Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexA   Type   Machinery gene
Locus tag   HMPREF9319_RS09570 Genome accession   NZ_GL397128
Coordinates   1992025..1994595 (-) Length   856 a.a.
NCBI ID   WP_003066925.1    Uniprot ID   E0PGF8
Organism   Streptococcus equinus ATCC 700338     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1987025..1999595
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF9319_RS11285 (HMPREF9319_1997) - 1987367..1987576 (-) 210 WP_003066908.1 hypothetical protein -
  HMPREF9319_RS11290 (HMPREF9319_1998) - 1987534..1987815 (-) 282 WP_003066911.1 hypothetical protein -
  HMPREF9319_RS11295 (HMPREF9319_1999) - 1987885..1988055 (-) 171 WP_231729898.1 hypothetical protein -
  HMPREF9319_RS11300 (HMPREF9319_2000) - 1988116..1988292 (-) 177 WP_003066916.1 hypothetical protein -
  HMPREF9319_RS09555 (HMPREF9319_2001) - 1988440..1989291 (+) 852 WP_003066919.1 helix-turn-helix domain-containing protein -
  HMPREF9319_RS09560 (HMPREF9319_2002) ruvA 1989371..1989964 (-) 594 WP_003066922.1 Holliday junction branch migration protein RuvA Machinery gene
  HMPREF9319_RS09565 (HMPREF9319_2003) hexB 1989966..1991909 (-) 1944 WP_003066924.1 DNA mismatch repair endonuclease MutL Machinery gene
  HMPREF9319_RS09570 (HMPREF9319_2004) hexA 1992025..1994595 (-) 2571 WP_003066925.1 DNA mismatch repair protein MutS Machinery gene
  HMPREF9319_RS09575 (HMPREF9319_2005) - 1994582..1994938 (-) 357 WP_003066927.1 YlbF family regulator -
  HMPREF9319_RS09580 (HMPREF9319_2006) argR 1994935..1995372 (-) 438 WP_003066930.1 arginine repressor -
  HMPREF9319_RS09585 (HMPREF9319_2007) argS 1995562..1997253 (+) 1692 WP_003066932.1 arginine--tRNA ligase -
  HMPREF9319_RS09590 (HMPREF9319_2008) - 1997365..1997658 (+) 294 WP_003066934.1 bacteriocin immunity protein -
  HMPREF9319_RS09595 (HMPREF9319_2009) - 1997700..1999205 (-) 1506 WP_003066936.1 prolyl oligopeptidase family serine peptidase -

Sequence

Protein


Download         Length: 856 a.a.        Molecular weight: 96094.54 Da        Isoelectric Point: 4.8579

>NTDB_id=989454 HMPREF9319_RS09570 WP_003066925.1 1992025..1994595(-) (hexA) [Streptococcus equinus ATCC 700338]
MTKDKISPGMQQYLDVKKDYPDAFLLFRMGDFYELFYDDAVKAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTAVDSSKPDNANNFLVAIDSDGKTFGLAYMDVSTGEFFSTSLSDFTS
LRSEILNLKAREIVVGYELSETEQHSLVKQLNLLLSFEQERYEDVHLIDPDLTALEISAAEKLLQYVHTTQKRELSHLQK
LVHYEIKDYLQMSYTTKSSLDLLENARTSKKHGSLYWLLDETKTAMGMRLLRNWIDRPLVNQAQIEERQNIVQVFLDNFF
ERSDLTDSLKGVYDIERLASRVSFGKANPKDLLQLGHTLAQVPRIKAILESFESPHLDKLVNSIDTLPELESLIRSAIDP
DAPAVITEGSIIRTGFDEILDKYRKVMREGTSWIAEVETKERAASGITNLKIDYNKKDGYYFHVTNSNLSLVPDYFFRKA
TLKNSERFGTAELAKIEGEMLEAREQSASLEYDIFMRVRGQVERYITRLQDLAKALSTVDVLQSLAVVAENNHYVRPTFN
DSHEIKIEKGRHAVVEKVMGTQEYIPNTITFDADINIQLITGPNMSGKSTYMRQLALTVIMAQMGSYVAAESVNLPVFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASSQSLILFDELGRGTATYDGMALAQSIIEYIHDHIGAKTMFATHYHEL
TALSTILTHLVNVHVATLEKNGDVTFLHKIAEGPADKSYGVHVAKIAGLPEELLQRADSILTNLESGAAQLQLTPEVEAE
PITIKSEVAEPVAEQLSLFADDSSNQEVIKVLKKVDLMNLTPMQAMNVIYELKNML

