Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   EL086_RS00325 Genome accession   NZ_LR134274
Coordinates   56159..58102 (+) Length   647 a.a.
NCBI ID   WP_038675019.1    Uniprot ID   -
Organism   Streptococcus salivarius strain NCTC8618     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 51159..63102
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL086_RS00295 (NCTC8618_02473) argR 51364..51792 (+) 429 WP_171963651.1 arginine repressor -
  EL086_RS00300 (NCTC8618_02474) - 51792..52151 (+) 360 WP_038675011.1 YlbF family regulator -
  EL086_RS00305 (NCTC8618_02475) hexA 52171..54702 (+) 2532 WP_371212499.1 DNA mismatch repair protein MutS Machinery gene
  EL086_RS00310 (NCTC8618_02476) - 54736..55191 (-) 456 WP_002886315.1 DUF3021 domain-containing protein -
  EL086_RS00315 (NCTC8618_02477) - 55188..55625 (-) 438 WP_038675015.1 LytTR family DNA-binding domain-containing protein -
  EL086_RS00320 (NCTC8618_02478) - 55804..56106 (+) 303 WP_038675017.1 hypothetical protein -
  EL086_RS00325 (NCTC8618_02479) hexB 56159..58102 (+) 1944 WP_038675019.1 DNA mismatch repair endonuclease MutL Machinery gene
  EL086_RS00330 (NCTC8618_02480) - 58233..58454 (+) 222 WP_038675022.1 hypothetical protein -
  EL086_RS00335 (NCTC8618_02481) ruvA 58611..59201 (+) 591 WP_002886323.1 Holliday junction branch migration protein RuvA Machinery gene
  EL086_RS00340 (NCTC8618_02482) - 59210..59764 (+) 555 WP_002886325.1 DNA-3-methyladenine glycosylase I -
  EL086_RS00345 (NCTC8618_02483) cinA 59861..61129 (+) 1269 WP_014633777.1 competence/damage-inducible protein A Machinery gene
  EL086_RS00350 (NCTC8618_02484) recA 61165..62304 (+) 1140 WP_002886327.1 recombinase RecA Machinery gene
  EL086_RS00355 (NCTC8618_02485) spx 62472..62870 (+) 399 WP_002886328.1 transcriptional regulator Spx -

Sequence

Protein


Download         Length: 647 a.a.        Molecular weight: 72502.53 Da        Isoelectric Point: 5.2049

>NTDB_id=999535 EL086_RS00325 WP_038675019.1 56159..58102(+) (hexB) [Streptococcus salivarius strain NCTC8618]
MPKIIELPEVLANQIAAGEVVERPASVVKELVENAIDAGSTQITIEVEESGLSKIQITDNGEGMAQADVAMSLRRHATSK
IKNQGDLFRIRTLGFRGEALPSIASISHLTIVTAADGEAYGTKLVAKGGEIESQDPISTPVGTKITVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLLNDGRQLTQTSGTGDLRQAIAGIYGLTTAKKMVEISNSDLDFEVSGYVSLP
ELTRANRNYITILINGRYIKNFLLNRAIFDGYGSKLMVGRFPIAVIDIQIDPYLADVNVHPTKQEVRISKEKELMALISS
AIAQSLREQDLIPDALENLAKSSTRGAAKPVQTSLPLKQTNLYYDSSRNDFFVKPETVQEDIKPLVSESESPVSSVENKP
QPSVKQAQRSVDEGDSEHEKLDYKNKSKMKRMLENLDNEETSTFPELEFFGQMHGTYLFAQGQGGLYIIDQHAAQERVKY
EYYREKIGEVDSSLQQLLVPYLFEFSGSDYISLQEKMSLLNQVGIYLEPYGNNTFILREHPIWMKEEEIESAVYEMCDML
LLTNEVSVKTYRAELAIMMSCKRSIKANHALDDYSARDLLVQLAQCKNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHTS
LRDLGKY

