Detailed information NTG0997130

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ABC810_RS08730
• Genome accession: NZ_CP155532
• Coordinates: 1723530..1724267 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain SP264
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1718530..1729267

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC810_RS08710 (ABC810_08700)	comA/nlmT	1718905..1720548 (+)	1644	WP_075270826.1	peptide cleavage/export ABC transporter	Regulator
ABC810_RS08715 (ABC810_08705)	-	1720559..1721920 (+)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
ABC810_RS08720 (ABC810_08710)	blpC	1721977..1722105 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
ABC810_RS08725 (ABC810_08715)	-	1722176..1723516 (-)	1341	WP_001017642.1	sensor histidine kinase	-
ABC810_RS08730 (ABC810_08720)	comE/blpR	1723530..1724267 (-)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
ABC810_RS08735 (ABC810_08725)	-	1724272..1724610 (-)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
ABC810_RS08740 (ABC810_08730)	-	1724886..1725215 (+)	330	WP_000132572.1	hypothetical protein	-
ABC810_RS08745 (ABC810_08735)	-	1725383..1726432 (-)	1050	WP_000653774.1	ABC transporter permease	-
ABC810_RS08750 (ABC810_08740)	pptA	1726429..1727160 (-)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
ABC810_RS08755 (ABC810_08745)	-	1727228..1727638 (+)	411	WP_001278301.1	HIT family protein	-
ABC810_RS08760 (ABC810_08750)	-	1727648..1727935 (+)	288	WP_000777753.1	hypothetical protein	-
ABC810_RS08765 (ABC810_08755)	-	1728097..1728381 (+)	285	WP_025169639.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=997130 ABC810_RS08730 WP_001219120.1 1723530..1724267(-) (comE/blpR) [Streptococcus pneumoniae strain SP264]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=997130 ABC810_RS08730 WP_001219120.1 1723530..1724267(-) (comE/blpR) [Streptococcus pneumoniae strain SP264]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363