Detailed information NTG0997386

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ABC804_RS00425
• Genome accession: NZ_CP155536
• Coordinates: 64616..65368 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain M264-3
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 59616..70368

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC804_RS00395 (ABC804_00395)	spo0J	60206..60964 (-)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator
ABC804_RS00400 (ABC804_00400)	htrA	61022..62203 (-)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
ABC804_RS00405 (ABC804_00405)	rlmH	62386..62865 (+)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ABC804_RS00415 (ABC804_00415)	comC/comC1	63148..63273 (+)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
ABC804_RS00420 (ABC804_00420)	comD/comD1	63294..64619 (+)	1326	WP_014632435.1	competence system sensor histidine kinase ComD	Regulator
ABC804_RS00425 (ABC804_00425)	comE	64616..65368 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ABC804_RS00440 (ABC804_00440)	-	65610..66152 (-)	543	WP_001158255.1	TetR/AcrR family transcriptional regulator	-
ABC804_RS00445 (ABC804_00445)	-	66259..67933 (+)	1675	Protein_78	YhgE/Pip domain-containing protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=997386 ABC804_RS00425 WP_000866065.1 64616..65368(+) (comE) [Streptococcus pneumoniae strain M264-3]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=997386 ABC804_RS00425 WP_000866065.1 64616..65368(+) (comE) [Streptococcus pneumoniae strain M264-3]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408