Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ACB356_RS06240 Genome accession   NZ_CP166998
Coordinates   1251200..1251841 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain Isolate 35     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1246200..1256841
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB356_RS06215 (ACB356_06215) comFA/cflA 1246287..1247612 (-) 1326 WP_002988971.1 DEAD/DEAH box helicase Machinery gene
  ACB356_RS06220 (ACB356_06220) - 1247667..1248299 (+) 633 WP_002988970.1 YigZ family protein -
  ACB356_RS06225 (ACB356_06225) cysK 1248427..1249368 (+) 942 WP_002988967.1 cysteine synthase A -
  ACB356_RS06230 (ACB356_06230) - 1249386..1249763 (-) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  ACB356_RS06235 (ACB356_06235) - 1249763..1251163 (-) 1401 WP_002983672.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ACB356_RS06240 (ACB356_06240) vraR 1251200..1251841 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  ACB356_RS06245 (ACB356_06245) - 1251834..1252838 (-) 1005 WP_002983669.1 sensor histidine kinase -
  ACB356_RS06250 (ACB356_06250) liaF 1252835..1253527 (-) 693 WP_002988964.1 cell wall-active antibiotics response protein LiaF -
  ACB356_RS06255 (ACB356_06255) pknB 1253650..1255548 (-) 1899 WP_002988962.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ACB356_RS06260 (ACB356_06260) - 1255545..1256285 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=929414 ACB356_RS06240 WP_002983671.1 1251200..1251841(-) (vraR) [Streptococcus pyogenes strain Isolate 35]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=929414 ACB356_RS06240 WP_002983671.1 1251200..1251841(-) (vraR) [Streptococcus pyogenes strain Isolate 35]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCCTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAGGTGGACAAAA
AAATTAAAGCGCATGACCAACACCCTGATTTGCATGAAGAGCTAACCGCGCGCGAGTATGATATTTTACATCTTTTAGCT
AAAGGGTATGATAATCAAACTATAGCGGATGAACTTTTCATCTCCTTGAAAACCGTTAAAACGCATGTATCTAATATTCT
TGCTAAGCTAGAAGTTGATGACCGAACTCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385