Detailed information NTG0997053

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ABC803_RS08300
• Genome accession: NZ_CP155531
• Coordinates: 1598456..1599193 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219126.1
• Uniprot ID: A7XHJ0
• Organism: Streptococcus pneumoniae strain SN36255
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1593456..1604193

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC803_RS08280 (ABC803_08275)	-	1593777..1595138 (+)	1362	WP_001069099.1	bacteriocin secretion accessory protein	-
ABC803_RS08285 (ABC803_08280)	blpC	1595195..1595350 (+)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
ABC803_RS08290 (ABC803_08285)	-	1595517..1596863 (+)	1347	WP_001821303.1	IS1380-like element ISSpn5 family transposase	-
ABC803_RS08295 (ABC803_08290)	-	1597103..1598443 (-)	1341	WP_000275284.1	sensor histidine kinase	-
ABC803_RS08300 (ABC803_08295)	comE/blpR	1598456..1599193 (-)	738	WP_001219126.1	response regulator transcription factor	Regulator
ABC803_RS08305 (ABC803_08300)	-	1599198..1599536 (-)	339	WP_000682122.1	LytTR family DNA-binding domain-containing protein	-
ABC803_RS08310 (ABC803_08305)	-	1599812..1600141 (+)	330	WP_000132575.1	hypothetical protein	-
ABC803_RS08315 (ABC803_08310)	-	1600309..1601358 (-)	1050	WP_000653752.1	ABC transporter permease	-
ABC803_RS08320 (ABC803_08315)	pptA	1601355..1602086 (-)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
ABC803_RS08325 (ABC803_08320)	-	1602154..1602564 (+)	411	WP_001278301.1	HIT family protein	-
ABC803_RS08330 (ABC803_08325)	-	1602574..1602861 (+)	288	WP_000777760.1	hypothetical protein	-
ABC803_RS08335 (ABC803_08330)	-	1603023..1603217 (+)	195	WP_001808905.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.92 Da
• Isoelectric Point: 6.2357

>NTDB_id=997053 ABC803_RS08300 WP_001219126.1 1598456..1599193(-) (comE/blpR) [Streptococcus pneumoniae strain SN36255]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=997053 ABC803_RS08300 WP_001219126.1 1598456..1599193(-) (comE/blpR) [Streptococcus pneumoniae strain SN36255]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A7XHJ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384