Detailed information NTG0993626

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: UXR08_RS10375
• Genome accession: NZ_CP154497
• Coordinates: 2069829..2070872 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BSN57
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2064829..2075872

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
UXR08_RS10345 (UXR08_10345)	-	2065250..2066506 (-)	1257	WP_001795108.1	aminopeptidase	-
UXR08_RS10350 (UXR08_10350)	-	2066509..2066709 (-)	201	WP_000180460.1	DUF1128 family protein	-
UXR08_RS10355 (UXR08_10355)	-	2066856..2067320 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
UXR08_RS10360 (UXR08_10360)	-	2067327..2067602 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
UXR08_RS10365 (UXR08_10365)	-	2067880..2069097 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
UXR08_RS10370 (UXR08_10370)	vraR	2069210..2069839 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
UXR08_RS10375 (UXR08_10375)	vraS	2069829..2070872 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
UXR08_RS10380 (UXR08_10380)	liaF	2070869..2071570 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
UXR08_RS10385 (UXR08_10385)	-	2071585..2071971 (-)	387	WP_001110179.1	hypothetical protein	-
UXR08_RS10390 (UXR08_10390)	map	2072188..2072946 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
UXR08_RS10395 (UXR08_10395)	-	2073477..2074463 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
UXR08_RS10400 (UXR08_10400)	-	2074894..2075307 (-)	414	WP_001557448.1	hypothetical protein	-
UXR08_RS10405 (UXR08_10405)	-	2075336..2075446 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=993626 UXR08_RS10375 WP_001017131.1 2069829..2070872(-) (vraS) [Staphylococcus aureus strain BSN57]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=993626 UXR08_RS10375 WP_001017131.1 2069829..2070872(-) (vraS) [Staphylococcus aureus strain BSN57]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1