Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   R8635_RS07415 Genome accession   NZ_AP026924
Coordinates   1428462..1429796 (-) Length   444 a.a.
NCBI ID   WP_000491790.1    Uniprot ID   Q7B3G0
Organism   Streptococcus pneumoniae strain PZ900700063     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1423462..1434796
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8635_RS07400 (PC0062_14720) - 1424422..1426872 (-) 2451 WP_268217846.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -
  R8635_RS07405 (PC0062_14730) - 1427072..1428001 (-) 930 WP_000411857.1 peptidase U32 family protein -
  R8635_RS07410 (PC0062_14740) - 1428141..1428428 (+) 288 WP_001145225.1 DUF3270 domain-containing protein -
  R8635_RS07415 (PC0062_14750) ciaH 1428462..1429796 (-) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  R8635_RS07420 (PC0062_14760) ciaR 1429786..1430460 (-) 675 WP_000590640.1 two-component system response regulator CiaR Regulator
  R8635_RS07425 (PC0062_14770) - 1430569..1433115 (-) 2547 WP_001864895.1 M1 family metallopeptidase -
  R8635_RS07430 (PC0062_14780) - 1433237..1433677 (-) 441 WP_000188806.1 ASCH domain-containing protein -
  R8635_RS07435 (PC0062_14790) - 1433689..1433886 (-) 198 WP_050199109.1 hypothetical protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50673.39 Da        Isoelectric Point: 9.1661

>NTDB_id=98268 R8635_RS07415 WP_000491790.1 1428462..1429796(-) (ciaH) [Streptococcus pneumoniae strain PZ900700063]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=98268 R8635_RS07415 WP_000491790.1 1428462..1429796(-) (ciaH) [Streptococcus pneumoniae strain PZ900700063]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTTATTCTCTTTGATAAGGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAGGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCTTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q7B3G0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

100

100

1
  ciaH Streptococcus pneumoniae D39

100

100

1
  ciaH Streptococcus pneumoniae R6

100

100

1
  ciaH Streptococcus pneumoniae TIGR4

100

100

1
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment