Detailed information NTG0945769

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ACF0HW_RS18895
• Genome accession: NZ_CP171208
• Coordinates: 3787998..3789194 (+)
• Length: 398 a.a.
• NCBI ID: WP_012118892.1
• Uniprot ID: A7ZAN8
• Organism: Bacillus amyloliquefaciens strain HN11
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 3782998..3794194

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACF0HW_RS18875	walK	3783093..3784928 (+)	1836	WP_004393106.1	cell wall metabolism sensor histidine kinase WalK	-
ACF0HW_RS18880	yycH	3784918..3786276 (+)	1359	WP_004393107.1	two-component system activity regulator YycH	-
ACF0HW_RS18885	-	3786263..3787102 (+)	840	WP_012118893.1	two-component system regulatory protein YycI	-
ACF0HW_RS18890	vicX	3787117..3787911 (+)	795	WP_007407895.1	MBL fold metallo-hydrolase	Regulator
ACF0HW_RS18895	htrA	3787998..3789194 (+)	1197	WP_012118892.1	S1C family serine protease	Regulator
ACF0HW_RS18900	-	3789706..3789915 (+)	210	WP_012118891.1	winged helix-turn-helix domain-containing protein	-
ACF0HW_RS18905	-	3789912..3791330 (+)	1419	WP_012118890.1	cell wall metabolism sensor histidine kinase WalK	-
ACF0HW_RS18910	-	3791562..3792569 (+)	1008	WP_023357221.1	ThiF family adenylyltransferase	-
ACF0HW_RS18915	-	3792566..3793888 (+)	1323	WP_012118888.1	ABC transporter substrate-binding protein	-

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 42591.36 Da
• Isoelectric Point: 6.9987

>NTDB_id=945769 ACF0HW_RS18895 WP_012118892.1 3787998..3789194(+) (htrA) [Bacillus amyloliquefaciens strain HN11]
MDYNRDDEQYASEQPRRSKRGYFLSSLIGVIVGAALMAFLLPYWTGGDHGENSKSTSQRLGSEQVKTVNVNVNDAVTNMV
SRVSDSVVGVLNIQKTDIWGEGGEAGSGSGVIYKKNGNTSYIVTNHHVIEGATEIEISLKDGSRVPAELIGSDSLMDLAV
LKVKSDKIKSAAQFGNSDQVKVGEPVIAIGNPLGLEFAGSVTQGIISGTERAVPVDSNGDGQPDWNAEVLQTDAAINPGN
SGGALMDISGKVVGINSMKIAESAVEGIGLSIPSKLVIPVIQDLEKYGEVRRPFLGIEMKSLTDIASYHWSQTLKLPKGV
KTGAVIMGVDAFSPAGKAGLKKLDVITGFDGHKVNDVVDLRERLYRKKIGDRVNITFYRSGKKKTAEVKLTEADRLQK

Nucleotide

• Length: 1197 bp

>NTDB_id=945769 ACF0HW_RS18895 WP_012118892.1 3787998..3789194(+) (htrA) [Bacillus amyloliquefaciens strain HN11]
GTGGATTATAATCGCGATGATGAACAGTACGCCTCCGAACAGCCCCGCCGCAGCAAGAGAGGGTACTTTCTATCAAGTCT
GATCGGCGTCATCGTCGGGGCCGCGCTCATGGCTTTCCTGCTGCCGTACTGGACAGGCGGAGATCATGGAGAAAACAGCA
AAAGCACCAGCCAGCGTCTCGGCAGCGAACAGGTGAAAACAGTCAACGTAAATGTCAATGACGCTGTCACGAATATGGTC
AGCCGTGTATCAGATTCGGTAGTCGGCGTTCTCAATATCCAAAAGACCGATATTTGGGGAGAGGGCGGCGAAGCGGGAAG
CGGGTCGGGCGTCATTTACAAAAAGAACGGAAACACTTCTTATATCGTAACCAATCACCATGTCATTGAAGGTGCGACTG
AGATTGAGATCAGCCTGAAGGATGGCTCACGCGTGCCTGCTGAGCTGATCGGGAGCGACAGTCTGATGGATCTCGCTGTG
CTGAAGGTGAAATCTGATAAAATCAAATCGGCCGCCCAGTTCGGCAATTCCGATCAGGTCAAAGTCGGAGAACCGGTCAT
TGCGATCGGAAATCCGCTTGGGCTTGAATTTGCGGGATCAGTGACACAGGGGATCATTTCAGGCACGGAAAGGGCGGTGC
CCGTTGACTCAAACGGCGACGGACAGCCGGATTGGAATGCGGAAGTGCTGCAGACCGATGCCGCGATTAACCCCGGCAAC
AGCGGCGGCGCTTTGATGGATATATCGGGCAAGGTGGTCGGCATCAACTCAATGAAGATCGCTGAATCCGCCGTTGAAGG
GATCGGCCTGTCCATCCCGTCAAAGCTTGTCATTCCCGTTATTCAGGATTTAGAAAAATACGGAGAAGTCAGACGGCCTT
TCCTCGGTATTGAGATGAAATCCTTAACGGATATTGCGAGCTACCATTGGAGCCAGACGCTGAAACTTCCGAAAGGCGTT
AAAACCGGGGCGGTCATTATGGGTGTCGACGCGTTTTCACCGGCCGGAAAAGCGGGTTTGAAAAAGCTTGACGTAATCAC
CGGGTTCGACGGACATAAGGTCAATGACGTTGTGGATCTCCGTGAGCGCCTGTATCGCAAAAAGATCGGTGACCGTGTGA
ACATCACGTTCTACCGTTCGGGAAAGAAAAAAACAGCGGAAGTCAAACTGACAGAAGCGGATCGATTACAGAAATAA

Domains

Predicted by InterProScan.

• Peptidase family M50 (Peptidase_M50) (265-394)

• PDZ domain (PDZ_2) (293-390)

• Trypsin-like peptidase domain (Trypsin_2) (108-255)

3D structure

• AlphaFold DB: A7ZAN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	43.939	99.497	0.437
htrA	Streptococcus gordonii str. Challis substr. CH1	40.052	97.236	0.389
htrA	Streptococcus mitis NCTC 12261	43.636	82.915	0.362