Nucleotide


Download         Length: 2571 bp        

>NTDB_id=989454 HMPREF9319_RS09570 WP_003066925.1 1992025..1994595(-) (hexA) [Streptococcus equinus ATCC 700338]
ATGACAAAAGATAAAATTTCTCCAGGCATGCAACAGTATTTGGACGTAAAAAAAGATTATCCAGATGCTTTTTTACTTTT
CCGCATGGGAGACTTTTATGAATTATTTTATGATGATGCGGTTAAAGCTGCACAGATTTTAGAGATTAGTTTAACTAGTC
GTAATAAAAATGCTGACAACCCAATTCCAATGGCAGGTGTGCCTTATCATTCTGCGCAACAATACATTGATGTATTAGTG
GAAATGGGTTACAAGGTGGCAATTGCTGAGCAAATGGAAGACCCAAAACAAGCCGTCGGTGTGGTTAAACGTGAAGTCGT
TCAAGTGATTACGCCAGGGACAGCTGTTGATTCCTCTAAACCAGATAATGCTAACAATTTCTTGGTGGCTATTGATTCTG
ACGGCAAAACGTTTGGGCTAGCCTATATGGATGTGTCAACAGGTGAATTTTTCTCAACAAGTCTTTCTGATTTTACAAGC
CTTAGAAGTGAAATTCTGAACCTTAAAGCGCGTGAAATCGTTGTTGGTTATGAGCTTTCTGAAACAGAGCAACATAGCTT
AGTCAAACAATTAAATTTACTCTTATCGTTTGAACAAGAACGTTATGAAGATGTGCATTTAATCGACCCAGATTTAACAG
CCTTAGAAATTTCAGCAGCTGAAAAATTGCTACAATACGTTCATACAACGCAAAAACGTGAGCTAAGCCATTTGCAAAAA
TTGGTTCATTATGAAATCAAAGATTACTTGCAAATGTCTTACACGACAAAATCTAGTTTGGATTTATTAGAAAATGCTCG
AACAAGTAAAAAACATGGTAGCCTTTATTGGTTACTAGATGAAACTAAAACGGCTATGGGAATGCGTCTGTTGCGTAATT
GGATTGACCGTCCTTTGGTGAACCAAGCACAGATTGAAGAGCGCCAAAATATTGTTCAAGTTTTCCTAGATAATTTCTTT
GAGCGTAGTGATTTGACGGATAGTCTCAAAGGTGTTTATGATATTGAACGTCTAGCGAGTCGTGTGTCATTTGGAAAAGC
TAATCCAAAAGATTTATTACAACTCGGTCATACCTTGGCACAAGTGCCAAGGATTAAGGCGATTTTAGAATCGTTTGAAA
GCCCTCACCTTGACAAGCTTGTCAATAGCATTGACACTTTGCCAGAACTAGAATCGTTGATTCGATCAGCTATTGACCCA
GATGCTCCTGCTGTTATCACAGAAGGCAGCATTATCCGTACAGGTTTTGATGAGATTTTGGATAAATACCGTAAGGTTAT
GCGCGAGGGGACTAGTTGGATTGCAGAAGTTGAAACTAAGGAACGTGCTGCAAGTGGGATTACCAATCTAAAAATTGATT
ATAATAAAAAAGATGGATACTATTTCCATGTAACAAATTCCAATCTCTCTCTAGTGCCAGATTATTTCTTCCGCAAGGCA
ACGTTGAAAAATTCAGAGCGTTTCGGAACGGCAGAATTGGCTAAAATTGAAGGTGAGATGTTGGAGGCGCGTGAGCAATC
AGCAAGCTTAGAATATGATATTTTTATGCGCGTTCGCGGACAAGTTGAGCGTTACATTACTCGTTTGCAAGACTTGGCTA
AGGCGCTTTCAACCGTTGATGTTTTACAAAGTTTAGCCGTTGTTGCAGAAAATAATCATTATGTTCGTCCAACATTCAAC
GATAGCCATGAGATTAAAATTGAAAAAGGTCGTCATGCGGTCGTTGAAAAAGTCATGGGAACGCAAGAATATATTCCTAA
TACGATTACGTTTGATGCCGATATCAACATTCAGCTAATTACTGGTCCAAATATGAGTGGTAAATCAACTTATATGCGTC
AACTTGCCTTGACCGTTATTATGGCTCAAATGGGGTCTTACGTAGCTGCTGAAAGTGTCAATTTACCAGTATTTGATGCG
ATTTTCACGCGTATTGGTGCGGCAGATGATTTGATTTCAGGACAGTCAACGTTTATGGTGGAAATGATGGAAGCTAACCA
AGCTATCAAACGTGCAAGTTCTCAATCCTTGATTCTTTTTGATGAGCTAGGTCGTGGTACAGCAACCTATGACGGTATGG
CTTTGGCGCAATCAATCATTGAATATATCCATGATCATATTGGTGCAAAGACCATGTTTGCAACCCATTATCATGAGTTG
ACAGCTTTGTCAACGATCTTGACGCATCTTGTCAATGTTCACGTTGCGACTCTTGAGAAAAATGGTGATGTGACTTTTCT
TCATAAAATTGCAGAAGGTCCAGCAGACAAATCTTACGGGGTTCATGTTGCAAAAATTGCTGGTTTACCAGAAGAATTAT
TACAACGTGCGGACAGTATCTTGACAAATTTAGAATCAGGTGCTGCGCAGCTTCAATTGACCCCTGAGGTGGAAGCTGAG
CCAATTACTATAAAATCAGAAGTAGCAGAACCAGTGGCAGAGCAACTAAGTTTATTTGCTGATGACTCATCTAATCAAGA
AGTGATTAAAGTACTCAAAAAAGTTGATTTGATGAATTTAACACCAATGCAAGCCATGAATGTTATTTATGAATTAAAAA
ATATGTTGTAA

Domains

Predicted by InterProScan.

MutS domain I (MutS_I)

(8-118)

MutS domain II (MutS_II)

(126-239)

MutS family domain IV (MutS_IV)

(415-505)

MutS domain III (MutS_III)

(256-546)

MutS domain V (MutS_V)

(599-785)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB E0PGF8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexA Streptococcus pneumoniae R6

71.729

100

0.717
  mutS Pseudomonas stutzeri strain ATCC 17587

37.586

100

0.382