Detailed information NTG0095562

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: QMM33_RS10570
• Genome accession: NZ_AP025940
• Coordinates: 486154..486741 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PZ900700204
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 481154..491741

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QMM33_RS02480 (PC0204_04740)	-	481618..482958 (+)	1341	WP_050212001.1	sensor histidine kinase	-
QMM33_RS02485 (PC0204_04750)	blpC	483000..483155 (-)	156	WP_044791640.1	quorum-sensing system pheromone BlpC	-
QMM33_RS02490	-	483212..484573 (-)	1362	Protein_492	bacteriocin secretion accessory protein	-
QMM33_RS02495 (PC0204_04780)	comA/nlmT	484584..486260 (-)	1677	WP_318155894.1	peptide cleavage/export ABC transporter	Regulator
QMM33_RS10570 (PC0204_04790)	comA/nlmT	486154..486741 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
QMM33_RS02500 (PC0204_04800)	blpM	487023..487277 (+)	255	WP_001093256.1	two-peptide bacteriocin subunit BlpM	-
QMM33_RS02505 (PC0204_04810)	blpN	487293..487496 (+)	204	WP_001099490.1	two-peptide bacteriocin subunit BlpN	-
QMM33_RS02510 (PC0204_04820)	cipB	487740..487889 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
QMM33_RS02515	-	487993..488112 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
QMM33_RS02520 (PC0204_04830)	-	488410..488574 (+)	165	WP_000727117.1	hypothetical protein	-
QMM33_RS02525 (PC0204_04840)	-	488636..488974 (+)	339	WP_088804618.1	immunity protein	-
QMM33_RS02530 (PC0204_04860)	-	489603..489986 (+)	384	WP_000877381.1	hypothetical protein	-
QMM33_RS02535 (PC0204_04870)	-	490038..490727 (+)	690	WP_000760520.1	CPBP family intramembrane glutamic endopeptidase	-
QMM33_RS02540 (PC0204_04880)	blpZ	490769..491017 (+)	249	WP_000276501.1	immunity protein BlpZ	-
QMM33_RS02545	-	491047..491658 (+)	612	WP_000394036.1	type II CAAX endopeptidase family protein	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=95562 QMM33_RS10570 WP_000205166.1 486154..486741(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700204]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=95562 QMM33_RS10570 WP_000205166.1 486154..486741(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700204]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTT
CTTATTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497