCTGGGTCCCAAGCAACTCACTTTCGAAGGCAAGCCCGCGCTCGAACTGATC CGGATGGTCGAATGCAGCGGCAAGCAGGATTGCCCCTGA |
| Reference |
(1) Rambow-Larsen AA; Weiss AA (2004). Temporal expression of pertussis toxin and Ptl secretion proteins by Bordetella pertussis. J Bacteriol. 186(1):43-50. [PudMed:14679223] 
|
| experimental literature |