Nucleotide


Download         Length: 1944 bp        

>NTDB_id=999535 EL086_RS00325 WP_038675019.1 56159..58102(+) (hexB) [Streptococcus salivarius strain NCTC8618]
ATGCCAAAAATCATCGAATTACCTGAGGTGTTAGCCAACCAGATTGCTGCTGGTGAGGTCGTAGAGCGCCCAGCCAGTGT
TGTCAAAGAGTTGGTGGAAAATGCTATTGATGCAGGCAGCACCCAGATTACCATTGAAGTTGAAGAATCAGGCCTCTCAA
AAATTCAAATCACAGACAATGGTGAAGGAATGGCTCAAGCTGATGTGGCCATGAGTTTGCGCCGTCATGCAACGAGTAAA
ATCAAAAATCAAGGAGATCTCTTTCGTATTCGAACCCTTGGTTTTCGAGGTGAGGCCCTACCATCAATAGCTTCTATCAG
CCACCTAACTATTGTGACAGCAGCGGATGGAGAAGCCTATGGGACTAAACTGGTTGCTAAAGGTGGAGAAATTGAGAGTC
AGGATCCTATTTCAACACCGGTTGGAACAAAGATTACCGTTGAAAATCTGTTTTATAACACCCCAGCTCGTCTCAAGTAT
ATGAAGAGTTTACAGGCTGAGTTGGCTCATATTGTCGATGTTGTCAATCGTCTGAGTCTAGCTCATCCCGAGGTTGCCTT
TACCTTGCTTAATGATGGTCGTCAGTTGACACAGACATCAGGTACTGGAGACCTCCGTCAAGCTATTGCTGGTATTTATG
GTTTGACAACGGCTAAAAAAATGGTGGAGATTTCAAATTCTGACCTTGATTTTGAAGTTTCTGGATATGTTAGTCTCCCT
GAGTTGACCCGTGCAAATCGTAACTACATCACGATTCTCATTAACGGACGTTATATTAAAAACTTCCTGCTTAACCGTGC
TATTTTTGATGGTTATGGTTCTAAACTCATGGTAGGACGCTTCCCTATTGCAGTTATTGATATTCAGATTGATCCCTACT
TGGCCGATGTCAATGTTCACCCAACCAAGCAGGAAGTACGTATTTCTAAAGAAAAAGAGCTCATGGCCCTTATCAGCTCT
GCCATTGCTCAAAGCCTTAGAGAGCAGGATTTGATTCCTGATGCCCTTGAAAATCTAGCCAAGTCTAGTACCAGAGGTGC
AGCTAAGCCAGTTCAAACCAGTCTTCCACTCAAACAAACCAATCTTTACTATGATAGCAGTCGTAATGATTTCTTTGTCA
AACCAGAGACAGTCCAAGAAGATATCAAACCTCTTGTATCAGAGTCAGAGTCTCCAGTTTCATCGGTAGAAAATAAACCG
CAACCTTCTGTTAAACAGGCACAACGTTCAGTAGATGAAGGTGATAGCGAACACGAAAAACTTGATTATAAAAACAAGTC
GAAAATGAAGCGCATGCTTGAAAATCTGGATAATGAGGAAACATCAACCTTCCCTGAATTAGAGTTTTTTGGTCAAATGC
ATGGAACCTATCTCTTTGCGCAAGGACAAGGCGGACTTTACATCATTGACCAGCATGCTGCTCAAGAACGTGTCAAGTAT
GAGTACTATCGTGAAAAGATTGGTGAGGTTGACAGCAGTTTACAACAGCTTTTGGTTCCTTATCTCTTTGAATTTTCAGG
TTCAGATTACATTAGTTTACAAGAAAAAATGTCCCTTCTTAACCAGGTTGGTATCTATTTAGAACCTTATGGGAACAACA
CTTTCATTCTTCGTGAACATCCTATCTGGATGAAGGAAGAAGAGATTGAATCAGCGGTCTATGAAATGTGTGACATGCTT
CTTTTGACGAATGAAGTGTCTGTTAAGACCTACCGTGCTGAGTTGGCCATCATGATGAGTTGTAAACGTTCAATCAAGGC
CAATCATGCTCTTGATGATTACTCTGCGCGTGACCTCCTAGTACAGCTTGCACAGTGTAAAAATCCCTACAATTGCCCTC
ACGGACGTCCAGTACTTGTCAACTTTACCAAGTCTGATATGGAAAAAATGTTCCGTCGTATCCAAGAAAATCATACAAGC
CTACGTGACCTAGGAAAGTATTAA

Domains

Predicted by InterProScan.

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(448-591)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-124)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

69.36

100

0.703